European Psychiatry - Volume 41 - April 2017

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S232 25th European Congress of Psychiatry / European Psychiatry 41S (2017) S170–S237
Objectives The aim of this study was to determine the levels
of depression, anxiety and attention-deficit hyperactivity disorder
symptoms and health-related quality of life (HRQL) in children and
adolescents with epilepsy.
Methods The sample consisted of 75 children with epilepsy and
50 healthy controls aged 8–18 years. Questionnaires were used to
evaluate the psychiatric status and HRQL of the patients.
Results Patients had lower child-rated psychosocial and total
area HRQL scores, and lower parent-rated psychosocial, physi-
cal and total area HRQL scores than the controls did. Inattention
scores of the epilepsy group were significantly higher compared to
controls. No significant differences were found between patients
and controls in terms of anxiety and depression scores. Regarding
determinants of HRQL, severity of depression and anxiety had a
decreasing effect on child-rated HRQL total scores; and severity of
anxiety had a decreasing effect on parent-rated HRQL total scores.
Conclusions Epilepsy is associated with poor QoL in childhood
and severity of depression and anxiety are among the determi-
nants of QoL. Clinicians should be more aware of accompanying
psychiatric symptoms in epileptic patients and take the necessary
precautions in the early period of the illness in an effort to improve
QoL.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0372
The new great
imitator – neuropsychiatric
symptoms of Lyme disease
M.C. Cochat Costa Rodrigues ∗, I. Moreira , M.J. Peixoto ,
C. Silveira
1 Magalhães Lemos Hospital, Psychiatry, Porto, Portugal
2 Hospital D. a Estefânia, Centro Hospitalar de Lisboa Central,
Department of Child and Adolescent Psychiatry, Lisboa, Portugal
3 Centro Hospitalar de São João, Clinic of Psychiatry and Mental
Health, Porto, Portugal
∗ Corresponding author.
Introduction Lyme disease, caused by the spirochete Borrelia
burgdorferri as recognized as a possible cause of multisystemic sig-
nals and symptoms, including symptomatology of the central as
well as the peripheral nervous system.
Objectives Identification of neuropsychiatric symptoms associ-
ated with Lyme disease.
Methods Literature review in the light of researched articles pub-
lished in Pubmed/Medline as well as related bibliography.
Results Since the identification of the etiology of syphilis in the
early twentieth century, mental health professionals consider the
fact that serious psychiatric symptoms can be caused by infections
of the central nervous system and that early antibiotic treatment
can prevent permanent neurological/psychiatric damage. Syphilis
was known as “the great imitator” because its multiple mani-
festations mimic other known diseases. In recent years, a new
epidemic, also with multiple manifestations emerged–Lyme dis-
ease, also known as the “new great imitator”. Like syphilis, Lyme
disease may be associated with neuropsychiatric symptoms, which
means that often these cases are initially referred for psychi-
atric services, before another diagnosis is made. The incorrect
assessment of these patients as individuals with functional psy-
chiatric disease can result in a delay in the start of antibiotic
treatment and may cause serious neurological and psychiatric
damage.
Conclusions According to the review, the authors propose that
in the evaluation of acute psychiatric disease or atypical chronic
disease, with poor therapeutic response, Lyme disease should be
considered and ruled out, especially if there is epidemiological con-
text and absence of psychiatric family antecedents.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0373
Attention, vigilance and visuospatial
functioning in hospitalised elderly
medical inpatients – relationship to
delirium syndromal status and motor
subtype profile
C. Daly
University of Limerick, psychiatry, limerick, Ireland
Objective The early and efficacious detection of neurocognitive
disorders poses a key diagnostic challenge. We examined how bed-
side cognitive tests perform across the spectrum of delirium and
motor subtypes.
Methods The performance on a battery of bedside cognitive tests
were compared in elderly medical inpatients with DSM-IV delir-
ium, subsyndromal delirium, and no neuro cognitive disorder and
in motor subtypes.
Results One hundred and ninety-eight patients (mean age
79.14± 8.26) were assessed with no delirium (n = 43), subsyndro-
mal delirium ( n = 45), and full syndromal delirium (n = 110). The
ability to meaningfully engage with the tests varied from 59% for
vigilance B test to 85% for Spatial Span forward test and was found
to be least in the full syndromal delirium group. The no delirium
group was distinguished from the delirium groups for all the tests
and from the full syndromal delirium group for the vigilance B test
and global visuospatial function test. The subsyndromal delirium
group differed from the full syndromal delirium group in respect
of global visuospatial function test, spatial span backwards and
vigilance A tests. Patients with full syndromal delirium were best
identified using the interlocking pentagons test and clock drawing
test whereas those with subsyndromal delirium were best iden-
tified using interlocking pentagons test and months backwards
test. Those with subsyndromal delirium were significantly better
in their ability to engage than those with full syndromal delirium.
Conclusions Simple bedside tests of attention, vigilance, and vis-
uospatial ability are useful to help to distinguish neurocognitive
disorders namely subsyndromal deliriumfromother presentations.
Disclosure of interest The author haS not supplied his/her decla-
ration of competing interest.
EW0374
The effects of bariatric surgery on
pharmacokinetics of antidepressants:
A systematic review
L. de Jonge ∗, S. Petrykiv , J. Fennema , M. Arts
1 Leonardo Scientific Research Institute, Geriatric Psychiatry, Bergen
op Zoom, The Netherlands
2 University of Groningen, University Medical Center Groningen,
Department of Clinical Pharmacy and Pharmacology, Groningen, The
Netherlands
3 GGZ Friesland, Geriatric Psychiatry, Leeuwarden, The Netherlands
4 University of Groningen, University Medical Center Groningen,
Department of Old Age Psychiatry, Groningen, The Netherlands
∗ Corresponding author.
Introduction Morbid obesity (BMI ≥ 35) has been associated with
mood and anxiety disorders. Regular use of antidepressants is com-
mon among patients who are candidate for bariatric surgery. The
Roux-en-Y gastric bypass (RYGB) is one of the most common tech-
niques used in bariatric surgery for reducing nutrient absorption.
This type of surgery may however result in major changes in drug
absorption.