European Psychiatry - Volume 41 - April 2017

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S130 25th European Congress of Psychiatry / European Psychiatry 41S (2017) S106–S169
have a physical nature of infectious diseases, to burn regularly or
develop a mental disorder in adultery more than those not exposed
to bullying, 11 times more likely to develop anxiety disorder but
especially obsessive-compulsive disorder.
Some experts think that bullying results in a kind of “toxic stress”
that affects children’s physiological responses, possibly explaining
why some victims of bullying go on to develop health problems.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0074
Growth and sexual maturation in a
2-year, open-label clinical study of
lisdexamfetamine dimesylate in
children and adolescents with ADHD
I. Hernández Otero ∗, T. Banaschewski , M. Johnson , P. Nagy ,
C.A. Soutullo , A. Zuddas , B. Yan , D.R. Coghill
1 Hospital Virgen de la Victoria, Unit of Child and Adolescent Mental
Health USMIJ, Malaga, Spain
2 Central Institute of Mental Health, Medical Faculty Mannheim,
University of Heidelberg, Department of Child and Adolescent
Psychiatry and Psychotherapy, Mannheim, Germany
3 Gillberg Neuropsychiatry Centre, Sahlgrenska Academy,
Gothenburg University, Gothenburg, Sweden
4 Vadaskert Child and Adolescent Psychiatry Hospital and Outpatient
Clinic, Vadaskert Child and Adolescent Psychiatry Hospital and
Outpatient Clinic, Budapest, Hungary
5 University of Navarra Clinic, Child and Adolescent Psychiatry Unit,
Department of Psychiatry and Medical Psychology, Pamplona, Spain
6 University of Cagliari, Department of Biomedical Science, Child and
Adolescent Neuropsychiatric Unit, Cagliari, Italy
7 Shire, Lexington, MA, USA
8 University of Dundee, Division of Neuroscience, Dundee, United
Kingdom
∗ Corresponding author.
Introduction Individuals with attention-deficit/hyperactivity
disorder (ADHD) may require long-term medication.
Objectives To measure growth and sexual maturation of children
and adolescents with ADHD receiving lisdexamfetamine dimesy-
late (LDX) in a 2-year trial (SPD489-404).
Aims To investigate the impact of long-term LDX treatment on
growth and maturation.
Methods Participants (6–17 years) received dose-optimized,
open-label LDX (30–70 mg/day) for 104 weeks. Weight, height and
BMI z-scores were derived using the Centers for Disease Control
and Prevention norms exual maturation was assessed using
the Tanner scale (participant-rated as closest to their stage of devel-
opment based on standardized drawings).
Results Of 314 enrolled participants, 191 (60.8%) completed the
study. Mean z-scores at baseline and last on-treatment assessment
(LOTA) were 0.53 (standard deviation, 0.963) and 0.02 (1.032) for
weight, 0.61 (1.124) and 0.37 (1.131) for height, and 0.32 (0.935)
and–0.27 (1.052) for BMI. In general, z-scores shifted lower over
the first 36 weeks and then stabilized. At LOTA, most participants
remained at their baseline Tanner stage or shifted higher, based
on development of hair (males, 95.5%; females, 92.1%) or geni-
talia/breasts (males, 94.7%; females, 98.4%).
Conclusions Consistent with previous studies of stimulants used
to treat ADHD -scores for weight, height and BMI decreased,
mostly in the first year, then stabilized. No clinically concerning
trends of LDX treatment on sexual maturation or the onset of
puberty were observed.
Disclosure of interest Study funded by Shire Development LLC.
Dr Isabel Hernández Otero (Alicia Koplowitz Foundation, Eli Lilly,
Forest, Janssen-Cilag, Junta de Andalucia, Roche, Shire, Shire
Pharmaceuticals Iberica S.L., and Sunovion).
References
[1] Kuczmarski RJ, et al. Vital Health Stat 2002;11(246):1–190.
[2] Faraone SV, et al. J Am Acad Child Adolesc Psychiatry
2010;49:24–32.
EW0075
The effect of cognition enhancement
program using toy-robot for children
M.S. Shin ∗, H.J. Jeon , J.R. Park , J. Lee , H.W. Shin
1 Seoul National University College of Medicine, Department of
Psychiatry, Seoul, Republic of Korea
2 Seoul National University Children’s Hospital, Department of Child
and Adolescent Psychiatry, Seoul, Republic of Korea
∗ Corresponding author.
Objectives The purpose of this study was to verify the effect of
Cognition Enhancement Program(CEP) using toy-robot for children
aged 5–10 years. We thought that CEP using toy-robot might be
a more kids-friendly method for improving cognitive ability than
traditional programs. The enhancement of cognitive functions such
as attention, response inhibition, memory, and working memory
after the cognition training were the focus of the study.
Methods One hundred and twenty children aged 5 to 10 were
ramdomly assigned to 3 groups: (1) experimental group receiving
CEP training using toy-robot, (2) control group receiving previ-
ously developed internet-based cognitive training, (3) waiting list.
The children of experiment and control groups received individ-
ual 8 training sessions. The effect of the program was measured
with Smart Toyweb’s cognitive assessment tools we had developed
(smart device based assessment) as well as traditional neuropsy-
chological tests throughout 3 times (pre-training, post-training,
and 1-month follow-up).
Results The training is inprogress since it started inOctober 2016.
We observed some of children on the CEP training tend to show
improvement of cognitive function. The final assessment is planned
for February 2017.
Conclusions The CEP using toy-robot could be very promising and
useful in that it is a non-invasive and non-pharmacological treat-
ment for children with attention or memory problem in home and
clinical settings.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0076
Treated versus untreated mental
health problems in adolescents: A
six-year comparison of emotional and
behavioral problem trajectories
F. Jörg ∗, D. Raven , E. Visser , R. Schoevers , T. Oldehinkel
1 University Medical Center Groningen UMCG, ICPE, Groningen, The
Netherlands
2 University Medical Center Groningen UMCG, UCP, Groningen, The
Netherlands
∗ Corresponding author.
Introduction Multidisciplinary guidelines in adolescent mental
health care are based on RCTs, while treatment efficacy can be dif-
ferent from effectiveness seen in ‘the real world’. Studies in the
real world conducted so far suggest that treatment has a negligi-
ble effect on follow-up symptomatology. However, these studies
did not incorporate the pre-treatment trajectory of symptoms nor
investigated a dose-response relationship.
Objectives To test whether future treatment users and non-users
differed in emotional and behavioural problem scores, whether
specialist mental health treatment (SMHT) was effective in reduc-