European Psychiatry - Volume 41 - April 2017

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25th European Congress of Psychiatry / European Psychiatry 41S (2017) S170–S237 S195
Methods An observational cohort study of unselected patients
with schizophrenia visiting outpatient facilities in the Region of
Central Jutland, Denmark. Patients were enrolled from January
2013 through March 2015 with follow-up until June 2015. Data
was collected from clinical interviews and clinical case records.
Results ECGs were available in 58 patients receiving antipsy-
chotic treatment. We observed no difference in average QTc
interval for the whole sample of patients receiving monotherapy or
polypharmacy (P = 0.29). However, women presented longer QTc-
interval on polypharmacy than on monotherapy (P = 0.01).
Conclusion We recommend an increased focus onmonitoring the
QTc interval inwomanwith schizophrenia receiving antipsychotics
as polypharmacy.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0262
Postural control and executive
functioning in patients with
schizophrenia
M. Yildirim , A. Elvan , G. Ercegil ∗, I.E. Simsek , S. Savci ,
K. Alptekin
1 Dokuz Eylul University, School Of Physical Therapy And
Rehabilitation, Izmir, Turkey
2 EGE University, Psychology Department, Izmir, Turkey
3 Dokuz Eylul University, Psychiatry Department, Izmir, Turkey
∗ Corresponding author.
Introduction Patients with schizophrenia commonly show
deficits in executive functioning that allow a person to make
plans, solve problems, do many tasks simultaneously and adapt
to unexpected conditions. Executive dysfunction is associated
with very simple and automatic activities, such as walking in
schizophrenia patients. However, no study exists about its relation
to postural control in these patients.
Aim To investigate the effect of executive functioning on postural
control using dual task paradigms.
Methods Fifteen clinically stable schizophrenia outpatients and
15 healthy controls were enrolled in the study. Postural control
was assessed with bilateral stance test using the Balance Master
system under three different conditions with eyes open and eyes
closed (EC): without a task, during a cognitive task (verbal fluency)
and during a motor task (holding a cup of water).
Results Standing on a foam surface with EC resulted in higher
postural sway velocities in schizophrenia patients under all condi-
tions (P = 0.009, P = 0.032, P = 0.013). During a cognitive task, both
schizophrenia patients and healthy controls showed higher veloci-
ties on firm surface with EC in comparison to the condition without
a task (P = 0.023). Both schizophrenia patients and healthy controls
did not showhigher postural sway velocities during themotor task.
Conclusion The effect of verbal fluency on postural sway shows
the relationship between executive functioning and postural con-
trol in schizophrenia patients. Foam surface also higher postural
sway velocities in schizophrenia patients in EC condition suggest-
ing the difficulties in integrating the proprioceptive information in
the absence of visual input.
Keywords Executive functioning; Schizophrenia; Postural
control
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0263
Patients with severe schizophrenia.
functioning improvement after 7-year
of comprehensive treatment
J.J. Fernandez-Miranda ∗ íaz-Fernández . Frías-Ortiz
1 SESPAsturian Mental Health Service, AGCSM-V, Gijon, Spain
2 SESPAsturian Mental Health Service, AGCSM-V, Gijón, Spain
∗ Corresponding author.
Introduction To reach not only clinical but also rehabilitation
(especially to improve psychosocial functioning) goals in people
with schizophrenia is a need.
Objective To know the retention in treatment and functional out-
comes of patients with severe schizophrenia enrolled in a specific
and comprehensive programme for 7 years.
Method A 7-year prospective, observational study of patients
with severe schizophrenia (CGI-S of 5 or over) undergoing com-
prehensive programme (n = 200). Assessment included at the
beginning and after 3, 6, 12, 24, 36 and 84 months: the CGI-S, the
Camberwell Assessment of Needs (CAN) and the WHO-DAS. Time
in treatment, reasons for discharge, laboratory tests, weight, medi-
cations, adverse effects and hospital admissions in the previous six
years and during the follow-up were registered.
Results CGI at baseline was 5.9 (0.7). After seven years, 44%
of patients continued under treatment (CGI = 4.3 (0.8); P < 0.01);
36% were medical discharged (CGI = 3.4 (1.5); P < 0.001); WHO-DAS
decreased in the four areas (P < 0.005) and also CAN (P < 0.01); 8%
were voluntary discharges. Ten patients dead; three of them com-
mitted suicide (1.5%). Hospital admission decreased significantly
(P < 0.001), and also antipsychotic combinations and antiparkinso-
nianmedications. Fifty-five percent of all of themwere treatedwith
atypical long-acting antipsychotics, with good tolerability and few
side effects (among them, only 4% were voluntary discharges).
Conclusion Retention of patients with schizophrenia with severe
symptoms and impairment in a specific and comprehensive pro-
gramme was really high. Such good treatment adherence helped to
get remarkable clinical and functional improvement. Long-acting
medication seemed to be useful in improving treatment adherence.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0264
Extrapyramidal side effects and
functional remission in schizophrenia
B. Ghajati ∗, C. Leila , L. Raja , C. Majda
1 Razi Hospital, Psychiatry Department “C”, Tunis, Tunisia
2 Razi Hospital, Psychiatry Department “E”, Tunis, Tunisia
∗ Corresponding author.
Treating patients with schizophrenia has evolved towards includ-
ing, as an effective goal, their functional remission. Beyond the
discrepancies in this concept definition, a plethora of studies
has been conducted trying to identify predictors of functioning
in schizophrenia. Among which antipsychotic prescription and
related side effects.
Aim Explore extrapyramidal side effects link with functional
prognosis of patients with schizophrenia spectrum disorder.
Methods We conducted a cross-sectional, retrospective and
descriptive study in the psychiatry department “C”, in Razi hospi-
tal (Tunis), between October 2014 and March 2015. Sixty patients
suffering from schizophrenia spectrum disorder (DSM IV-R) were
included. Functional status was explored with the Global Assess-
ment of Functioning Scale (GAF), the Social and Occupational
Functioning Assessment Scale (SOFAS) and the Social Autonomy
Scale (EAS). Extrapyramidal side effects (EPS) were evaluated using
the Simpson and Angus Rating Scale (SAS).
Results Functional remission was achieved according to GAF,
SOFAS and EAS in respectively: 63,30%, 48,30% and 51,70% of the
patients. SAS mean score was 0.898± 0.29 (0.4–2). Although SAS
showed no significant association with GAF, SOFAS and EAS global
scores, patientwith less EPS hadbetter autonomy inEAS’ dimension
“Relationship with the outside” (P = 0.048).