European Psychiatry - Volume 41 - April 2017

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S544 25th European Congress of Psychiatry / European Psychiatry 41S (2017) S521–S582
units in Sfax and Tunis, Tunisia. These participants, randomly cho-
sen, were asked to answer a questionnaire after their consent.
Depressive symptoms were evaluated using the “Beck Depression
Inventory” (BDI).
Results The mean age of participants was 39.84 years. Among
them, 38.6% had a loweducational level (illiterate or primary school
level); 45.3% were professionally inactive and 92.9% had a low
to medium socio economic level. Medical, psychiatric and suicide
attempt historieswere reported respectively in51.2%, 7.6% and1.8%
of cases. According to BDI, a mild depression was noted in 22.9%;
moderate 16.1%; severe 4.1%. Among those presenting a moderate
to severe depression (MSD), only 16.8%were followed up in psychi-
atry, 4.2% were receiving antidepressant and 9.8% benzodiazepine.
MSD was associated with low educational level (P < 0.001); low
to medium socio economic level (P< 0.001); psychiatric histories
(P < 0.001); suicide attempt histories (P < 0.001); somatic histories
(P < 0.001).
Conclusion Our study highlighted a high prevalence of depres-
sion that is still under diagnosed and therefore poorly managed.
General practitioners should be made aware of the importance of
screening for depression in medical patients because it not only
complicates their overall medical treatments, but also impedes
their physical and social functioning.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV0430
Depressive symptoms among genders
M. Vnukova ∗, J. Raboch , R. Ptacek , I. Sebalo
1 Department of Psychiatry, First Faculty of Medicine Charles
University in Prague and General University Hospital in Prague,
Department of Psychiatry, Prague, Czech Republic
2 Maastricht University, Faculty of Psychology and Neuroscience,
Forensic Psychology, Psychology and Neuroscience, Maastricht, The
Netherlands
∗ Corresponding author.
Introduction Depression is one of the most well-known psycho-
logical issues and is among the most severe ones. World Health
Organisation’s (WHO) report on health identifies 1.9% lifetime
prevalence of depressive episode for males and almost twice as
high–3.2% for females.
Methods This study aimed to map the depressive symptoms
among working population in Czech Republic.
Results Analysis of covariance showed that there is significant
effect of age F(52) = 6.58, P = 0.010 and gender F(52) = 12.53, P < .001
and t-tests showed the means of BDI II scores were significantly
different for genders with females having higher mean (11.91) than
males (9.80), t(1025) = −3.42, P< .001.
Conclusion The clinical burden of depression is still an increas-
ing one in today’s society and this research helped to identify the
potentially most vulnerable individuals. These seem to be working
women aged 35–44.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV0431
Core self-evaluation and depression
among caregivers of Alzheimer
disease patients
E. Wojtyna ∗, A. Pyszkowska , M. Cembrzy ´nska ,
A. Wiszniewicz
1 University of Silesia, Institute of Psychology, Katowice, Poland
2 Hospicy, Cordis, Katowice, Poland
∗ Corresponding author.
Introduction Caregivers of Alzheimer Disease (AD) patients suffer
from chronic stress and psychophysical burden, which often lead
to depression symptoms. It seems that core self-evaluation (CSE),
coping with stress and social support might be modifying factors
in coping with situation of caregiving.
Aims The aims of the study were to examine: (1) level of depres-
sion; (2) relationships between CSE, style of coping with stress,
social functioning and depression severity among caregivers.
Methods The study involved 60 caregivers of AD patients who
were children of the sick and have been caring for at least one year.
It was cross-sectional and assessed by questionnaires. Following
tools were used: Core Self-Evaluation, Beck Depression Inventory,
Coping Inventory for Stress Situations, Distress Thermometer and
an original questionnaire assessing the situation of caregiving.
Results A total of 51.7% of responders demonstrated severity
of depression symptoms, associated to at least one mild clinical
depression episode. The factors introduced to the model explained
65% variance of depression symptoms. Predictors of greater depres-
sion symptoms proved to be: low CSE ( R2 = 0.32; = −0.12),
low social support ( R 2 = 0.08; = −0.27), low life satisfaction
( R2 = 0.02, = −0.26), high levels of distress ( R2 = 0.12, = 0.31),
coping style focused on emotions ( R2 = 0.12, = 0.17).
Conclusions In the area of caregivers’ psychological assistance
and depression therapy, interventions leading to increase of CSE
and providing adequate social support that contributes to better
care provision and maintaining proper self-image, should be taken
into consideration.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV0432
Neurometabolic alterations in a
depression-like rat model of chronic
forced swimming stress using in vivo
proton magnetic resonance
spectroscopy at 7 T
C.H. Yoo ∗ . Song Lim . Woo . Choe
1 The Catholic University of Korea, Department of Biomedical
Engineering and Research Institute of Biomedical Engineering, Seoul,
Republic of Korea
2 Asan Medical Center, Asan Institute for Life Science, Seoul, Republic
of Korea
∗ Corresponding author.
Although recent investigations of major depressive disorder (MDD)
have focused on the monoaminergic system, accumulating evi-
dence suggests that alternative pathophysiological models of MDD
and treatment options for patients with MDD are needed. Animals
subjected to chronic forced swim stress (CFSS) develop behavioral
despair. The purpose of this study was to investigate the in vivo
effects of CFSS in the rat prefrontal cortex (PFC) with 7 T and short-
echo-time proton magnetic resonance spectroscopy (1H MRS). Ten
male Wistar rats underwent 14 days of CFSS, and in vivo 1H MRS
and forced swim tests were performed before and after CFSS. Point-
resolved spectroscopy was used to quantify metabolite levels in
the rat PFC. The spectral analyses showed that in vivo 1H MRS can
be used to reliably assess the Glu system. The rats showed signifi-
cantly increased immobility times and decreased climbing times in
the FST after CFSS, which suggested that the rats developed behav-
ioral despair. The pre-CFSS and post-CFSS Glu and Gln levels did
not significantly differ (P > 0.050). The levels of myo-inositol, total
choline, and N-acetylaspartate, myo-inositol/creatine, and total
choline/creatine increased significantly (P < 0.050). Similar find-
ings have been reported in patients with MDD. Taken together,
these results suggested that the CFSS-induced metabolic alter-
ations were similar to those found in patients and that high-field
and short-echo-time in vivo 1H MRS can be used to investi-