European Psychiatry - Volume 41 - April 2017

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S438 25th European Congress of Psychiatry / European Psychiatry 41S (2017) S405–S464
EV0106
Low salivary secretory IgA levels
correlate with hyperreactivity in
children with autism
M.T. Sindelar ∗, N.E. Furland
1 Provincial Southwestern University, Faculty of Local and Regional
Development, Bahia Blanca, Argentina
2 CONICET-UNS, INIBIBB, Bahia Blanca, Argentina
∗ Corresponding author.
Introduction Autism is a neurodevelopmental disorder charac-
terized by deficits in communication and social skills as well
as stereotypical behaviors. There are multiple lines of evidence,
suggesting that the immune system is involved in autism. Since
secretory IgA (SIgA) is the predominant antibody isotype in saliva
and a marker of mucosal immunity, the aim of the study was to
assess if the severity of clinical and behavioral parameters of autis-
tic children was associated with low levels of sIgA in saliva.
Objectives To assess possible associations between salivary levels
of sIgA and the severity of behavioral outcomes related to autism.
In addition, were studied sIgA in saliva of children with autism and
the frequency of respiratory tract infections diagnosed in the first
3 years of life.
Methods Saliva samples were obtained from 3–10 years old
autistic children and age-matched typically developing Caucasian
children from Patagonia, Argentina.
Results Autistic children with reduced levels of salivary sIgA had
a higher incidence of respiratory diseases compared to controls.
The reduction in sIgA levels inversely correlated with the sever-
ity of the behavioral disorders. The patients with the most severe
impairment in autism-related behaviors had the lowest levels of
sIgA in the cohort studied.
Conclusions These findings suggest that sIgA could be an early
non-invasive indicator of the dysregulation of the immune sys-
tem in some children with autism. Clearly, the characterization of
immunological parameters has important implications for detec-
tion of subgroups of children with ASD, and should be considered
when designing therapeutic strategies to treat behavioral impair-
ments of ASD.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV0107
Clinical and social outcome of
children and adolescents presenting
in the emergency room for disruptive
behavior in Lyon and the Rhône-Alpes
region: A multidisciplinary approach
Y. Gansel , K. Behrouz , G. Sonia , E.A. Lamia , T. Mohamed ∗,
P. Dominique , B. Nadine , R. Bertrand
1 Hospices civils de Lyon, hôpital Femme–Mère-Enfant,
psychopathologie du développement, Bron, France
2 Hospices civils de Lyon, groupement hospitalier Est, centre
d’investigation clinique, Bron, France
3 Centre hospitalier Le Vinatier, pôle de pédopsychiatrie, Bron, France
4 Hospices civils de Lyon, Hôpital Femme–Mère-Enfant, service
d’accueil médical des urgences, Bron, France
5 Hospices civils de Lyon, centre hospitalier Lyon Sud, service de
biostatistique, Pierre-Bénite, France
6 Université Lumière Lyon 2, centre Max-Weber, Bron, France
∗ Corresponding author.
Over the last decade, the frequency of emergency room (ER) visits
for pediatric psychiatric disorders has increased in the most west-
ern countries. Although data available in France is scarce, a similar
trend was observed concerning violent or runaway youth. There
is no medical consensus on the status and care management of
disruptive behavior (DB) in children and adolescents in ER. Seclu-
sion and physical restraint are often requested to treat violence.
With a blur lawful framework for minors, such coercive measures
raise ethical issues while contradicting the idea of the patients’
autonomy and well-being. Moreover, consulting in the ER for such
situations could lead to an inappropriate use of the healthcare
system, a poor assessment of associated psychiatric disorders or
co-morbidities and an underestimation of suicide risk. Thus, the
ER visit for a disruptive child or adolescent is characterized by its
uncertainty. It represents a situation of heterogeneity in care man-
agement as well as a stake of social exclusion and of dangerous
behavior.
The study aims to:.
– analyze these uncertainties by presenting a multidisciplinary and
integrative research methodology through combining clinical evi-
dence and social sciences comprehension;
– to implement a cohort to describe children and adolescents
admitted to the ER for DB (aggressiveness, violence, fugue or theft),
their care management and their social and clinical outcome;
– to pool these clinical datawith an ethnographic fieldwork focused
on DB as a “trouble” experienced by various professionals in the ER.
We will focus our presentation on these methodological consider-
ations.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV0108
Child and adolescent service and
community mental health center:
HoNOS findings in a joint take in
charge model in Trieste
A. Bignotto , D. Celona , E. Pascolo Fabrici , D. Garino ∗
1 University of Trieste, Medicine and Surgery, Trieste, Italy
2 University of Trieste, Mental Health Department, Trieste, Italy
3 University of Udine, Dependency Department S.S.3, Trieste, Italy
∗ Corresponding author.
Introduction A collaboration between the Child and Adolescent
Unit 2 (Badof-2) and CommunityMental Health 2 (CMHC-2) started
several years ago in order to have a joint take in charge of under
25 people presenting needs to either one of the services. A major
focus has been put, in this period, on early psychotic onset.
Objectives The impact of schizophrenia and other psychotic dis-
orders ondaily life has been verywell studied in clinical populations
and in general ones, leaving some gaps on which are more heavily
involved in the resulting disability. In this study, we have used the
HoNOS scale, in the Italian validated version, in order to evaluate
the single items.
Methods We have enrolled all the under-30 people taken
in charge by the two aforementioned services in the period
2013–2016 with a ICD-10 F20–F29 diagnosis, dividing them in two
subgroups ( 13– 14 and 15– 16) in order to find if there was an
impact of the prolonged time of take in charge. A HoNOS evaluation
has been submitted to all the 21 people found.
Results HoNOS scores of the first subgroup are generally lower
than the ones of the second subgroup (median: 6 vs. 16.5). Self-
harmness, cognitive disorders and post-psychotic depression have
a heavier impact in daily life than the classic positive and negative
symptomatology. Focusing on psychosocial recovery programs,
this area has been partly marginally affected.
Conclusions The two subgroups show different HoNOS scores,
with lower ones in the 13– 14 group. More studies on general
population and covariates should be conducted.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.