European Psychiatry - Volume 41 - April 2017

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S200 25th European Congress of Psychiatry / European Psychiatry 41S (2017) S170–S237
of additional use of the clarifying designation “synthetic cannabi-
noids/spice” at reference of patients using synthetic cannabinoids
to the section of ICD-10 F12 “Mental and behavioural disorders due
to use of cannabinoids” the agenda of clinicians.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0277
Adverse childhood experiences,
personality disorders and addiction:
Which relationship?
F. Cerrato ∗, G. Aluisio , P. Casadio , G. Di Girolamo ,
S. Valente , D. De Ronchi , A.R. Atti
1 Psychiatry, Department of Biomedical and Neuromotor Sciences-
Psychiatry, Bologna, Italy
2 AUSL Romagna, Pathological Addiction Department, Faenza, Italy
∗ Corresponding author.
Introduction Stressful or traumatic events occurred during child-
hood do have a role in the genesis of personality disorders. Less is
known about this remarkable association in people with addictive
behaviors.
Aims This study aims to disentangle the relationship between
childhood adverse experiences, personality disorders (PDs) and
substance use disorders (SUDs).
Methods A cross-sectional naturalistic study of 320 consecutive
SUDs outpatients attending an Italian addiction service. Partici-
pants were clinically evaluated by a semi-structured interview, the
SCID-II (StructuredClinical Interviewfor DSM-IVAxis II PD), and the
CECA-Q (Childhood Experience of Care and Abuse-questionnaire).
Multivariate logistic regression analyses were used to estimate
odds ratio (OR) and 95% confidence intervals (95% CI)
Results The prevalence rate of PDs in our sample of patients is
62.2%. PDswere associatedwith a history of physical punishment in
childhood (OR = 1.82; CI 95%: 1.05–3.16; P= 0.034). Being exposed
to three adverse events increases the risk of Cluster B PD (OR = 5.92;
CI 95%: 2.21–15.92; P < 0.001). Heroin addiction increases the risk
of Cluster B PD, both as previous (OR = 2.93; CI 95%: 1.49–5.75;
P = 0.003) or current (OR = 4.34; IC 95%: 1.97–11.8; P= 0.004) con-
sumption. Childhood institutionalization increases the probability
of cluster B PD (OR: 2.15; CI 95%: 1.02–4.54; P = 0.041). Whereas
being employed reduces the probability of both PDs and SUDs
(OR = 0.54; CI 95%: 0.31–0.93; P = 0.027).
Conclusions PDs occurred in 62% of patients and were related
to adverse childhood experiences and SUDs having detrimen-
tal effects on both social and occupational functioning. Being
employed could be a protective factor on the development of PDs.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0278
The prevalence and correlates of
depression awareness in patients with
alcohol use disorder
C. Charnsil ∗ roonrattanapong
ChiangMai University, Psychiatry, Chiang Mai, Thailand
∗ Corresponding author.
Introduction Alcoholic use disorder is a big problem in every
country. It is the leading factor causing high disability-adjusted life
year (DALYs). The National Institute of Mental Health Epidemiol-
ogy Cathchment Area found that 37% of people with alcoholic use
disorder had comorbid along with psychiatric disorder especially
depression. In order to successfully treat patientswith alcoholic use
disorder, we have to treat their comorbidity along as well.
Aim To examine the prevalence and correlation of depression
awareness in patients with alcoholic use disorder.
Methods Inpatients and outpatients who were diagnosed with
alcoholic use disorder and alcohol dependence were invited to
participate in this research. Subjects who had any history of
depressive disorder treatment before were excluded. The aware-
ness of depression was determined by the Illness Perception
Questionnaire-Revised, IPQ-R. Depressive disorder was deter-
mined by the Thai version of the nine-item Patient Health
Questionnaire (PHQ-9).
Results Ninety subjects with alcoholic use disorder agreed to
join this research. Twenty-nine of the 90 (32.2%) had depression
due to the PHQ-9 scale. Twenty-three were aware that they had
depression and that was related to alcohol use. Using the logistic
regression analysis, there were no significant factors related to this
awareness.
Conclusion There is high prevalence of depression in patients
with alcoholic use disorder and most of them have awareness did
not receive treatment for depression.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0279
Metacognitive awareness in cocaine
addiction (MACA): Rationale and
feasibility of an integrated
intervention program
S. Cheli ∗, F. Velicogna , P. Fioravanti , A. Simeone , C. Enzo ,
S. Di Natale , V. Cavalletti , M. Taddeo
1 University of Florence, School of Human Health Sciences, Florence,
Italy
2 Tages Charity, Center for Psychology and Health, Florence, Italy
3 Centro di Solidarietà di Firenze, Progetto Conoscenza, Florence, Italy
4 Tages Charity, Center for Psychology and Health, Padua, Italy
∗ Corresponding author.
Introduction Systematic reviews and meta-analyses report low-
quality evidence to suggest a significant differential effectiveness
between standard psychosocial interventions in reducing sub-
stance consumption. They highlight the presence of several types
of treatments that usually integrate different approaches in a mul-
timodal manner. CBT-based interventions seem to be the most
effective ones in terms of dropouts and relapse prevention, par-
ticularly in cocaine addiction.
Objectives We discuss recent advances in experimental and clin-
ical studies on cocaine addiction. We especially try to integrate
emerging cognitive neuroscience evidences and results of the
meta-analyses of the effectiveness of psychosocial interventions.
Aims The primary aim of this study is to explore the feasibility
of a new multimodal intervention for cocaine addiction, namely
MACA (Metacognitve Awareness in Cocaine Addiction). Secondary
aims are to discuss: (i) rationale of integrating different approaches;
(ii) preliminary results of a previous pilot-study; (iii) feasibility
of present study using the RE-AIM (reach, effectiveness, adoption,
implementation, and maintenance) framework.
Methods We describe and evaluate our model that comprises:
– an individual short intervention based on dilemma-focused ther-
apy;
– a psycho-educational group based on standard CBT treatments;
– a relapse-prevention group based on mindfulness protocols for
addiction;
– a follow-up online self-administered course and automatic per-
sonalized feedback.
Results Existing literature seems to support the need for new
integrated programs. RE-AIM feasibility analysis shows promising
results in integrating the proposed approaches in terms of symp-
toms reduction, relapse prevention and cost-benefit ratio.