European Psychiatry - Volume 41 - April 2017

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25th European Congress of Psychiatry / European Psychiatry 41S (2017) S8–S52 S37
associated with a higher probability to have a full recovery at three
years follow up.
Conclusions These results challenge a concept of recovery in EDs
exclusively based on weight restoration or behavioral changes. An
assessment including sexual functioning and core psychopathology
might identify the residual pathological conditions, and it is able to
provide information regarding the long term recovery process.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
S097
Oxytocin as a treatment enhancer in
anorexia nervosa
J. Russell ∗, S. Maguire , A. Kesby , I. McGregor , A. O’Dell ,
J. Treasure
1 Discipline of psychiatry university of Sydney Northside clinic,
department of psychology, Greenwich NSW, Australia
2 University of Sydney, department of psychology, Sydney, Australia
3 Discipline of psychiatry university of sydney northside clinic,
department of psychology, Sydney, Australia
4 Kings college London, psychological medicine- the eating disorders
research group, London, United Kingdom
∗ Corresponding author.
Introduction Nutritional rehabilitation in anorexia nervosa (AN)
is impeded by fear of food, eating and change leading to treat-
ment resistance. Oxytocin exerts prosocial effects on anxiolysis,
fear modulation, trust and brain plasticity.
Objective A placebo-controlled RCT examined the effects of self-
administered intranasal oxytocin (IN-OT) in AN patients.
Aim To ascertain whether single and repeated doses of IN-OT
enhance treatment in AN.
Methods Female AN patients self-administered twice daily 18IU
IN-OT (n = 21) or placebo (n = 21) for 4–6 weeks during hospital
treatment. Weight and BMI were measured at baseline and after
treatment. The Eating Disorders Examination (EDE) was the pri-
mary outcome measure. Cognitive rigidity was compared between
groups after four weeks repeated dosing. The effects of the first
and last doses of IN-OT versus placebo, on salivary cortisol before
a high-energy afternoon snack, were compared.
Results Weight gain was similar in IN-OT and placebo groups.
Only the EDE eating concern subscale score was significantly lower
after 4–6 weeks (mean 35 days) of IN-OT (p = 0.006). Anticipatory
levels of salivary cortisol fell from baseline after the initial dose
in contrast to the placebo group where levels increased. After four
weeks IN-OT, salivary cortisol was significantly lower (p = 0.023)
overall with little anticipatory increase compared to placebo. There
were no differences in anxiety scores. Cognitive rigidity was signif-
icantly lower in the IN-OT group (p= 0.043)
Conclusions Self-administered IN-OT might enhance nutritional
rehabilitation in AN by reducing eating concern and cognitive rigid-
ity. Lower salivary cortisol before a high-energy snack, suggests
reduction of fear rather than anxiety.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
Symposium: Role of psychiatry in dementia care
S098
Pychiatrists and legal issues in
dementia care
M.M. Carrasco
Instituto de investigaciones, Psiquiátricas, Spain
During more than half a century, Psychiatry has extensively
accepted a biomedical model studying mental disorders (including
schizophrenia, affective disorders and the large group of stress-
related disorders, including anxiety disorder. Thus, the classical
dichotomy between functional and organic psychiatric disorders
is obsolete and from a theoretical point of view there should be no
obstacle for Psychiatry to deal with the study of dementias from
gene to clinical levels using empirical methods, including neuro-
transmitters and scanning techniques. However, inmany European
countries, the dementias have been claimed as belonging primar-
ily to Neurology, leaving the role of psychiatrists to treat psychotic
symptoms and bizarre behavioral disturbances.
However, psychiatrists have a long tradition of detailed psy-
chopathological description and great skill in coping with themany
psychological, ethical and social problems that are such important
features of mental disorders and particularly the dementias, and
so, the specific skills of psychiatrists will certainly be warranted in
managing the many significant psychological and social problems
of the patient both within the family and in society. The discussion
must overcome the sterile debate between specialties to focus on
the skills needed to adequately address the needs of patients with
dementia and their caregivers.
Disclosure of interest The author has not supplied his declaration
of competing interest.
S099
Role of psychiatrists in memory clinics
F. Verhey
University of Maastricht, The Netherlands
Memory clinics (MCs) are multidisciplinary teams involved with
early diagnosis and treatment of people with dementia. In this pre-
sentation, we will discuss several trends of the role of psychiatrists
over the last twenty years, on the basis of five questionnaires that
were sent to MCs every 5 years in the Netherlands.
MCs have developed in Europe using a range of service models
but providing similar functions, which include assessment, infor-
mation, treatment monitoring, education, training and research.
MCs may vary among each other, and across countries. Psychia-
trists used to play a coordinating role in most MCs, but there is
now a tendency that MCs are more frequently led by other special-
ists, notably neurologists. In 1998 in the Netherlands, only a small
minority of the MCs had a structural cooperation with local service
providers, but 10 years later, most of themwere collaborating with
other regional care organizations. In most cases, the collaborating
partner was a community mental health team or a long-term care
facility.
Disclosure of interest The author has not supplied his declaration
of competing interest.