European Psychiatry - Volume 41 - April 2017

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S550 25th European Congress of Psychiatry / European Psychiatry 41S (2017) S521–S582
Material and method We have selected a sample of 500 patients
who were in the 2nd year of secondary school to which has been
applied a battery of scales, including the EAT-26 scale for ED; and
has been collected socio-demographic data, including the use of
internet and mobile phone. We used SPSS to analyze the relation-
ship between these variables.
Results We have analyzed clinical and socio-demographic char-
acteristics of the sample. In relation to the risk of developing an
eating disorder we have found that high frequencies of use of the
Internet and high frequencies of use of mobile phones (especially
more than 4 hours a day) increases significantly the score in EAT-26
scale for ED (P < 0.05).
Conclusions Regarding the results, we can say that, in our sample,
the use of Internet and/or mobile phone more than 4 hours a day
significantly increases the probability of having a high score on the
scale for ED. This data can be essential when planning treatment or
establishing a preventive strategy.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV0448
The central role of body image in the
explanation of the engagement in
disordered eating attitudes and
behaviors
C. Ferreira ∗, A.L. Mendes , J. Marta-Simões
Faculty of Psychology and Education Sciences - University of
Coimbra, CINEIC, Cognitive Behavioral Center for Research and
Intervention, Coimbra, Portugal
∗ Corresponding author.
Shame is a universal emotion, that has been emphasized as a
pathogenic phenomenon in well-being and mental health. In
fact, although shame has been considered an adaptive defensive
response, higher levels of this painful emotion are strongly asso-
ciated with different mental health conditions. The current study
aimed to test whether the association of external shamewith eating
psychopathology would be explained by the mechanisms of body
image-related cognitive fusion, psychological inflexibility, and also
dietary restraint. A path analysis testing a mediational model was
conducted in a sample of 787 women from the general community,
aged between 18 and 51 years old. The tested model accounted
for 71% of the variance of eating psychopathology and revealed
an excellent fit to the data. Results demonstrated that external
shame’s impact on disordered eating attitudes and behaviors is
indirect, carried through increased body image-related cognitive
fusion, psychological inflexibility related to physical appearance,
and dietary restraint. These findings seem to support the associ-
ation between shame and eating psychopathology. Furthermore,
these data add to literature by suggesting that individuals who
present higher levels of shame may present increased tendency to
engage in dietary restraint and other maladaptive eating behav-
iors, through higher levels of body image-related psychological
inflexibility and cognitive fusion. The current study seems to hold
important clinical implications, highlighting the importance of
developing intervention programs in the community which target
shame and body image-related maladaptive attitudes and behav-
iors and, in turn, promote adaptive emotion regulation strategies
(e.g., acceptance abilities).
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV0449
Ghrelin response to hedonic eating in
underweight and short-term weight
restored patients with anorexia
nervosa
G. Fico ∗, A.M. Monteleone , M. Nigro , G. Patriciello ,
U. Volpe , P. Monteleone
1 Second University of Naples, Department of Psychiatry, Naples, Italy
2 University of Salerno, Department of Medicine and Surgery, Salerno,
Italy
∗ Corresponding author.
Introduction Recently, anorexia nervosa (AN) has been concep-
tualized as a reward-related disorder, and brain imaging studies
have shown functional and structural abnormalities in areas of the
brain involved in reward processes in both acute and recovered AN
patients. However, the role of endogenous biochemical mediators,
such as Ghrelin, in the modulation of reward processes has been
poorly investigated in this eating disorder.
Objectives Hedonic eating, that is the consumption of food exclu-
sively for pleasure and not to maintain energy homeostasis, is
a useful paradigm to investigate the physiology of food-related
reward.
Aims We assessed the Ghrelin response to food-related reward in
symptomatic ANwomen in order to further explore themodulation
of reward processes in this severe and debilitating disorder.
Methods Plasma levels of Ghrelin were measured in 7 under-
weight and 7 recently weight-restored satiated AN patients
before and after the ingestion of a favorite (hedonic eating) and
non-favorite (non-hedonic eating) food. Ghrelin responses were
compared it that of previously studied healthy controls.
Results We found that in satiated underweight patients with
AN plasma Ghrelin levels progressively decreased after the expo-
sure and the consumption of both the favorite and non-favorite
food whereas in satiated weight-restored AN patients and sati-
ated healthy controls plasma Ghrelin concentrations significantly
increased after the exposure to the favorite food and after eating it,
but decreased after the non-favorite food.
Conclusions These results suggest a derangement in the Ghre-
lin modulation of food-related pleasurable and rewarding feelings,
which might sustain the reduced motivation toward food intake of
acute AN patients.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV0450
Age at onset of eating disorders:
A statistical validation of proposed
cut-offs
G. Patriciello ∗, A.M. Monteleone , R. Amodio , M. Calvanese ,
U. Volpe , P. Monteleone
1 Second University of Naples, Department of Psychiatry, Naples, Italy
2 University of Salerno, Department of Medicine and Surgery, Salerno,
Italy
∗ Corresponding author.
Introduction Despite age at onset (AAO) of eating disorders (EDs)
has classically been described in adolescence; to date there is not
an univocal definition. While initial studies described a bimodal
distribution of AAO for ED, recently several studies didn’t confirm
these findings.
Objectives AAO thresholds definition for anorexia nervosa (AN)
and bulimia nervosa (BN) with statistical validation of proposed
cut-offs is highly needed, since AAO represents a crucial clinical
feature.
Aims We obtained data from subjects with AN and BN to perform
a normal distribution admixture analysis to determine their AAO.