European Psychiatry - Volume 41 - April 2017

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S376 25th European congress of psychiatry / European Psychiatry 41S (2017) S365–S404
3 Tehran University, Psychology, Tehran, Iran
∗ Corresponding author.
Objectives The purpose of this study was investigating the effec-
tiveness of rTMS (repetitive transcranial of magnetic stimulation)
on increase social performance in patients with recurrent major
depression.
Method It was used a quasi-experimental, pretest–posttest
design with control group, a sample consisting of 32 patients who
had depression on the basis of DSM-IV diagnostic criteria, SCID and
BDI-II scales and were randomly assigned to two groups.
The experimental group underwent 20 sessions of rTMS as the
independent factor and both groups (control & experimental) had
12-session psychotherapy and drugs treatment. Upon the inter-
vention, both groups were tested with two tests (BDI-II & SASS). To
determine the effect of the independent factor on the dependent
factor of rTMS.
Data were analyzed by t-test.
Results The comparison between pre- & posttest of all the tests
showed the reduction of signs & symptoms of depression, (a = 0/05)
(Beck scale P ≤ 0/001 & F = 30) and increase social performance in
participants (P ≤ 0/001 & F = 83).
Conclusion The rTMS is effect in the reduction of signs & symp-
toms of depression and increase social functioning in recurrent
major depression.
Keywords Social performance; Magnetic stimulation; Major
depression
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0783
The research of electroconvulsive
therapy effect on cognitive function in
rats with depressive-like disorder
formed by ultrasound
V. Ushakova ∗, E. Zubkov , A. Morozova , A. Gorlova ,
D. Pavlov , A. Inozemtsev , V. Chekhonin
1 Lomonosov Moscow State University, Department of Biology,
Moscow, Russia
2 Serbsky State Federal Medical Research Centre for Psychiatry and
Narcology, Department of Fundamental and Applied Neurobiology,
Moscow, Russia
∗ Corresponding author.
Electroconvulsive therapy (ECT) is effective method of resistant
depression treatment. ECT activates neurotransmitter systems,
increases neurotrophic factors production, induces neurogenesis.
Nevertheless, ECT side effects, expressed as temporary amnesia,
limit its application in clinical practice.
The objective of our work was to estimate rat’s memory after ECT
in the behavioral test: “Object recognition”, “Morris water-maze”.
The aim of the work was to research the effect of ECT on cognitive
function in rats with depressive-like disorder and in normal rats.
Methods The research was conducted with Sprague-Dawley rats
(n = 41, 2 month age). Experimental stages:
– control group (n = 10) compared to control + ECT group ([70mA,
50Hz, 500 sec; 10 days] n = 10);
– control group (n = 9) compared to group with depressive-like dis-
order, formed by ultrasound ([20–45 kHz; 21days] US, n = 6) and
group with depressive-like disorder received ECT (n = 6).
Memory was estimated in the “Object recognition” and “Morris
water-maze” tests.
Results (1) ECT did not decrease cognitive function in the “Object
recognition” test in normal rats (P = 0.1217). Also, it did not lead
to cognitive impairments in the “Morris water-maze” test: time
of platform searching did not differ significantly from the control
group (P = 0.8573).
(2) ECT produced recovering effect on memory impairments of the
US group in the “Object recognition” test ( P = 0.0066). In the “Mor-
ris water-maze” ECT decreased time of platform searching by 7
times compared to the US group ( P= 0.0025). That demonstrates
the absence of ECT negative effect on rat’s memory.
Conclusion ECT does not produce negative effect on cognitive
function in rats with depressive-like disorder and even recovers
memory impairments.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0784
Glucocorticoid activeness in patients
with mitral valve prolapse and
autonomic dysfunction
E. Pervichko ∗, A. Martynov , Y. Zinchenko
1 Lomonosov Moscow State University, Faculty of Psychology,
Moscow, Russia
2 Moscow State University of Medicine and Dentistry, Faculty of
General Medicine, Moscow, Russia
∗ Corresponding author.
Background Urgency of psychophysiological examination of
mitral valve prolapse (MVP) patients is suggested by a high inci-
dence of anxiety disorders among these patients.
Objectives To study glucocorticoid function activity and emo-
tional stress resistance in MVP patients with autonomic dysfunc-
tion (AD).
Methods The trait anxiety level (TA) was assessed with the
State-Trait Anxiety Inventory (Spielberger). Emotional stress resis-
tance was undertaken with our modified version of Rosenzweig
Picture-Frustration Test (Zinchenko, Pervichko). The cortisol level
in blood plasma was measured by radioimmunoassay technique
with radioimmune assay kit of cortisol in human blood plasma
‘KORT-3N’ (Belarus). There were 32 MVP patients (mean age was
28.5 ±1.6 years) and 15 healthy people (mean age was 27.5 ± 1.3
years) who took part in the study.
Results Among reactions to frustration revealed by MVP patients
the following categories are dominating: extrapunitive (E), ego-
defensive (ED), and obstacle-dominance (OD). Therewas revealed a
direct correlations: TA and E ( r= 0.49, Р < 0.001); TA and ED ( r= 0.46,
Р < 0.01); TA and indexes of AD (r = 0.43, Р < 0.01).
There was displayed a higher level of cortisol in MVP patients with
severe grade of AD, against the level revealed by patients with
average grade of AD (433.9 ±78.0mmol/L vs. 299.3 ±42.9mmol/L;
Р < 0.05). Direct correlations were established between the cor-
tisol level and the level of TA (r = 0.45; Р < 0.01); between the
frequency of E-reactions in Modified Rosenzweig Test and cortisol
level (r = 0.42; Р < 0.01).
Conclusion Along with low stress resistance, registered AD and
high level of TA, MVP patients reveal higher indexes of cortisol in
blood plasma.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0785
Life events, quality of life, autonomic
nervous system, and cardiovascular
risk factors
M. Slepecky ∗, I. Majercak , E. Gyorgyova , A. Kotianova ,
M. Kotian , M. Zatkova , M. Chupacova , M. Popelkova ,
M. Ociskova , J. Prasko , I. Gallová
1 UKF Nitra, Psychology, Liptovsky Mikulas, Slovak Republic
2 Pavol Jozef Safarik University, Department of Internal Medicine,
Kosice, Slovak Republic