European Psychiatry - Volume 41 - April 2017

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S524 25th European Congress of Psychiatry / European Psychiatry 41S (2017) S521–S582
sheesha smoking habits were considered as the main risk factors
associated with stress.
Conclusion A large number of factors were associated with expe-
riencing menopausal and psychosocial problems and which had
negative effects on the quality of life among Arabian women.
Depression, anxiety and stress should be considered as an impor-
tant risk factors for osteoporosis.
Disclosure of interest The author ha not supplied his/her declara-
tion of competing interest.
EV0369
Biomarkers of depressive disorders:
A multiplex analysis of blood serum
A.S. Boiko ∗, I.S. Losenkov , L.A. Levchuk , G.G. Simutkin ,
N.A. Bokhan , F.J. Bosker , B. Wilffert , A.J.M. Loonen ,
S.A. Ivanova
1 Mental Health Research Institute, Tomsk National Research Medical
Center, Laboratory of Molecular Genetics and Biochemistry, Tomsk,
Russia
2 Mental Health Research Institute, Tomsk National Research Medical
Center, Department of Clinical Psychiatry, Tomsk, Russia
3 University of Groningen, University Centre for Psychiatry,
Groningen, The Netherlands
4 University of Groningen, Department of Pharmacy, Groningen, The
Netherlands
∗ Corresponding author.
Depressive disorders are a great burden for individual patients
and society. Blood-based biomarkers are regarded as a feasible
option for investigation of depressive disorders. Several poten-
tial biomarkers for depression were selected. We studied the
following serum markers: cortisol, melatonin, brain-derived neu-
rotrophic factor (BDNF), prolactin, insulin-like growth factor 1
(IGF-1), -endorphin, orexin A. The patient sample consisted of 78
persons with depressive disorders. Patients were divided into two
groups: 46 patients with a first depressive episode and 32 patients
with recurrent depressive disorder. Control group consisted of
71 healthy individuals of corresponding age and sex. All markers
were measured in serum using MILLIPLEX® MAP panels (Merck,
Darmstadt, Germany) by analyzer MAGPIX (Luminex, USA). Sta-
tistical analyses were performed using SPSS software. Results
were expressed as median and quartile intervals [Q1–Q3]. There
was a significant increase of serum concentrations of cortisol
(663.69 [467.5–959.49] nmol/L, Р < 0.001) and melatonin (66.31
[33.6–132.59] pg/mL, P = 0.029) in patients compared with the con-
trol group (526.1 [367,24–654,7] nmol/L and 45.11 [27.47–73.47]
pg/mL). In addition, correlations were found between potential
biomarkers, clinical indicators and treatment response measured
by applying the Hamilton Depression rating scale and the Clinical
Global Impression rating scales. A significant correlation was found
between the concentration of prolactin and high response to phar-
macotherapy ( r = –0.267, P = 0.029). Identifying biomarkers that can
be used as diagnostics or predictors of treatment response in peo-
ple with depressive disorders will be an important step towards
being able to provide personalized treatment.
Disclosure of interest The work is supported by the project of
Russian Foundation of Basic Research N o 14-04-01157a.
EV0370
In patients with major depressive
disorders, depression, stress axis
activity and problem solving skills as
a proxy of executive functions are
unrelated
S. Brand ∗ Hatzinger . Hemmeter
D. Sadeghi Bahmani olsboer-Trachsler
1 Psychiatric University Hospital, Center for Affective- Stress and
Sleep Disorders, Basel, Switzerland
2 Department of Adult Psychiatry, Psychiatric Services Solothurn,
Solothurn, Switzerland
3 Psychiatric Service St. Gallen, Adult Psychiatry, St. Gallen,
Switzerland
∗ Corresponding author.
Introduction Major depressive disorders (MDD) are among the
most prevalent psychiatric disorders worldwide. While there is
abundant literature showing that an increased cortisol secretion,
understood as a proxy of the deteriorated hypothalamus-
pituitary-adrenocortical axis activity (HPA AA), and poor cognitive
performance are tightly related, less is known as regards to the HPA
AA and higher cognitive information processes such as problem
solving.
Aims Investigating the association between cortisol secretion
and problem solving performance among patients with MDD.
Methods Fifteen inpatients with MDD (HDRS > 24; mean age:
59 years; 80% females) underwent a pharmacologic HPA AA chal-
lenge both at baseline and six weeks later to assess the cortisol
secretion. They were treated with standard antidepressants at
therapeutic dosages. Further, they learned how to solve the Tower-
of-Hanoi problem-solving task (ToH-PS-T) and how to apply the
problem solving strategy to other tasks (transfer). Testing occurred
both at baseline and six weeks later. Outcome variables were
symptoms of depression, cortisol secretion and the performance
to transfer the acquired ToH-PS-T.
Results Both symptoms of depression and cortisol secretion
decreased over time, and transfer performance increased over
time. Neither at baseline nor six weeks later, symptoms of depres-
sion, transfer performance and cortisol secretion were statistically
related.
Conclusions The pattern of results suggests that cortisol secretion
as a proxy of physiological stress regulation, symptoms of depres-
sion, and higher order cognitive performances seem unrelated.
Given that cognitive information processing performance substan-
tively increased regardless from depression and cortisol secretion,
problem-solving skills need to be focused separately.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV0371
Poststroke depression
D. Brigadeiro ∗ unes , T. Ventura Gil , P. Costa
Hospital Sousa Martins, ULS Guarda EPE, Departamento de
Psiquiatria e Saúde Mental, Guarda, Portugal
∗ Corresponding author.
Psychiatric symptoms are the complications most often ignored in
patients who suffered a stroke. Depression is the most common
psychiatric complication in post-stroke patients with a prevalence
of about 20–50% in the first year and with a peak in first six
months after the stroke. Depression in turn, constitutes itself a fac-
tor of cerebrovascular risk. Despite its high prevalence this disorder
remains under diagnosed and under treated. One explanation for
this fact is that depressive symptoms are often misinterpreted as
consequences of stroke itself. This reality is even more striking in
patients with aphasia. Poststroke depression (PSD) results from the
interaction between biological, as the location of the stroke, social
and psychological factors. The presence of this disorder is asso-
ciated with deleterious consequences for rehabilitation process.
These patients suffer more often from attention deficits, cognitive
difficulties, lower response to rehabilitation programs, poor quality
of life and increased mortality.