European Psychiatry - Volume 41 - April 2017

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S278 25th European Congress of Psychiatry / European Psychiatry 41S (2017) S238–S302
cortisol measured in 5 time points during the TSST. Patients with
FEP experience more levels of baseline cortisole, and less changes
during the stress test then controls. Baseline stress levels indi-
cated in the salivatory cortisole levels correlate with perceived
self-esteem, psychological and social quality of life.
Conclusion Our findings support the alterations of stress
response, possibly indicating vulnerability to stress in persons with
FEP.
Funding This work was funded by the grant of the Croa-
tian Science Foundation No UIP-2014-09-1245 Biomarkers in
schizophrenia – integration of complementary methods in longi-
tudinal follow up of first episode psychosis patients.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0505
Executive function assessment in
young hospitalized schizophrenic
patients with the “CANTAB
Schizophrenia Battery”
(Russian sample)
G. Rupchev ∗, A. Alekseev , M. Morozova , V. Kaleda ,
A. Tkhostov , D. Tikhonov , A. Listova
1 Federal State Budgetary Scientific Institution “Mental Health
Research Center”, Laboratory of Psychopharmacology, Moscow,
Russia
2 Moscow State University, Department of clinical psychology,
Moscow, Russia
∗ Corresponding author.
Introduction Impairment of executive function is the fundamen-
tal feature of the cognitive dysfunction in schizophrenia has to
be measured throughout the illness regularly. Computerized tech-
nologies for assessment of cognitive dysfunction are widely used.
However, their applicability in hospitalized schizophrenic patients
setting should be specially examined.
Objective Executive function in schizophrenia.
Aims To test the applicability of “CANTAB” neurocognitive bat-
tery for measurement of executive function in young hospitalized
schizophrenic patients in Russian sample.
Methods Fifteen inpatients diagnosed with schizophrenia
according to ICD-10 (F 20.хх), 13 males and 2 females, aged
23.5(SD 3.2), disease duration is 5(SD 1.6) years and 16 healthy
individuals, 7 males and 9 females, aged 21.3(SD 0.7). Spa-
tial Working Memory (SWM) (Mnemonic Executive function),
Stockings of Cambridge (OTS) (Planning Executive function),
Intra/Extra-Dimensional Shift (IED) (Cognitive flexibility) were
administered.
Results The majority of patients and controls easily understood
the test instructions. Both groups did not have any difficul-
ties with the touchpad. The “CANTAB” demonstrated sensitivity
to the impairments of executive function. As a group, patients
with schizophrenia performed significantly worse than con-
trols on almost all tests: SWM–Between errors (P= 0.028), Total
errors (P= 0.019), Strategy (P = 0.03), Mean time to last response
(P = 0.001); OTS–Mean choices to correct ( P= 0.044), Problems
solved on first choice (P = 0.009), Probability of error given correct
(P = 0.021); IED–Total errors (P = 0.015), Total trials (P = 0.002).
Conclusion The “CANTAB” is an applicable instrument for assess-
ment of the executive function in young hospitalized schizophrenic
patients. It can be used both for experimental and clinical needs.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0506
Psychological traits of skin picking
disorder and psychogenic itch
G. Rupchev ∗, M. Vinogradova , A. Malyutina , A. Tkhostov ,
A. Ryzhov
1 Federal State Budgetary Scientific Institution “Mental Health
Research Center”, Laboratory of Psychopharmacology-, Moscow,
Russia
2 Moscow State University, Department of clinical psychology,
Moscow, Russia
3 Lomonosov Moscow State University, Faculty of Psychology,
Department of clinical psychology, Moscow, Russia
4 Lovonosov Moscow State University, Department of clinical
psychology, Moscow, Russia
∗ Corresponding author
Introduction Despite the intense discussion of psychiatric
comorbidity in psychodermatology, research on psychological
components of skin picking and psychogenic itch is limited, espe-
cially when it concerns patients’ representation of skin perception
and their attitude towards disease.
Objectives To characterize psychological traits of skin picking and
psychogenic itch disorder by comparing aspects of bodily experi-
ence.
Aims To reveal internal relations of different components of bod-
ily experience in skin picking and psychogenic itch.
Methods Thirty patientswith skin picking disorder (L98.1) and 18
patientswithpsychogenic itch (F45.8) participated in the study. The
psychosemantic method “Classification of sensations” was used to
assess bodily experience. It includes estimation of 80 descriptors
from 6 classes of bodily sensations: skin (ex. “itch”), inner body
(ex. “sickness”), receptor (ex. “sticky”), emotional (ex. “anxiety”),
dynamics (ex. “exhaustion”) and attitudinal descriptors (ex. “bad”).
Cluster and factor analysis were performed.
Results The most significant aspect of bodily experience in skin
picking was its dynamics as a transition from irritation to calmness
connectedwith the sensation of itch opposed to all other sensations
(there were opposite signs of factor loadings of these variables and
theywere included in the factor explaining 45% of total variance). In
contrast, in psychogenic itch these relations are diffuse and consist
of connections between skin sensations and inner bodily sensations
and descriptors of emotions reflecting functional origin of disorder.
Conclusion Traits of psychological components in skin picking
disorder and psychogenic itch should be concerned in the complex
(psychiatric, psychological and dermatological) treatment of these
disorders.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0507
Interaction of symptoms and
cognitive dysfunction in remitted
schizophrenic patients with and
without residua – important sign of
heterogeneity for design of cognitive
enhancer studies
G. Rupchev ∗, M. Morozova , D. Burminskiy
Federal State Budgetary Scientific Institution “Mental Health
Research Center”, Laboratory of Psychopharmacology, Moscow,
Russia
∗ Corresponding author.
Introduction It iswell-known fact that cognitive dysfunction (CD)
determines the quality of remission in patients with schizophrenia.
However many attempts to demonstrate the link between symp-
toms and CD failed. The reason for this fact is unclear.