European Psychiatry - Volume 41 - April 2017

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S526 25th European Congress of Psychiatry / European Psychiatry 41S (2017) S521–S582
– sociodemographic variables: positive family history of alcohol
abuse disorder in first-degree relative (increased antidepressant
response and fewer depressive symptoms for up to 4weeks post-
infusions), higher BMI (improvement in depression severity at
230minutes and one day post-infusion), negative history of suicide
attempt (greater improvement at day 7);
– infusion-associated events: greater dissociation during infusion
(better antidepressant response at 230minutes and oneweek post-
infusion); rapid response to first infusion (sustained response to
subsequent infusions in one-third responders for up to 83 days);
– symptomatology: anxious depression (fewer depression symp-
toms at day one up to 25 associated with longer time to relapse);
neurocognitive performance (lower attention) predicts change in
severity of depressive symptoms over six infusions.
Conclusions Findings suggest that specific clinical characteris-
tics are predictors of ketamine response in TRD. Future studies
confirming reliable predictors will assist clinicians to implement
efficacious and individualized treatment for TRD patients.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV0375
Major depressive disorder:
Recurrence risk factors
F. Ellouze ∗, W. Bouali , I. Marrag , A. Chaabouni , R. Ben Soussia ,
M. Nasr
CHU Tahar Sfar, Psychiatry, Mahdia, Tunisia
∗ Corresponding author.
Introduction Despite the frequency and the severity of depressive
episodes, the major depressive disorder (MDD) is today inade-
quately diagnosed and treated, and the risk factors for its recurrence
are not well elaborated. The objectives of this study were to
describe the sociodemographic, clinical evolutionary and therapeu-
tic features of this disorder and to identify the factors involved in
the risk of its recurrence.
Methods This is a retrospective, descriptive and analytical study,
involving 150 patients with MDD, isolated episode or recurrent
major depressive disorder (RMDD) with a follow-up for at least two
years. Data collection was performed using two pre-established
questionnaires for the MDD isolated episode and for the RMDD
respectively with 51 and 92 items. A study of the recurrence period
was performed by Kaplan–Meier method. The Cox-test was used
to determine the survival curves and to look for the risk factors
significantly associated with MDD recurrence.
Results A total of 150 patients was gathered, predominantly
female, married and from urban origin. The average age at the
beginning of the disorder was 35 years. The recurrence period was
109months and the factors associated with recurrence were the
early age of onset of the disorder, family history of mood disorders,
the severity of MDE index, residual symptoms and discontinuation
of treatment.
Conclusion The study of factors involved in MDD recurrence is of
a particular importance since it allows not only to know the group
of patients at risk but also to improve their therapeutic care.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV0376
Prevalence and risk factors of
postpartum depression among
preterm infant mothers
S. Ellouze , J. Aloulou , A. Ben Thabet , N. Halouani ∗,
A. Gargouri , O. Amami
1 Hedi Chaker University Hospital, Psychiatry “B” Department, Sfax,
Tunisia
2 Hedi Chaker University Hospital, Neonatology Department, Sfax,
Tunisia
∗ Corresponding author.
Introduction The birth of a preterm infant evokes consider-
able psychological distress in mothers and is associated with an
increased risk for postpartum depression.
Objectives The aim of this study was to assess the prevalence of
postnatal depression among preterm infantmothers and to identify
highlighting associated factors.
Methods We conducted a cross-sectional, descriptive and ana-
lytical study, including 97 mothers of premature infants who
presented to the outpatient unit of neonatology at the UH Hedi
Chaker of Sfax in Tunisia. For each mother, we collected sociode-
mographic and obstetric data. We used the Edinburgh Postnatal
Depression Scale (EPDS) for screening postpartum depression.
Results Average age of mothers was 30.2 years. Average gesta-
tional age was 32.82weeks. Almost all the mothers were married
(99%), had a satisfactory couple relationship (93.7%), almost two
thirds were multiparous (64.9%), and 77.3% gave birth by cae-
sarean section. Prematurity was unexpected by 56.7% of women.
Regarding newborns, digestive problems were noted in 25.8% of
cases and sleepdisturbances in20.6%of them. Prevalence of depres-
sion in the population studied was 39.2%. It was significantly
associated with unexpected prematurity (P < 0.001), impaired cou-
ple relationship (P = 0.001), digestive problems (P = 0.013) and sleep
disturbances ( P = 0.002).
Conclusion Mothers of preterm infants seem to be particularly
vulnerable to postpartum depression. Systematic screening for
depressive symptoms in this obstetric population can help to have
an optimal psychological outcomes for mothers and infants during
a crucial period of development of mother–infant coregulation.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV0377
Childhood trauma: A factor for
increased risk of major depression in
psoriatic patients
M. Erfanian
Maastricht University, Faculty of Psychology and Neuroscience,
Maastricht, The Netherlands
A history of childhood maltreatment (CM) is an important deter-
minant for understanding the development of psychiatric and
physical disorders. CM is associated with sensitization of cen-
tral nervous system (CNS) that leads to dysregulation of the
hypothalamic-pituitary-adrenal (HPA) axis arly life stress is a
well-known contributor tomajor depression he dysregulation
of HPA axis and sympathetic nervous system activity also impact
skin. Epidermis shows a high vulnerability to such psychological
stressors resulting to increase risk for psoriasis The current
study investigates the association between childhood trauma and
major depression, childhood trauma and psoriasis, and also severity
of major depression in female and male patients with psoria-
sis. Sixty-four psoriatic patients (female = 34, mean age = 46.87)
were evaluated with the Childhood Trauma Questionnaire (CTQ)
for the history of CM and with the MINI International Neuropsy-
chiatric Interview for the diagnosis of major depression. CM was
associated with major depression, indexed by a higher CTQ in
emotional ( 2(3) = 26.002, P < .0005) and physical abuse scores
( 2(3) = 23.764, P < .0005). CM limited to sexual abuse was asso-
ciated with higher severity of psoriasis ( 2(3) = 9.81, P < .02). There
was no indication of a difference betweenmen andwomen in sever-
ity of major depression (U = 444, P = .304). Our findings highlight
the importance of recognizing psychiatric comorbidity, in particu-