European Psychiatry - Volume 41 - April 2017

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S186 25th European Congress of Psychiatry / European Psychiatry 41S (2017) S170–S237
and relation of these differences to themetabolic and inflammatory
bases of psychosis are not clear yet.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0235
Long-term rates of remission and late
psychotic transition of individuals at
risk for psychosis
K. Beck ∗ ndreou tuderus gloff Heitz
S. Menghini-Müller ttig eanza Uttinger
A. Simon , S. Borgwardt , A. Riecher-Rössler
1 University of Basel Psychiatric Hospital, Center for Gender Research
and Early Detection, Basel, Switzerland
2 Hospitals of Solothurn, Psychiatric Services of Solothurn,
Solothurn/Olten, Switzerland
3 Specialized Early Psychosis Outpatient Service for Adolescents and
Young Adults, Department of Psychiatry, Bruderholz, Switzerland
4 University of Basel Psychiatric Hospital, Department of Psychiatry,
Basel, Switzerland
∗ Corresponding author.
Introduction In the growing research field of early psychosis
detection in patients with an at risk mental state (ARMS), most
studies focus on the transition to frank psychosis. However, the
majority of ARMS patients do not go on to develop frank psy-
chosis and reported transition rates are declining. Little is known
about the long-term outcome of these non-transitioned patients
(ARMS-NT).
Objectives To investigate in preliminary analyses the long-term
outcome of ARMS-NT patients with respect to persistence of ARMS
signs and symptoms and the rates of late psychotic transition.
Methods The ongoing study “FePsy-BHS-NT” follows up ARMS-
NT without transition during at least the first two years for up to
15 years after their initial assessment. ARMS status is ascertained
with the Basel Screening Instrument for Psychosis (BSIP). ARMS
remission is defined as the absence of attenuated psychotic symp-
toms or brief limited intermittent psychotic symptoms for at least
12 consecutive months.
Results In this preliminary sample of 51 ARMS-NT, the majority
of patients (70.6%) have remitted from their at risk mental state,
13.7% remain at risk and 15.7% have made a late psychotic transi-
tion during the course of long-term follow up (median = 5.75, range
4–11 years after initial assessment).
Conclusions The considerable rates of ARMS persistence and
late psychotic transition indicate that longer follow-up durations
than commonly recommended should be contemplated in ARMS
patients. Potential predictors of favorable long-term clinical out-
come, as well as psychosocial, neurocognitive and other outcomes
of ARMS-NT patients will be further evaluated in the present
study.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0236
Acute psychotic disorders: Factors
related to schizophrenia evolution
R. Ben Soussia ∗, A. Bouallagui , I. Marrag , S. Khouadja , S. Younes ,
M. Nasr
CHU Tahar Sfar, Psychiatry, Mahdia, Tunisia
∗ Corresponding author.
Introduction Acute psychotic disorders are described as a clin-
ical syndrome characterized by Acuteness of the installation, the
intensity and the polymorphism of delirium.
Aim Describe the demographic characteristics of a population
of patients with an acute psychotic disorder and identify factors
correlated with evolution to schizophrenia.
Methods This is a retrospective, descriptive and analytic study
conducted on hospitalized patients in psychiatric department EPS
Mahdia for acute psychotic disorder according to DSM-VI-TR crite-
ria. A study of the recurrence time was performed by Kaplan–Meier
and Cox test was used to identify factors correlated with evolution
to schizophrenia.
Results One hundred and eleven patients were collected. The
average age of the study population was 27 years, a male predom-
inance was noted (59.5%), 39.6% of patients had family history
of psychiatric disorders, including schizophrenic disorders and
bipolar disorder were the most common with rates of 63.6 and
18.4% of cases. For our patients, 38.7% progressed to schizophre-
nia. Four risk factors were significantly predictive of progression
to schizophrenia: male gender (P= 0.026), subacute or progres-
sive onset disorders (P = 0.003), partial remission of the disorder
(P = 0.023) and the prolonged duration of untreated psychosis
(P = 0.027).
Conclusion The evolution of an acute psychotic disorder remains
unpredictable. In fact, the severity is related to the risk of devel-
oping schizophrenia or mood disorder. Attention is paid in recent
years to recognize and seek most precociously as possible factors
associated with this evolution.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0237
Acute psychotic disorder:
Which future?
R. Ben Soussia ∗, A. Bouallagui , S. Younes , I. Marrag , M. Nasr
CHU Tahar Sfar, Psychiatry, Mahdia, Tunisia
∗ Corresponding author.
Introduction At present, in absence of reliable clinical and evolu-
tionary data, it is difficult to determine what the consequences of
an acute psychotic disorder, specifically if it is a mode of entry into
schizophrenia, a mood disorder or a short-lived episode.
Aim The objective of this study was to describe the sociodemo-
graphic characteristics and evolutionary modalities of a population
of patients with a first psychotic episode.
Methods This is a retrospective descriptive study, which involved
patients admitted to psychiatric ward EPS Mahdia for acute psy-
chotic disorder according to DSM-VI-TR criteria. Data collection
was conducted from archived observations and through a pre-
determined sheet.
Results One hundred and eleven patients were collected. The
average age of the study population was 27 years, a male predom-
inance was noted (59.5%), 52.3% were from urban, 73% of patients
were single, 33.3% were from a consanguineous marriage. Among
those patients with a first acute psychotic episode, 43 patients
(38.7%) progressed to schizophrenia, 15.3% to bipolar disorder, 23,
4% to recovery while 22.5% were lost view.
Conclusion The long-term evolution of an acute psychotic disor-
der remains unpredictable. In fact, the severity is related primarily
to the risk of developing a schizophrenic disorder or a mood disor-
der. In this context, attention is paid in recent years to recognize and
seek the earliest possible factors associated with this development.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.