European Psychiatry - Volume 41 - April 2017

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25th European Congress of Psychiatry / European Psychiatry 41S (2017) S106–S169 S133
Results After brief intervention the 29.3% of the smoking patients
change in their motivational stage. The results of the multivari-
ate analysis showed three factors in relation with dificultar the
progression of the evolution of motivation to change. The high
punctuation in Hamilton anxiety scale (OR = 0.53; IC95%, P = 0.002),
the high puntuation in the Fageström scale (OR = 0.56, IC95%,
P = 0.01), and have high autoperception of the capacity of change
(OR = 0.52; IC95%, P = 0.002).
Conclusions The anxiety (measure with Hamilton anxiety scale)
plus factors in relation with smoking, like the puntuation in Fage-
strom scale and the autoperception of the capacity of change
decrease the possibilities to change.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0083
Psychiatric vulnerability in adults
with intellectual disability and
autism: A literature review
S. Coli ∗, D. Scuticchio , M. Bertelli
Fondazione San Sebastiano, CREA, Firenze, Italy
∗ Corresponding author.
Introduction Adults with Intellectual disability (ID) and Autism
Spectrum Disorder (ASD) are more vulnerable to mental health
problems than the general population.
Objectives/aims This study investigates presence and rate of
psychiatric disorders in comparison with ID or ASD alone, and
appropriateness of assessment and diagnostic procedures or tools.
Methods A systematic mapping of the literature was carried
out on the basis of the above mentioned issues. The search was
conducted using PubMed and ScienceDirect, according to the fol-
lowing keywords: psychiatric comorbidity, psychiatric disorders,
autism, ASD, intellectual disability, mental health problems, adults,
assessment tools, diagnosis. Twenty-eight papers were selected for
pertinence to mapping issues among more than 500.
Results Many studies show that ASD is an important vulnerabil-
ity factor for psychiatric co-morbidity and for challenging behaviors
(CBs) in adults with ID. Highest rates were reported for psychotic,
mood, anxiety, and obsessive-compulsive disorders. Few studies
show that the difference between adults with ID plus ASD and
adults with only ID are not statistically significant, but for the pres-
ence of CBs in those with ID plus ASD. The disagreement of results
is based on a variety of factors such as diagnostic over-shadowing,
scarcity of specific assessment tools, consideration of the introspec-
tive and communication difficulties, incompleteness of medical
records, and low reliability of information sources.
Conclusions Although low studies concordance, the literature
mapping suggests the presence of ASD in ID to be associated with
higher rates of psychopathology. Since the relevant implications for
prevention and clinical management, further research with high-
level evidence is hoped.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0084
The influences of antipsychotics
therapy at cognitive impairments in
schizophrenia spectrum disorders
J. Dedovic ∗, A. Tomcuk , T. Mijatovic-Papic , N. Matkovic
1 Special Psychiatric Hospital, Forensic Psychiatric Unit, Kotor,
Montenegro
2 Special Psychiatric Hospital, Mental Health Promotion Centre,
Kotor, Montenegro
3 Special Psychiatric Hospital, Chronic Female Ward, Kotor,
Montenegro
4 Special Psychiatric Hospital, Addiction Ward, Kotor, Montenegro
∗ Corresponding author.
Significant degree of cognitive impairment represents one of
the basic cornerstones among clinical manifestations of the
schizophrenia spectrumdisorders and accordingly to some authors
it is present in up to 75% patients with these syndromes. The aim of
this study was to examine degree of cognitive impairment, firstly
among patients on first generation antipsychotics therapy (FGA)
compared to the patients on second generation antipsychotics ther-
apy (SGA), and secondly to compare both groups of patients with
healthy controls.
Material and methods Prospective, parallel research was con-
ducted, in which the sample of patients and employees of
Specialized Psychiatric Hospital Kotor was tested with Montreal
Cognition Scale (MoCA). There were 66 participants in the samples
and they were divided on four subgroups: (1) patients with FGA;
(2) patients with SGA; (3) patients with combined FGA and SGA;
(4) Healthy controls.
Results All groups of patients had statistically significantly lower
mean MoCA scores in the comparison with healthy controls. The
fact that among 83.7% of patients was diagnosed significant degree
of cognitive decline (MoCA score bellow 26) strongly speaks in
favour of high sensitivity of MoCA test in detection of cognitive
impairment among patients with schizophrenia spectrum psy-
chotic disorders. In addition, the group of patients with FGA also
had statistically significantly lower mean MoCA score compared to
patients with SGA.
Discussion The mechanisms of explanation of these results can
be additionally enlightened with further studies on larger sam-
ples of patients, which would investigate the correlation between
extrapyramidal symptomatology, anticholinergic therapy and cog-
nitive deficit.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0085
Subtypes of psychosis among
difficult-to-treat patients – A cluster
analytical replication study among
chronically psychotic,
institutionalized dual diagnosis
patients
R. Dost-Otter ∗ immerman Van Veen Diekman
1 GGZ Drenthe, FACT Assen, Meppel, The Netherlands
2 GGZ Drenthe, Location Assen, Assen, The Netherlands
3 GGZ Drenthe, Duurzaam Verblijf, Meppel, The Netherlands
∗ Corresponding author.
Background Research is lacking on possible subtypes of psychosis
in difficult-to-treat patients that require long-term institutional-
isation due to a combination of psychosis, substance abuse and
problem behaviours after multiple failed treatments.
Aim The aim of this study is to increase our knowledge of this
group of patients in order to apply more targeted interventions.
Objective To identify subtypes of psychosis among this group by
cluster analysis and compare these subtypes on different clinical
variables.
Methods PANSS data was acquired for 117 patients. Separate
clusters were identified by using Ward’s method of hierarchical
cluster analysis, replicating Dolffus et al., 1996 ho used this
method in a cohort of schizophrenia patients. Subtypes of psy-
chosis were identified using PANSS items. Clusters were compared
on several clinical variables, f.e. course of admission.