European Psychiatry - Volume 41 - April 2017

538 / 916

S534 25th European Congress of Psychiatry / European Psychiatry 41S (2017) S521–S582
EV0398
Correlations between doctors’ and
patients’ assessment of depression’
severity and efficacy of treatment
V. Medvedev ∗, K. Retyunsky , A. Ovchinnikov , Y. Barilynik ,
A. Shmilovich , E. Antohin , G. Usov , V. Frolova
1 PFUR University, Chair of Psychiatry, Psychotherapy and
Psychosomatic Pathology, Moscow, Russia
2 Ural State Medical University, Chair of Psychiatry, Ekaterinburg,
Russia
3 Novosibirsk State Medical University, Chair of Psychiatry, Narcology
and Psychotherapy, Novosibirsk, Russia
4 Saratov State Medical University, Chair of Psychiatry, Narcology,
Psychotherapy and Medical Psychology, Saratov, Russia
5 Russian Medical Research Medical University, Chair of Psychiatry
and Medical Psychology, Moscow, Russia
6 Orenburg State Medical University, Chair of Clinical Psychology and
Psychotherapy, Orenburg, Russia
7 Omsk State Medical Academy, Chair of Psychiatry, Narcology,
Psychotherapy and Clinical Psychology, Omsk, Russia
∗ Corresponding author.
Introduction Data on accordance and clinical significancy of
objective (doctor, psychometric scales) and subjective (patientwith
depression) assessment of severity of depression are almost lack-
ing. Aim of the multicenter study “EMOTION” was to compare
prognostic value of doctor’s and patient’s assessment of depressive
symptoms severity as for its grading and treatment outcome.
Method Study sample consist of 107 depressive patients. The
study used clinical and psychometric (HDRS, SHAPS, CGI-S, CGI-I,
PGI-S, PGI-I, Visual Analog Scale) methods.
Results Our data suggest that there’s statistically significant
(Р < 0.001) discrepancy between doctors’ (CGI-S) and patients’
(PGI-S) assessment of depressive symptoms’ severity at first visit.
Concordant opinions were found only in “marked depression”
(37.49% of doctors and 36.59% of patients) and in “borderline
depression” (4.79% of doctors and 3.79% of patients). Otherwise,
doctors’ and patients’ opinions were discordant. Doctors’ scores
were more extreme (severe and extremely severe depression);
patients’ scores were more “moderate”. We have found inconsis-
tence between HDRS and CGI-S scores. In the course of reduction
of depression severity during antidepressive treatment (agomela-
tine) doctors’ and patients’ scores were more and more in line with
each other.
Conclusion We have found leveling of prognostic value of psycho-
metric assessment of depression severity by doctors and patients
(in terms of reduction of depressive symptoms severity and treat-
ment outcome) during antidepressive therapy. It is possible that in
some HDRS items scores were overestimated.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV0399
Comorbid depression and ulcerative
colitis – is there a connection?
A. Melada ∗, I. Kriˇsto-Ma –dura , A. Vidovi´c
CH Dubrava, Department of Psychiatry, Zagreb, Croatia
∗ Corresponding author.
Ulcerative colitis (UC) is a subset disorder of inflammatory bowel
disease (IBD) with chronic course and symptoms such as fatigue,
gastrointestinal pain, fever, etc. IBD is associated with psycho-
logical manifestations including depression and anxiety. There
is an increased number of studies trying to link these comor-
bidities. The gut-brain axis is regulated by intestinal microbiota
and this bidirectional communication including immune, neu-
ral, endocrine and metabolic mechanisms may bring us closer to
the answer. The following case concerns a 56-year-old patient
with history of major depressive disorder who was in contin-
uous psychiatric care and treated with antidepressants. Several
years after the beginning of psychiatric treatment, he was hospi-
talized for diagnostic examination due to subfebrility of unknown
etiology, but with no final somatic diagnosis. After two years he
was referred to our department and at administration the patient
showed symptoms of depression, anxiety, lack of motivation and
suicidal thoughts and tendencies. Subfebrility was still present
at that time. His psychopharmacotherapy was revised and there
was a slight improvement in mood and behaviour. During outpa-
tient follow-ups the symptoms of depression were still prominent
and remission was not achieved even with modulation of antide-
pressant pharmacotherapy. The following year the patient was
diagnosed with UC and started specific treatment after he pre-
sented with diarrhea in addition to subfebrility. Subsequently his
mood improved, suicidal thoughts were diminished and ultimately
remission was achieved. This case suggests that only after UC
was being treated the psychiatric symptoms also withdrew which
implicates that inflammatory mediators were involved in patho-
genesis of depression.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV0400
C-reactive protein as predictor of
antidepressant response in late onset
depression
D.K. Mishra ∗, U. Sardesai , R. Razdan
1 Resident, Department of Psychiatry, M.G.M., Medical College, Indore
2 Assistant Professor, Department of Psychiatry, M.G.M., Medical
College, Indore
3 Head Department of Psychiatry, M.G.M., Medical College, Indore
∗ Corresponding author.
Introduction Late-onset depression has been associated with
history of vascular disease and atherosclerosis. As immune dysreg-
ulation is critically involved in vascular disease. We hypothesized
that responsiveness of late onset depression can be associated with
level of inflammatory markers in these subjects.
Objective Role of inflammatory mediator in antidepressant
responses in late onset depression.
Aim To study C-reactive protein as predictor of antidepressant
response in late onset depression.
Methods Depressed patient (as per ICD 10 DCR) age > 60 years
recruited from department of psychiatry and complete clinical
assessment done and base line depression severity measure on
Hamilton Depression Rating Scale (HDRS). C reactive protein level
was assessed at base line. Patient prescribed antidepressant medi-
cation and at 8 week follow up re assed for depression severity in
HDRS. Data analyzed with spss.21 and spearman correlation was
used.
Result Mean age of responder (n = 6) 63.5 ± 4.9 year and HDRS at
base line 16 ± 1.9. Mean age of partial responder or non-responder
(n = 19) 65.1 ±6.1 year and HDRS at base line 18.5 ± 3.9. Continuous
decrease in depression severity during study period and antide-
pressant response rate was 24%. Base line CRP level had negative
correlation with antidepressant responsiveness (r= –0.6, P < 0.05).
Discussion Late onset depression was less responsive to antide-
pressant medication and poor antidepressant response rate was
associated with higher level of CRP in late onset depression.
Document not received.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.