European Psychiatry - Volume 41 - April 2017

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25th European Congress of Psychiatry / European Psychiatry 41S (2017) S170–S237 S201
Conclusions Preliminary evidence supports potential for the
MACAprogram in treating cocaine addiction. The research design of
await-list controlled trial with pre- and post-treatment assessment
is discussed.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0280
Evaluation of the use of psychoactive
substances among patients admitted
to a cardiology intensive care unit:
Prevalence and prevention
C. Chevallier ∗, A. Batisse , B. Merat , J.G. Dillinger ,
E. Bourgogne , H. Gourlain , M. Marillier , P. Henry ,
O. Laprevote , D. Samira
1 GH Lariboisière-Fernand Widal, CEIP, Paris, France
2 GH Lariboisière-Fernand Widal, Intensive Care Unit of Cardiology,
Paris, France
3 GH Lariboisière-Fernand Widal, Toxicology laboratory, Paris, France
∗ Corresponding author.
Introduction Addiction to psychoactive substances (PAS) can lead
to cardiovascular complications. Cardiotoxicity of drugs is known
but it is rarely documented by toxicology.
Objectives We conducted a prevalence study on PAS use among
patients with cardiac symptoms, with an analysis of diagnosis and
a description of PAS user’s characteristics.
Aims To improve the therapeutic management in addictology for
cardiac patients.
Methods Prospective observational study performed during
3months. Patients admitted in cardiology had to complete a hetero-
questionnaire about his PAS consumption and a qualitative toxico-
logical research in urine and/or blood (immunochemical/GC–MS
detection).
Results One hundred and sixty-one patients were included: 86%
men, aged 24–68 years Results show a high level of PAS
use in our population: 8.7%. A significant PAS use is observed among
patients aged 40–70 years, with a prevalence of 22% for the 40–49,
15% for the 50–59 and 7% for the 60–69. PAS detected were mainly
cannabis and cocaine. Clinical diagnoses of patients positive to PAS
were acute coronary syndromes and severe cardiac arrhythmias.
Conclusions In patients admitted in cardiology, toxicological
screening is rarely done. Our study shows a significant PAS use
among patients aged 40–70 years. According to data of the French
Health Barometer, there is regular use of cannabis and cocaine
at respectively 3% and 1.1% among people aged 18–64. These
results invite us to achieve a more systematic identification of
PAS use among patients with cardiovascular disorders and to
optimize the therapeutic management by a systematic orientation
in addictology.
Table 1 Patients characteristics.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0281
Role of co-occurring alcohol and
substances abuse on QTc interval
prolongation among psychiatric
patients: A cross-sectional national
survey
M. Corbo ∗, T. Acciavatti , F. Fiori , R. Santacroce , A. Aguglia ,
F. Bartoli , S. Calò , M. Ribolsi , Y. Barone , F. Pinna , M. Stilo ,
P. Staffa , M. Caroleo , S. Ruberto , M.S. Signorelli , F. Suraniti ,
D. Quattrone , C. Reggianini , E. Carra , E. Gazzoletti ,
O. Campese , M. Castellazzi , G. Ostuzzi , I. Bighelli ,
M. Nosè , C. Barbui , G. Martinotti
1 University “G. D’ Annunzio” Chieti, Neuroscienze, Imaging e Scienze
Cliniche, Chieti, Italy
2 University of Turin, Department of Neuroscience Rita Levi
Montalcini, Turin, Italy
3 University of Milano Bicocca, Department of Surgery and
Interdisciplinary Medicine, Milan, Italy
4 Azienda Sanitaria Locale Lecce, Dipartimento di Salute Mentale,
Lecce, Italy
5 Università degli Studi di Roma Tor Vergata, Clinica Psichiatrica,
Dipartimento di Medicina dei Sistemi, Roma, Italy
6 University of Cagliari, Department of Public Health, Clinical and
Molecular Medicine, Unit of Psychiatry, Cagliari, Italy
7 Università degli Studi Magna Graecia, Unità Operativa Psichiatra,
Dipartimento di Scienze della Salute, Catanzaro, Italy
8 Università degli Studi di Catania, Clinica Psichiatrica, Dipartimento
di Medicina Clinica e Sperimentale, Catania, Italy
9 King’s College, Institute of Psychiatry, Psychology and Neurosc,
Londonu, United Kingdom
10 Università degli studi di Modena e Reggio Emilia, Dipartimento di
medicina diagnostica, clinica e di sanità pubblica, Modena, Italy
11 Università degli studi di Modena e Reggio Emilia, Dipartimento di
medicina diagnostica, clinica e di sanità pubbli, Modena, Italy
12 University of Verona, WHO Collaborating Centre for Research and
Training in Mental Health and Service Evaluation, Section of
Psychiatry, Department of Public Health and Community Medicine,
Verona, Italy
13 University of Verona, WHO Collaborating Centre for Research and
Training in Mental Health and Service Evaluation, Section of
Psychiatry, Department of Public Health and Community, Verona,
Italy
∗ Corresponding author.
Introduction QTc interval prolongation is considered a risk fac-
tor for fatal polymorphic ventricular tachycardia, which can
result in sudden cardiac death. Most psychotropic drugs have
a dose-dependent potential to prolong the QTc interval. How-
ever, other factors require appropriate consideration, including:
age; gender; other medications; electrolyte abnormalities; severe
comorbid conditions, such as co-occurring alcohol or substances
abuse/dependence.
Objectives The objective was to study the potential mediating
roles of alcohol/substances abuse on QTc prolongation.
Aims The Italian research group STAR Network, in collaboration
with the Young Italian Psychiatrists Association, aimed to evaluate
the frequency of QTc interval prolongation in a sample of patients
under treatment with psychotropic drugs through a cross-sectional
national survey.
Methods A sample of 2411 unselected patients were enrolled
after performing an ECG during the recruitment period. Sociode-
mographic and clinical characteristics were collected frommedical
records. Collected data underwent statistical analysis.
Results A total of 11.2% of patients reported alcohol abuse, and
only 8.9% psychotropic substances. According to the threshold, less
than 20% of patients had a borderline value of QTc, and 1% a patho-
logical value. Patients with co-occurring alcohol misuse and drug
abuse were more likely to have longer QTc interval.