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25th European Congress of Psychiatry / European Psychiatry 41S (2017) S8–S52


(FEDER). The Health Services of the Principado de Asturias, Spain,

donated part of the medication used in this study.

Symposium: Modifying outcomes of ADHD across

the lifespan


Continuity of ADHD across the lifespan

P. Asherson

Institite of Psychiatry Psychology and N, King’s College London,

London, United Kingdom


Formany years ADHDwas thought to be a childhood

onset disorder that has limited impact on adult psychopathology.

However, the symptoms and impairments that define ADHD often

affect the adult population, with similar responses to drugs such as

methylphenidate, dexamphetamine and atomoxetine to those seen

in children and adolescents. As a result, there has been a rapidly

increasing awareness of ADHD in adults and an emergence of new

clinical practice across the world. Despite this, treatment of adult

ADHD in Europe and many other regions of the world is not yet

common practice and diagnostic services are often unavailable or

restricted to a few specialist centres.


Herewe address some of the key conceptual issues sur-

rounding the continuity of ADHD across the lifespan, with a focus

relevant to practicing health care professionals working with adult



We conclude that ADHDshouldbe recognisedwithin

adult mental health in the sameway as other common adult mental

health disorders. Failure to recognise and treat ADHD will be detri-

mental to the well being of many patients seeking help for common

mental health problems.

Disclosure of interest

The author declares that he has no compet-

ing interest.


Non-Pharmacological treatment of

ADHD across the lifespan

A. Philipsen

University of Freiburg, Germany

Attention Deficit Hyperactivity Disorder (ADHD) is a serious risk

factor for co-occurring psychiatric disorders and negative psy-

chosocial consequences over the lifespan. Given this background,

there is a need for an effective treatment of ADHD patients.

In the lecture, evidence-based psychosocial interventions for ADHD

will be presented.

Disclosure of interest

Books and articles on ADHD.

Ad Boards, Phase-III Studies on ADHD in the last five years.

Symposium: Non-Invasive brain stimulation:

From mechanisms to applications


Does transcranial electrical

stimulation induce changes in

peripheral physiology?

S. Lehto

University of Helsinki, Department of Behavioural Sciences, Helsinki,


Transcranial electrical stimulation (tES) is a non-invasive brain

stimulation method that has evoked increasing interest during

the past years. The most common form of tES, transcranial direct

current stimulation (tDCS), is considered to modulate neuronal

resting potentials. For example, anodal stimulation over motor cor-

tex appears to lead to increased neuronal excitability under the

stimulation electrodes. However, some recent findings suggest that

the effects of tDCS extend beyond the cortical areas under the elec-

trodes, to deeper brain structures such as the midbrain. The brain

also actively regulates peripheral physiology. Thus, changes inbrain

activity following tES may lead to modulation of peripheral physi-

ology. For example, tDCS targeting primary motor cortex has been

observed to induce changes in peripheral glucose metabolism. Fur-

thermore, stimulation of dorsolateral prefrontal cortex has been

shown to lead to alterations in cortisol secretion and the activity

of the autonomic nervous system. Unpublished findings from our

group corroborate with the above observations. Nevertheless, the

evidence regarding peripheral effects of tES remains limited. Inves-

tigating such possible effects may be relevant especially from the

point of view of tES safety and potential therapeutic discoveries.

Disclosure of interest

The author has not supplied his declaration

of competing interest.


The effect of prefrontal transcranial

direct current stimulation on resting

state functional connectivity

D. Keeser

Ludwig-Maximilians-University, Department of Psychiatry and

Psychotherapy, Institute for Clinical Radiology, Munich, Germany

Transcranial direct current stimulation (tDCS) of the prefrontal

cortex (PFC) is currently investigated as therapeutic non-invasive

brain stimulation (NIBS) approach in major depressive (MDD) and

other neuropsychiatric disorders. In both conditions, different sub

regions of the PFC (e.g. the dorsolateral prefrontal cortex, the dor-

somedial prefrontal cortex and others) are critically involved in

their respective pathophysiology. Although the neurophysiological

properties of tDCS have been extensively investigated at the motor

cortex level, the action of PFC tDCS on resting state and functional

MRI connectivity of neural networks is largely unexplored. Beyond

motor cortex paradigms, we aim to establish a model for PFC

tDCS modulating functional connectivity in different conditions to

provide tailored tDCS protocols for clinical efficacy studies inmajor

psychiatric disorders such as MDD and schizophrenia. One major

obstacle in brain research is that patients represent themselves as

individuals not as groups. Recent research has shown that the indi-

vidual human brain functional MRI connectivity shows different

within-variability than the variability found between subjects. Sev-

eral neuroimaging methods may be useful to find a classifier that

can be reliable used to predict NIBS effects. These neuroimaging

methods include individual brain properties as well as the evalu-

ation of state-dependency. Anatomical targeted analyses of rTMS