European Psychiatry - Volume 41 - April 2017

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S414 25th European Congress of Psychiatry / European Psychiatry 41S (2017) S405–S464
Methods We present a literature review of some scientific arti-
cles found on Pubmed search using “deep brain stimulation and
obsessive compulsive disorder/DBS and OCD”.
Results Clinical outcome of DBS for OCD shows robust effects in
many studies. It appears that most patients regain a normal quality
of life after DBS, reporting changes in perception, feeling stronger
and more confident, and doing things unreflectively. It seems that
DBS is a valid alternative to lesional ablative neurosurgery for
severe, therapy-refractory OCD patients, although with partially
discrepant results probably related to differences in anatomical
targeting and stimulation conditions.
Conclusions DBS seems to be a promising modality for the treat-
ment of some refractory psychiatric disorders such as OCD, but the
search for the best target still continues. Randomized studies with
larger samples are needed to establish the optimal targeting and
stimulation conditions.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV0029
Is there a difference in prevalence of
anxiety and depression symptoms
among patients with different stages
of hypertension?
A. Mermerelis ∗, S.M. Kyvelou , V. Akke , C. Papageorgiou ,
C. Stefanadis , A. Douzenis
1 2nd Psychiatric Clinic Athens University, Attikon Hospital, Athens,
Greece
2 1st Cardiology Clinic Athens University, Cardiology Clinic, Athens,
Greece
3 Epidemiology Department Galway university Hospital,
Epidemiology, Galway, Ireland
4 1st Psychiatric Clinic Athens University, Aiginition Hospital, Athens,
Greece
5 1st Cardiology Clinic Athens University, Hippokration Hospital,
Athens, Greece
∗ Corresponding author.
Introduction Whether anxiety and depression are associated
with hypertension and to what extent is not clear.
Aims The aim of the present study was to assess any differences
in the prevalence of anxiety and depression among different groups
of hypertensive patients.
Methods The study cohort comprised of 127 patients (75 male,
mean age 54 ±14) who underwent assessment of their blood
pressure levels andwere divided in four groups: group I (normoten-
sives, n = 34), group II (stage 1 HTN, n = 33), group III (stage 2 HTN,
n = 30) and group IV (stage 3 HTN, n = 30). The evaluation of anx-
iety disorder was made by means of Hospital Anxiety Depression
Scale (HADS), while the evaluation of depression was made with
the Beck Depression Inventory (BDI). Statistical analysis was done
with SPSS for windows. P-value was set at 0.05 for differences to
be considered significant.
Results Comparing the four groups of patients therewas a signifi-
cant difference both in BDI (8.6 ± 7.0 vs. 11.6 ±10.4 vs. 27.1 ± 5.8 vs.
32.4 ± 3.9, P < 0.0001) and HADS (10.2 ±7.2 vs. 9.7 ± 7.0 vs. 16 ±4.7
vs. 27 ± 5.1, P < 0.0001). We proceeded to comparison among the 4
groups and there was a significant rise in the BDI and HADS in three
of the four groups group II > group III > group IV, P < 0.0001.
Conclusion These data suggest that there is a clear burden of anx-
iety and depression as the levels of BP increase. This finding is of
important clinical significance as it could contribute to a differ-
ent approach of hypertensive patients. A larger cohort study could
enlightened the mechanisms involved.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV0030
Association of arterial stiffness
burden with anxiety and depression
in different stages of hypertension
A. Mermerelis ∗, S.M. Kyvelou , V. Akke , C. Papageorgiou ,
C. Stefanadis , A. Douzenis
1 2nd Psychiatry Clinic, Athens University, Attikon Hospital, Athens,
Greece
2 1st Cardiology Clinic, Athens University, Hippokration Hospital,
Athens, Greece
3 Epidemiology Department, Galway University, Galway, Ireland
4 1st Psychiatry Clinic, Athens University, Aiginition Hospital, Athens,
Greece
∗ Corresponding author.
Introduction There has been an attempt to associate anxiety and
depression with arterial stiffness. In the present study, we assessed
differences in arterial stiffness among 3 groups of hypertensive
patients compared to control normotensives as well as possible
association with anxiety and depression scoring system.
Methods The study cohort comprised of 127 patients (75 male,
mean age 54 ± 14) who underwent assessment of their blood
pressure levels andwere divided in four groups: group I (normoten-
sives, n = 34), group II (stage 1 HTN, n = 33), group III (stage 2 HTN,
n = 30) and group IV (stage 3 HTN, n = 30). The evaluation of anx-
iety disorder was made by means of Hospital Anxiety Depression
Scale (HADS), while the evaluation of depression was made with
the Beck Depression Inventory (BDI). Arterial stiffness evaluation
was done with Cardio-Ankle Vascular Index (CAVI). Statistical anal-
ysis was done with SPSS for windows. P-value was set at 0.05 for
differences to be considered significant.
Results Both CAVI R and CAVI L indices were significantly higher
as the severity of hypertensionprogressed (P < 0.001). BDI scorewas
significantly correlated with CAVIR (Pearson r = 0.53, P < 0.0001)
and CAVI L (Pearson r= 0.39, P < 0.0001). HADS score was also sig-
nificantly correlated with both CAVIR (Pearson r = 0.53, P < 0.0001)
and CAVIL (Pearson r = 0.43, P < 0.0001).
Conclusions There is a burden in the arterial stiffness of this pop-
ulation with the increase of the levels of BP which is not surprising.
However, the new finding is that there is a strong correlation with
arterial stiffness indices and both anxiety and depression scoring
system.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV0031
The relationship of social phobia and
personality characters in colleague
students
M. Mokhtaree ∗, P. Aghamohammad Hasani
Rafsanjan University of Medical Sciences, Moradi Hospital,
Rafsanjan, Iran
∗ Corresponding author.
Social anxiety disorder, pervasive and debilitating disorder with
a high rate that affects many aspects of human life. The aim of
the study was to assess the relation between social phobia and
personality traits of Rafsanjan University of medical sciences stu-
dents. By using Cochran formula and random stratified sampling,
284 person of Rafsanjan University of medical sciences students
selected. Participants responded to questions of the NEO Person-
ality and Social Phobia questionnaire. Data analyzed with Pearson
correlation coefficient, analysis of variance and regression. Among
the individuals, 11.6% had severe social phobia and 4.6% very
severe. The relationship between social phobia and neuroticism
was reversed and significant and other personality characters were
significantly. Neuroticism and openness predicted social phobia