European Psychiatry - Volume 41 - April 2017

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S192 25th European Congress of Psychiatry / European Psychiatry 41S (2017) S170–S237
2 Newcastle University, School of Psychology, Newcastle upon Tyne,
United Kingdom
3 Tees Esk and Wear Valleys NHS Foundation Trust, Early
Intervention in Psychosis, Durham, United Kingdom
4 Newcastle upon Tyne Hospitals NHS Foundation Trust, Early
Intervention, Newcastle upon Tyne, United Kingdom
5 University of Warwick, Division of Mental Health and Wellbeing,
Warwick Medical School, Warwick, United Kingdom
∗ Corresponding author.
Objectives Evidence from meta-analyses of randomised clinical
trials shows interventions for young people at ultra-high risk (UHR)
of developing psychosis are effective both clinically and econom-
ically. While research evidence has begun to be integrated into
clinical guidelines, there is a lack of research on the implemen-
tation of these guidelines. This paper examines service provision
for UHR individuals in accordance with current clinical guidelines
within the National Health Service (NHS) in England.
Method A self-report online survey was completed by clinical
leaders of Early Intervention in Psychosis (EIP) teams (n = 50) within
the NHS across the UK.
Results Of the 50 EIP teams responding (from 30 NHS Trusts),
53% reported inclusion of the UHR group in their service mandate,
with age range predominantly 14–5 years (81%) and service pro-
vided for at least 12 months (53%). Provision of services according
to NICE clinical guidelines showed 50% of services offered cog-
nitive behavioural therapy (CBT) for psychosis, and 42% offered
family intervention. Contrary to guidelines, 50% of services offered
antipsychotic medication. Around half of services provided train-
ing in assessment by CAARMS, psycho-education, CBT for psychosis,
family work and treatment for anxiety and depression.
Conclusions Despite clear evidence for the benefit of early inter-
vention in this population, current provision for UHR within EIP
services in England does not match clinical guidelines. While some
argue this is due to a lack of allocated funding, it is important to
note the similar variable adherence to clinical guidelines in the
treatment of people with established schizophrenia.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
e-Poster walk: Schizophrenia and other psychotic
disorders–part 2
EW0254
Effects of chronic antipsychotic
treatment on neurophysiological
correlates of the auditory oddball task
in schizophrenia: A preliminary
report from a multicentre study
G. Di Lorenzo ∗, A. Mucci , A. Vignapiano , G. Giordano ,
F. Ferrentino , C. Niolu , M. Altamura , D. Marasco ,
S. Galderisi
1 University of Rome, Tor Vergata, Department of Systems Medicine,
Rome, Italy
2 University of Naples SUN, Department of Psychiatry, Naples, Italy
3 University of Foggia, Department of Clinical and Experimental
Medicine, Foggia, Italy
∗ Corresponding author.
Introduction The effects of chronic antipsychotic administration
on the human brain are debated. In particular, first-generation
(FGAs) and second-generation antipsychotics (SGAs) seem to have
different impacts on brain function and structure in subjects with
schizophrenia. Few studies have investigated the effect of chronic
administration of FGAs and SGAs on indices of brain function, such
as event-related potentials (ERP) or neuropsychological perfor-
mance.
Objectives Within the Italian Network for Research on Psychoses
study, subjects stabilized on FGAs or SGAs were compared on P300,
an ERP component, thought to reflect attention, working memory
and context integration and on neurocognitive indices.
Methods ERPs were recorded in 110 chronic, stabilized patients
with Schizophrenia (28 used FGAs) during a standard auditory odd-
ball task. P300 latency and amplitude were assessed at Pz channel.
MATRICS Consensus Cognitive Battery (MCCB) was used for cogni-
tive assessment.
Results Comparedwith the SGAs group, patients on FGAs showed
significant increased P300 latency (P = 0.003; Cohen’s d = 0.67) and
significant decreased P300 amplitudes ( P= 0.023; Cohen’s d = 0.38).
The two groups did not differ on psychopathology andMCCB scores.
Multiple linear regressions revealed that “FGAs vs. SGAs” (ˇ = 0.298,
P = 0.002) and MCCB neurocognitive composite T-score (ˇ = –0.273,
P = 0.004) were independent predictors of P300 latency, whereas
only age (ˇ = –0.220, P = 0.027) was an independent predictor of
P300 amplitude.
Conclusions FGAs seem to affect the functional brain activity
more than SGAs, particularly slowing cortical processing. Our
results suggest that discrepant findings concerning P300 latency in
schizophrenia might be related to the type of antipsychotic treat-
ment used. Longitudinal studies are needed to further address this
issue.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0255
Schizophrenia and major depression:
Resilience, coping styles, personality
traits, self-esteem and quality of life
S. Di Marco ∗ eggi ammarata irardi ert
G. Scaioli ramaglia eppegno
1 UPO–Università degli Studi del Piemonte Orientale- Novara,
Traslational medicine, Novara, Italy
2 Università degli Studi di Torino, Department of Public Health and
Paediatric Sciences, Torino, Italy
∗ Corresponding author.
Introduction Resilience is commonly defined as positive adap-
tation to adverse events or as the ability to maintain or regain
mental health after exposure to difficulties. According to the
bio-psycho-social model, resilience is influenced by self-esteem,
coping strategies and personality traits. In schizophrenic patients,
resilience seems to affect real-life functioning, while in mood dis-
orders, resilience influences the longitudinal course of the disorder,
reducing the frequency of relapses and improving drugs response.
Objectives The aimof this study is to asses levels of resilience and
self-esteem, coping strategies, perceived quality of life and temper-
ament characteristics in a sample composed by patients withmajor
depressive disorder and patients affected by schizophrenia.
Methods We collected a sample composed by 40 patients with
major depressive disorder and 40 patients affected by schizophre-
nia patients recruited at the “Maggiore della Carità” Hospital
in Novara, Italy. The assessment protocol included: Resilience
Scale for Adults (RSA), Coping Orientation to Problems Experi-
enced Inventory–Brief (BRIEF–COPE), Rosenberg Self-esteem Scale
(RSES), Paykel List Of Stressful Events, Temperamental and Char-
acter Inventory (TCI) and Short form 36 (SF-36). Comparison of
qualitative data was performed by means of the 2, a t-test was
performed for continuous normal-distribution variables otherwise
a non-parametric Mann–Whitney test was performed. Statistical
significance was set at P ≤ 0.05.