European Psychiatry - Volume 41 - April 2017

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25th European Congress of Psychiatry / European Psychiatry 41S (2017) S170–S237 S185
sent an “invisible” at risk group. Results also suggest that global
anti-stigma campaigns in universities may not prove effective in
encouraging help seeking.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
e-Poster walk: Schizophrenia and other psychotic
disorders–part 1
EW0232
Formal thought disorder in
schizophrenia and bipolar disorder: A
systematic review and meta-analysis
K. Alptekin ∗, B. Yalincetin , E. Bora , A. Berna
1 Dokuz Eylul University, Psychiatry, Izmir, Turkey
2 Medical Sciences, Neuropsychiatry, Izmir, Turkey
∗ Corresponding author.
Historically, formal thought disorder has been considered as one
of the distinctive symptoms of schizophrenia. However, research
in last few decades suggested that there is a considerable clini-
cal and neurobiological overlap between schizophrenia and bipolar
disorder (BP). We conducted a meta-analysis of studies compar-
ing positive (PTD) and negative formal thought disorder (NTD)
in schizophrenia and BP. We included 19 studies comparing 715
schizophrenia and 474 BP patients. In the acute inpatient sam-
ples, there was no significant difference in the severity of PTD
(d = –0.07, CI = –0.22–0.09) between schizophrenia and BP. In stable
patients, schizophrenia was associated with increased PTD com-
pared to BP (d = 1.02, CI = 0.35–1.70). NTD was significantly more
severe (d = 0.80, CI = 0.52–0.1.08) in schizophrenia compared to BP.
Our findings suggest that PTD is a shared feature of both schizophre-
nia and BP but persistent PTD or NTD can distinguish subgroups
of schizophrenia from BP and schizophrenia patients with better
clinical outcomes.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0233
The split version of Global Assessment
of Functioning scale – application and
utility in remitted psychotic patients
S. Andric ∗, M. Mihaljevic , T. Mirjanic , N. Maric
1 University of Belgrade, Faculty of Medicine, Dpt. for Research and
Early Interventions in Psychiatry, Belgrade, Serbia
2 Clinic for Psychiatry, Clinical Centre of Serbia, Research and Early
Interventions in Psychiatry, Belgrade, Serbia
3 Special hospital for Psychiatric disorders Kovin, Psychosis, Kovin,
Serbia
4 Clinic for Psychiatry Clinical Center of Serbia, Research and Early
Interventions in Psychiatry, Belgrade, Serbia
∗ Corresponding author.
Introduction Current knowledge about the advantages of using
split version of GAF scale – having separate Symptom (GAF-S) and
Functioning (GAF-F) subscales is insufficient and has number of
gaps. Present study analyzed the manner in which young adult
remitted psychotic patients with different functional levels vary in
their symptom severity and how GAF-F reflects presence/absence
of well-known psychosis risk factors.
Methods Sample comprised 37 remitted psychotic patients
(56.8% male, 29.4 ± 6.1 years), categorized based on GAF-F scores
into groups: ‘Moderate remission’ (GAF-F 41–60, n = 19) and “Good
remission” (GAF-F > 61, n = 18). Participants were assessed using
the GAF-S, WAIS-R, NottinghamOnset Schedule, Premorbid Adjust-
ment and Brief Core Schema scales, childhood trauma and bullying
questionnaires. Mann–Whitney and Student’s t-tests were used to
assess between-group differences.
Results Groups did not differ in age, sex and education. When
compared to “Good remission” group, “Moderate remission”
group exhibited earlier illness’ onset (P = 0.01), greater symptom
severity (P = 0.00), negative self-evaluation (P = 0.02), more child-
hood physical abuse (P = 0.01) and bullying (P = 0.01). Moreover,
trend-like significances (P = 0.08) were observed for poorer ado-
lescence adjustment and negative evaluation of others. There
were no between-group differences regarding IQ and duration of
untreated/treated illness.
Conclusions GAF scale is in the continual use since early 1990,
however, evidence of further development of the instrument itself
is sparse. Present research is demonstrating that GAF-F scores
reflect diverse factors related to psychosis risk, the illness’ course
and quality of remission. Moreover, the results contribute to sur-
mount some of the gaps in knowledge about the split version of
GAF scale.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0234
C-reactive protein and parathyroid
hormone in acute severe psychotic
disorders (schizophrenia, bipolar
disorder and
methamphetamine-induced psychotic
disorder)
S. Arya ∗ hmadkhaniha lavi rya arei
1 Iran University of Medical Sciences, Mental Health Research Center,
Tehran, Iran
2 Golestan University of Medical Sciences, Department of General
Surgery, Gorgan, Iran
∗ Corresponding author.
Introduction and objectives Schizophrenia accompanies with
elevated C-reactive protein (CRP) and vitamin D deficiency. How-
ever, there are scarce documentations regarding bipolar disorder
and methamphetamine-induced psychotic disorder.
Aim To compare serum levels of vitamin D, parathyroid hormone
(PTH), calcium, phosphorus and CRP levels in psychotic disorder
patients and control group.
Methods A case-control study was conducted on four groups:
acute phase of schizophrenia, acute manic episode of bipolar dis-
order, methamphetamine-induced psychotic disorder and healthy
control subjects. Sample size was 45 in each group. Weekly dura-
tion of sun exposure, monthly vitamin D intake and serum levels
of vitamin D, calcium, phosphorus, PTH and CRP were assessed.
Brief Psychiatric Rating Scale (BPRS) was used to evaluate psychotic
symptoms.
Results Duration of sun exposure and monthly vitamin D intake
were comparable among groups. Serum levels of vitaminD, calcium
and phosphorus were not statistically different between groups
(P = 0.463, P = 0.086 and P = 0.339, respectively). Serum levels of PTH
were significantly higher in control group (P < 0.001). CRP levels
were significantly lower in control subjects (P < 0.001). The levels
of serum vitamin D and CRP did not show statistically significant
difference among three groups of patients.
Conclusion Acute psychotic disorders seem to be associated with
higher CRP and lower PTH levels. Clinical importance of the findings