European Psychiatry - Volume 41 - April 2017

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25th European Congress of Psychiatry / European Psychiatry 41S (2017) S710–S771 S751
eosinophilia have been described. This work describes a case of
transient eosinophilia caused by clozapine.
Methods Description of a clinical case.
Results A 22-year-old female patient, with a treatment resistant
psychotic disorder initiated clozapine in a slow titration to 300mg.
Ten days after initiating clozapine, the patient presented with
eosinophilia (started with 6.6 ×108/L and peaked at 10.0 ×108/L).
Two weeks later, the patient presented with a skin rash in the arms
and legs. The casewas discussedwith internal medicine service and
other causes of eosinophilia were excluded. Since the eosinophilia
was mild, the rash was not severe and the patient did not present
any other symptoms or signs, it was not considered necessary to
stop clozapine. During the next three months, with close monitor-
ing, the eosinophilia and the skin rash slowly resolved.
Conclusions This is a case of a patient who presented mild
eosinophilia and skin rash, associated to clozapine, with spon-
taneous resolution. We draw attention to the need of close
monitorization and exclusion of other causes of eosiniphilia
and rash. Furthermore, other hematologic disorders should be
considered besides agranulocytosis, namely eosinophilia, when
prescribing clozapine.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV1067
Polycystic ovarian syndrome in
patients with schizophrenia treated
with atypical anti-psychotics: A case
control study
V. De Silva ∗, A. Senanayake , S.S. Ratnatunga , S. Dissanayake ,
S. Gamage , S. De Silva , R. Hanwella , C. Wijeyaratne
1 Faculty of Medicine, University of Colombo, Psychiatry, Colombo, Sri
Lanka
2 NHSL, Psychiatry, Colombo, Sri Lanka
∗ Corresponding author.
Objective Objective was to compare the prevalence of probable
polycystic ovarian syndrome (PCOS) in females treated with atyp-
ical anti-psychotics with normal controls.
Aims To compare the prevalence of PCOS in patients treated with
atypical anti-psychotics and normal controls. To study the hormone
profiles in these two groups.
Methods Cases consisted of 102 reproductive age females with
schizophrenia treated with atypical anti-psychotics for ≥ 6months
and had gained ≥ 10% body weight. Control group was 123 age and
BMI matched females. Menstrual history, physical examination for
hirsuitism, acne, androgenic alopecia, anthropometrics measures,
Ultrasound abdomen and hormone analysis were done.
Results Mean age of cases = 33.17 years (SD 8.9) and con-
trols = 33.08 years (SD 5.6). Mean BMI of cases = 25.92 (SD 5.2) and
controls = 25.03 (SD 4.3). Polycystic ovarian morphology of ovaries
on ultra sound scan was significantly more in cases 49 (48%) than
controls 16 (13.%) (P < 0.001). Probable PCOS was significantlymore
in atypical anti-psychotic treated females (n = 22, 21.56%) than in
normal controls (n = 10, 8.13%) (P = 0.04). Atypical anti-psychotic
treated patients with PCOS had significantly lower mean LH levels
6.69mIU/L than those without PCOS 10.30 (P = 0.35). There was no
significant difference in testosterone, FSH, prolactin, TSH and free
T4 levels.
Conclusion Treatment with atypical anti-psychotics is associated
with higher prevalence of PCOS. This has not been reported previ-
ously. The hormonal profile in these patients may be different with
low testosterone and LH levels.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV1068
Unconventional side effects of
antidepressants: Focus on emotional
blunting
V. Falaschi ∗, S. Baroni , F. Mucci , H. Akiskal , D. Marazziti
1 Università di Pisa, Dipartimento di Medicina Clinica e Sperimentale,
Pisa, Italy
2 University of California, Department of Psychiatry, San Diego, USA
∗ Corresponding author.
Objectives The aimof this studywas to investigate the unconven-
tional side-effects of selective serotonin reuptake inhibitors (SSRIs)
and tricyclics (TCAs) antidepressants during long-term treatment
of depression, with a special focus on emotional blunting and, in
particular, on the possible changes of some features of loving rela-
tionships.
Methods Two hundred outpatients (130 women and 70 men,
mean age± SD: 43.4 ±11.1 years) were enrolled. They were suffer-
ing frommild or moderate depression, according to DSM–5 criteria,
treatedwithone antidepressant for at least sixmonths and involved
in a long-term loving relationship. A specifically designed test, the
so-called “sex, attachment, love” (SALT) questionnaire was built to
assess the possible changes of the loving relationship.
Results The results showed differences between the two genders,
in particular women taking TCAs reported more sexual side effects
thanmen, whereas men taking SSRIs complained a reduction of the
feelings of love and attachment towards the partner.
Conclusions Antidepressants seem to have a dimorphic effect on
some elements of loving relationships, however these results need
to be further explored.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV1069
Citalopram–induced delusions in an
older adult
J. Fennema ∗ etrykiv e Jonge Arts
1 GGZ Friesland, Geriatric Psychiatry, Leeuwarden, The Netherlands
2 University of Groningen, University Medical Center Groningen,
Department of Clinical Pharmacy and Pharmacology, Groningen, The
Netherlands
3 Leonardo Scientific Research Institute, Department of Geriatric
Psychiatry, Groningen, The Netherlands
4 University of Groningen, University Medical Center Groningen,
Department of Old Age Psychiatry, Groningen, The Netherlands
∗ Corresponding author.
Introduction Selective serotonin reuptake inhibitors (SSRIs) are
the most prescribed antidepressants worldwide. In older adults,
citalopram is generally well tolerated and safe in the therapeutic
dose range of 20 to 40mg/day. In literature, there are cases of SSRI-
induced psychosis, but mainly with fluoxetine. There are only three
reported cases of citalopram-induced delusions, however, these
case-reports did not involve an older adult.
Objectives and aims To provide a case of citalopram–induced
psychosis in an older adult, followed by the review of available
literature.
Methods A case report is presented and discussed followed by a
literature review.
Results A 64-year-old woman without somatic illnesses was
referred by a general practitioner with depressive symptoms. One
week after initiation of citalopram 10mg/day she suddenly devel-
oped delusions, predominantly in the early morning. No other
medical evidence was found that could explain her delusions. After
discontinuation of citalopram her delusions quickly resolved.
Conclusion This is the first case report of a SSRI-induced delu-
sion in an older adult. Citalopram has been reported to be one of