European Psychiatry - Volume 41 - April 2017

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S188 25th European Congress of Psychiatry / European Psychiatry 41S (2017) S170–S237
Conclusions A decreased ability to identify emotions is directly
correlated with decreased social functioning in subjects with
schizophrenia spectrum disorders.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0241
Long acting antipsychotics treatment
of schizophrenia: A 24-month
prospective study on patient’s attitude
towards treatment
E. Calderani ∗, F. Pietrini , I. Burian , F. Chiarello , D. Dahlke ,
S. Gemignani , P. Marino , G.A. Talamba , L. Poli , A. Santangelo ,
V. Ricca , A. Ballerini
University of Florence, Neuro. Far. Ba, University of Florence,
Florence, Italy
∗ Corresponding author.
Introduction Long-acting injectable (LAI) second-generation
antipsychotics (SGAs) are considered an alternative to oral antipsy-
chotics for schizophrenic patients with low adherence to therapy.
However, it is still a matter of debate whether LAI-SGAs are able to
significantly improve patient’s attitudes towards treatment (ATT)
Objective To investigate the impact of LAI on ATT over 24months.
Methods Nineteen schizophrenic patients were switched from
either oral olanzapine (11) or paliperidone (8) to the corresponding
LAI. Patients were assessed at baseline (T0), after 6 (T1), 12 (T2) and
24 months (T3). Drug Attitude Inventory-10 (DAI-10) as used
to assess ATT. Young Mania Rating Scale (YMRS), Montgomery-
Asberg Depression Rating Scale (MADRS), Positive and Negative
Syndrome Scale (PANSS), and Short Form Health Survey (SF-36)
were used for psychopathology evaluations.
Results Eleven patients reached T3. Eight patients were excluded
(4 olanzapine, 4 paliperidone): 4 required a significant change in
concomitant treatment, 4 a change of antipsychotic (metabolic
comorbidity). No changes in psychopathology occurred between
T2 and T3, some scales improved from baseline to T2. DAI-10 mean
scores were improved after 12 months, thus not significantly, and
were further improved at 24 months (P = .008 vs baseline).
Conclusions ATT keeps improving after one year of LAI treatment,
unrelated to clinical response.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
References
[1] Kaplan G, Casoy J, Zummo J. Impact of long-acting injectable
antipsychotics onmedication adherence and clinical, functional,
and economic outcomes of schizophrenia. Patient Prefer Adher-
ence 2013;7:1171–80.
[2] Nielsen RE, Lindström E, Nielsen J, Levander S. DAI-10 is as
good as DAI-30 in schizophrenia. Eur Neuropsychopharmacol
2012;22(10):747–50.
EW0242
Relationship between cognition and
primary negative symptoms
sub-domains in schizophrenia
O.O. Capatina ∗, I.V. miclutia , A. toma
1 University of Medicine and Pharmacy Iuliu Hatieganu, Psychiatry,
Cluj-Napoca, Romania
2 Psychiatry City Hospital Tarnaveni, Psychiatry, Tarnaveni, Romania
∗ Corresponding author.
Introduction The relationship between negative symptoms and
cognition in schizophrenia is not clear, a number of authors whom
studied this relationship came up with inconsistent findings and
meta-analyses show that there is a small moderate associations
between the two domains.
Objectives and aims The aim of this study was to investigate the
relationship between cognition and the primary negative symp-
toms sub-domains.
Methods Sixty-seven female patients with schizophrenia were
evaluated using PANSS ans NSA-16 scales. Correlation and regres-
sion analyses were used in the present study to investigate
the relationship between the primary negative symptoms sub-
domains obtained by using the principal component analysis, and
cognition evaluated with the PANSS using the 5 factor model as
described by Lindenmayer.
Results No relationship was found between the PANSS Cognitive
factor and Negative factor, but when investigating the relation-
ship of the Cognitive PANSS factor with the negative sub-domains:
diminished expression (DE) and avolition-apathy (AA), it was
shown that there is a significant association between cognition
and AA domain, but there was shown no association with the DE
domain, and there was just a small association with the composit
score of the NAS-16.
Conclusions Our study reveals the relative independence of cog-
nitive factor from the negative domain of the psychopathology,
even though the association with AA domain was clear. These find-
ings also support the need of using appropriate assessment tools
in order to get a refined understanding of the phenomenology of
schizophrenia.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0243
Assessing suicide risk with the Clinical
Interview for Psychotic Disorders
(CIPD): Preliminary reliability and
validity of the Suicide Risk Scale for
Psychosis (SRS-P)
M.J. Martins astilho arvalho ereira
J. Gonc¸ alves , R. Guiomar , C. Marques , A. Pinto ,
D. Carreiras ∗, M. Bajouco , A. Macedo
1 Faculty of Psychology and Educational Sciences, University of
Coimbra, CINEICC, Coimbra, Portugal
2 University of Azores, Portugal, Department of Educational Sciences,
Ac¸ ores, Portugal
3 Faculty of Medicine, University of Coimbra, Psychological Medicine
Department, Coimbra, Portugal
∗ Corresponding author.
Background Suicide risk is an important variable to consider both
in assessment and throughout the therapeutic process in psychotic
disorders. The SRS-P is an 18-item scale computed from the patient
and clinician-rated scores obtained in the CIPD. The scale comprises
lifetime assessment of depressed mood, anhedonia and its current
interference and severity, current and past feelings of hopeless-
ness, suicidal ideation, ‘voices’ about suicide, and suicide-related
behaviors.
Aims To assess reliability and convergent validity of the SRS-P in
a sample of participants with psychosis.
Methods The sample comprised 22 participants (68.2% male),
single (72.7%), between 19 and 47 years old (M= 31.05; SD = 7.088),
with 4–17 years of education (M= 11.77; SD = 3.176), employed
(50%). The most prevalent diagnosis was schizophrenia (68.2%) and
the participants had a mean of 1.90 hospitalizations (SD = 2.548).
The mean age of illness onset was 23.57 years (SD = 5.555). The
participants were assessed with the CIPD, Depression, Anxiety and
Stress Scales-21, Forms of Self-Criticism and Reassurance Scale,
Self-Compassion Scale, Other as Shamer Scale and the Empower-
ment with Psychotic Symptoms Scales.