European Psychiatry - Volume 41 - April 2017

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25th European Congress of Psychiatry / European Psychiatry 41S (2017) S238–S302 S269
between the two groups regarding the different socio-demographic
variables and the age of onset of disease. Significant difference was
found between the two groups regarding: personal antecedents of
attempt of homicide a (P < 0.003), personal antecedents of attempt
of suicide (P< 0.001), a history of previous violence (P = 0.005),
untreatedpsychosis before the act (P < 0.001) poormedication com-
pliance and a low familial support (P< 0.001), antisocial behavior
(P < 0.001), addictive behavior (P = 0.007).
Conclusion Awareness of these factors will allow us to provide
improved prevention of violence within schizophrenic subjects.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0478
Elevated C-reactive protein levels
associated with aggressive behavior in
Moroccan patients with schizophrenia
A. Kachouchi ∗, D.S. Said , P.A. Imane , P.M. Fatiha , P.A. Fatima
University hospital Mohammed VI, Department Of Psychiatry,
Marrakech, Morocco
∗ Corresponding author.
Background Recent studies reported an association between
aggression and inflammation. In this study, we examined the asso-
ciation between aggressive behavior and inflammatory markers
(serum levels of CRP) in schizophrenia inpatients.
Methods Adult schizophrenia inpatients (n = 145) were prospec-
tively identified and categorized according to their C-reactive pro-
tein measurement at admission as either elevated (CRP > 1mg/dL;
n = 45) or normal (CRP < 1mg/dL; n = 100). The following indi-
cators of aggression were compared: PANSS excitement com-
ponent (PANSS-EC), restraints and suicidal behavior during
hospitalization.
Results The results show that patients with elevated CRP levels
are more aggressive during hospitalization as detected by statis-
tically significant higher scores of aggressive behavior (PANSS-EC
score), and by increased rates of physical restraint during hospital-
ization. No statistically significant differences in the other clinical
features, including suicidal behavior.
Conclusion Our results are consistent with previous findings
linking schizophrenia to activation of the inflammatory response
system.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0479
Relationship between childhood
trauma and psychotic symptoms in
patients with schizophrenia
E.E. Kılıc¸ aslan ∗, A. Esen , M. Izci Kasal , E. Ozelci , B. Murat ,
M. Gulec
1 Izmir Katip C¸ elebi University Ataturk Training and Research
Hospital, Psychiatry, Izmir, Turkey
2 Izmir Tepecik Training and Research Hospital, Psychiatry, Izmir,
Turkey
3 Van YuzuncuYil University, Psychology, Van, Turkey
∗ Corresponding author.
Introduction The association between childhood trauma and
psychotic symptoms is still not clearly understood. Findings for
positive and negative symptoms are confounding. This symp-
tomatic response may differ according to the type of childhood
trauma, for example childhood abuse was associated with positive
symptoms while childhood neglect was associated with negative
symptoms.
Objectives This study examined the relationship between child-
hood trauma and psychotic symptoms in schizophrenic patients
after controlling for the possible confounding factors, such as clin-
ical features, depression, and sleep quality.
Methods The childhood trauma questionnaire – short form, Pos-
itive and Negative Syndrome Scale (PANSS), Calgary Depression
Scale for Schizophrenia, Pittsburgh sleep quality index, and the sui-
cidality subscale of mini-international neuropsychiatric interview
were administered to 199 patients with schizophrenia. We used
sequential multiple stepwise regression analyses in which positive
symptoms, negative symptoms, overall psychopathology and total
symptoms of schizophrenia were dependent variables.
Results Depressive symptomatology and childhood physical
abuse (CPA) significantly contributed to positive, negative, gen-
eral psychopathology and global schizophrenia symptomatology.
Stepwise regression analysis results are presented in
Conclusions Our findings suggest that CPA during childhood
could have an impact on psychopathology in schizophrenia.
Table 1 Stepwise regression analysis results.
Depressive
symptomatology
Childhood
physical abuse
Positive symptoms = 0.29, t = 4.051
P < 0.001
= 0.20, t = 3.160
P < 0.01
Negative symptoms = 0.30, t = 4.575
P < 0.001
= 0.14, t = 2.214
P < 0.05
General
psychopathology
= 0.53, t = 8.966
P < 0.001
= 0.17, t = 2.939
P < 0.01
PANNS Global = 0.46, t = 7.643
P < 0.001
= 0.20, t = 3.343
P < 0.01
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0480
Quality of life in healthy siblings of
patients with first episode of
psychotic illness and its predictors
P. Knytl ∗, V. Vorackova , P. Mohr
1 National Institute of Mental Health Czech Republic, Diagnostics and
Treatment of Mental Disorders, Klecany, Czech Republic
2 3rd Faculty of Medicine, Charles University in Prague, Postgradual
student, Prague, Czech Republic
3 National Institute of Mental Health Czech Republic, Applied
Neurosciences and Brain Imaging, Klecany, Czech Republic
4 3rd Faculty of Medicine, Charles University in Prague, Departement
of Psychiatry and Clinical Psychology, Prague, Czech Republic
∗ Corresponding author.
Families of patients with first episode of psychotic illness are
exposed to numerous distress factors related to the care of their
relative. It has been shown that these families experience higher
levels of anxiety, depression, economic strain, and helplessness.
According to the prior studies, long-term psychotic illness can also
have negative impact on quality of life (QoL) in healthy siblings
he aim of our study was to assess QoL in siblings of patients
with first episode of psychosis and to examine effects of sibling-
related and illness-related variables onQoL. Study sample consisted
of first-episode psychosis patients (n = 20) and their healthy siblings
(n = 20). All subjects were administeredWorld Health Organisation
Quality of Life Questionnaire Scale Brief (WHOQOL-Brief). Dura-
tion of untreated psychosis, medication adherence (Hayward scale)
and severity of positive psychotic symptomatology (evaluated by
Positive and Negative Symptom Scale) were used as illness-related
variables, birth order served as a sibling–related variable. QoL has