European Psychiatry - Volume 41 - April 2017

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25th European Congress of Psychiatry / European Psychiatry 41S (2017) S465–S520 S489
Treponema pallidum serology, and he was diagnosed with neu-
rosyphilis. He was treated with a single dose of intramuscular
penicillin, but experienced marked deterioration of neurological
symptoms (paraparesis and truncal ataxia) and was transferred to
the general hospital for an extended 14 day course of intravenous
penicillin. Following this extended course of antibiotic therapy,
resolution of neurological symptoms was seen, but no sustained
improvement in residual psychotic symptoms has been seen.
Conclusions This case demonstrates the potential neuropsychi-
atric consequences of neurosyphilis, and serves as a reminder of
its potential to imitate other psychiatric presentations. This gen-
tleman, and many like him, continue to experience severe and
enduring psychopathology despite penicillin treatment when cases
are detected late. Given the potential consequences of this, we
would advocate assertive screening for syphilis in patients admit-
ted to psychiatric units.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV0261
Liaison psychiatry–characterization of
inpatients with psychiatric pathology
in the infectiology service
T. Carvalhao
Hospitais da universidade de Coimbra, psychiatry, Coimbra, Portugal
Introduction The interface of the Liaison Psychiatry with Infecti-
ology is fundamental for the continuous and specialized support of
these patients. Prevalent psychiatric records are known in the HIV
infection, such as anxiety, depression and abuse and/or addiction
to substances. There are also different neuropsychiatric situations
associated with this infection owing, namely, to the HIV direct
action on the central nervous system, to the adverse effect of
the antiretroviral therapy and to the resurgence of existing prior
pathology.
Objective The author intends to characterize the population eval-
uated in the Liaison psychiatry in the Coimbra university hospital
with respect to inpatients of the Infectiology Service in a central
hospital in order to optimize resources and better adjust interven-
tions made.
Methods and results The quantitative retrospective study was
carried out betweenMay 2015 andMay 2016, with a duration of one
year, in the infectiology service of the Coimbra university hospital.
Observation and evaluation of the inpatient of the infectiology
service having in view the sample characterization in relation to
demographic data, nature of the request, antiretroviral therapy,
psychiatric diagnosis, type of intervention and follow-up. The quan-
titative data were subject to statistical analysis.
Conclusion The prevalence of the psychiatric disorders associ-
ated with HIV infection is high and with great emotional impact
and implications in the personal, sexual, occupational and social
life of the individual. The diagnosis and treatment of the psychi-
atric comorbidity is determinant in the patients’ evolution, both in
reducing suffering associated with experience of HIV infection and
in its implications.
Disclosure of interest The author has not supplied his/her decla-
ration of competing interest.
EV0262
From ‘Big 4 to ‘Big 5 : A review and
epidemiological study on the
relationship between psychiatric
disorders and World Health
Organization preventable diseases
G. Chartier Cawthorpe ∗
1 The university of British columbia, psychiatry, Vancouver, Canada
2 University of Calgary, psychiatry, Calgary, Canada
∗ Corresponding author.
Introduction Chronic diseases, such as heart disease, stroke,
chronic respiratory diseases and diabetes, are by far the leading
causes of mortality in the world, representing 60% of all deaths.
However, chronic disease rarely exists in isolation. Nevertheless,
study of chronic disease rarely takes into account comorbidity and
virtually none examine their occurrence in populations.
Objectives and aims To review the association between psychi-
atric disorders and other medical comorbidities.
To study the association between psychiatric diseases and medical
comorbidities on a population-scale.
To reconsider our approach to medical comorbidities.
Methods Using an informatics approach, a dataset containing
physician billing data for 764 731 (46% male) individuals span-
ning sixteen fiscal years (1994–2009) in Calgary, Alberta, Canada
was compiled permitting examination of the relationship between
Physical Disorders andMental Disorders, based on the International
Classification of Diseases (ICD).
Results All major classes of ICD physical disorders had odd ratios
with confidence intervals above the value of 1.0. Ranging from 1.47
(Injury poisoning) to Circulatory systems (3.82). More precisely,
when a psychiatric disorder is present, the likelihood todevelopone
of the four preventable diseases is significantly increased: Stroke
(4.27), Hypertension (3.34), Diabetes (2.66) and COPD (2.43).
Conclusion We postulate that psychiatric disorder should be
included in the classification of preventable chronic diseases that
have a profound impact on society. Developing a consistent and
standardized approach to describe these features of disease has the
potential to dramatically shift the format of both clinical practice
and medical education.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV0263
A rare type primary central nervous
system lymphoma with primarily
psychiatric diagnosis- a case report
U. Cikrikcili ∗, B. Saydam , M. Aktan
1 Istanbul university, psychiatry, Istanbul, Turkey
2 Istanbul university, hematology, Istanbul, Turkey
∗ Corresponding author.
Primary central nervous system lymphoma (PCNSL) is a high-grade
malignant B-cell non-Hodgkin neoplasm that is an infrequent vari-
ant of all intracranial neoplasms (1%) and all lymphomas (< 1%)
PCNSL is documented mainly in immunocompromised patient
groups, although it may also be diagnosed in immunocompetent
patients. It affects mainly the eyes, supratentorial areas, or the
spinal cord. The lesions are typically localized in frontal lobes, cor-
pus callosum and basal ganglia. Additionally, lesions might rarely
be detected at infratentorial areas and in medulla spinalis. Even
though a wide spectrum of treatment options are available, such
as chemotherapy, radiotherapy, or surgery; response rates are low
and prognosis is poor in spite of appropriate treatment.
The case we reported here is 57-year-old male presented with
symptoms of aggresivity, impulsivity, depressive mood and per-
sonality changes. Histopathological diagnosis was CD5 positive
diffuse large B cell lymphoma, which is very rare in high-grade lym-
phomas. Therewere no neurological signs related to CNS tumor and
the clinical manifestations responded very well to chemotherapy
consisting of high dose methotrexate, vincristine and procar-
bazine. The significance of such neuropsychiatric symptoms in the
course of treatment for PCNSL has been previously documented as
well. These behavioral and emotional symptoms might manifest