European Psychiatry - Volume 41

25th European Congress of Psychiatry / European Psychiatry 41S (2017) S238–S302

S271

Conclusions

The association found between verbal fluency and

negative symptoms may be indicative of an overlap between those

constructs. Finally, verbal fluency might have a strong influence on

the clinical impression of negative symptoms, especially on alogia.

Fig. 1

Cognitive variables associated with psychopathological

symptoms.

.05;

.01.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2017.02.097

EW0484

Schizophrenia and pregnancy: The

tactics of management

S. Lukmonov

∗

, G. Ruzieva , I. Nazarova

Tashkent Medical Academy, psychiatry and narcology, Tashkent,

Uzbekistan

∗

Corresponding author.

Purpose

The study of literature data of the treatment of pregnant

women with schizophrenia and making recommendations on the

management of this category of patients.

Methods

Theoretical analysis of a number of scientific works of

foreign researchers, which studied questions of application of psy-

chotropic drugs in patients with schizophrenia during pregnancy.

Discussion

The important source of problems for patients with

schizophrenia is a protection against pregnancy. The number of

children born in mentally ill mothers has increased at least three

times. Hereditary factors in children born from two parents with

schizophrenia plays, an important role: approximately 46–68%

of these children may develop schizophrenia. In studies on psy-

chotic means, there were no increase in number of anatomical

anomalies or deviations in the development associated with this

treatment. Low doses do not have a deleterious effect on fetal body

weight, duration of pregnancy, fetal or neonatal mortality, as well

as the frequency of malformations and deformities. Neither oral nor

deposited anti-psychotic drugs are not associated with malforma-

tions and malformations of the fetus.

Conclusion

(1) The drugs should be administered at the lowest

effective dose for the shortest possible time and decrease in the

dose during the last days before the birth. (2) Pregnant women

with acute psychotic disorders are dangerous, both for herself and

for the child. (3) After the birth due to high risk of recurrence or

exacerbation of schizophrenia taking anti-psychotic drugs should

be in full dose.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2017.02.098

EW0485

Alteration of cerebral blood flow

measured with SPECT in patients with

first episode psychosis

P. Makari´c

1 ,

∗

, D. Boˇsnjak

, I. Kekin

, P. Jelacic

, M. Haupert

uran

, M. Sisek- ˇSprem

, D. Peruˇsi´c

, P. Breˇci´c

, R. Petrovi´c

M. Rojni´c Kuzman

University Psychiatric Hospital Vrapˇce, The Addictions Department,

Zagreb, Croatia

University Psychiatric Hospital Vrapˇce, First Psychosis Unit, Zagreb,

Croatia

Zagreb University Hospital Centre, Department of Psychiatry,

Zagreb, Croatia

University Psychiatric Hospital Vrapˇce, Department of Psychotic

Disorders, Zagreb, Croatia

University Psychiatric Hospital Vrapˇce, Department of

Psychogeriatrics, Zagreb, Croatia

University Psychiatric Hospital Vrapˇce, Department of Affective

Disorders, Zagreb, Croatia

Zagreb University Hospital Centre, Department of nuclear medicine,

Zagreb, Croatia

∗

Corresponding author.

Introduction

Single-photon emission computed tomography

(SPECT) is a valid method for measuring regional cerebral blood

flow (rCBF). Recent studies regarding rCBF in patients with first

episode psychosis (FEP) reported heterogeneous results, but were

limited with small sample size. Neuroimaging can help us in set-

ting the diagnosis of illness, as well as in following the progress and

finding more effective treatment for psychotic disorders.

Objectives

To compare, baseline alterations of the rCBF using

SPECT with psychopathological status in FEP during acute phase.

Aims

To investigate the changes of rCBF in patients with FEP

during acute phase.

Methods

We conducted a study on 40 drug – naïve patients with

FEP at acute phase of illness during their hospitalization at Zagreb

University hospital centre. The diagnosiswas confirmed using diag-

nostic and statistical manual of mental disorders, fifth edition. rCBF

was measured with SPECT and psychopathological status rated

with the Positive and Negative Syndrome Scale.

Results

Our findings showed moderate to severe parieto-

temporal perfusion deficits, mild to moderate parieto-fronto-

temporal perfusion deficits or borderline perfusion deficits in all

but one patient.

Conclusion

Our results showed alteration in rCBF at the beginning

of the illness that indicate a biological market of psychotic disorder.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2017.02.099

EW0486

Treatment adherence in psychosis: A

2 years follow-up of first-psychotic

episode patients

S. Malta Vacas

∗

, R. Carvalho , M.J. Heitor

Hospital Beatriz Ângelo, Psychiatry and Mental Health, Lisboa,

Portugal

∗

Corresponding author.

Introduction

Much research on psychosis has focused on early

detection and the development of effective interventions. However,

the effectiveness of any intervention depends on the willingness of

the patient to engage with an intervention in a sustained manner.

Disengagement from treatment by patients with serious mental

illness is a major concern of mental health services.

Objectives

This study aims to examine the prevalence of disen-

gagement in a longitudinal cohort of first episode psychosis (FEP)

patients.