European Psychiatry - Volume 41 - April 2017

425 / 916

25th European Congress of Psychiatry / European Psychiatry 41S (2017) S405–S464 S421
EV0052
Risk factors for suicide behaviors in
bipolar disorder: A closer look
D. Durães ∗, J. Martins , R. Borralho
Centro Hospitalar Barreiro-Montijo, Mental Health and Psychiatry
Department, Barreiro, Portugal
∗ Corresponding author.
Introduction Suicide behaviors (suicide acts and suicide
attempts) are a major concern for clinicians treating patients
with psychiatric disorders. Among them, patients with bipolar
disorder (BD) have the highest prevalence of suicide behaviors,
accounting for up to one-quarter of all completed suicides. Addi-
tionally, suicide remains the leading cause of avoidable death in
patients with BD.
Aims This work aims to review the main risk factors for suicide
behaviors in patients with BD.
Methods TheMEDLINE/Pubmed databasewas searched using the
keywords “bipolar disorder”with: “suicide”; “suicide attempt”; and
“suicide risk factors”. Articles published in the last 10 years were
considered.
Results It is estimated that 25% to 50% of patients with BD will
attempt suicide at least once in their lifetime and, that 10% to 15%
will die. The risk factors for suicide behaviors in patients with BD
have been widely studied and their knowledge is crucial for iden-
tifying patients at risk.
The main risk factors include previous suicide attempts, family his-
tory of suicide and hopelessness. Other risk factors have also been
identified: depressive polarity of first mood episode; rapid cycling;
increasing severity of affective episodes; depressive polarity of the
latest mood episode; mixed affective states; early age of onset; and
comorbid anxiety disorders, substance use disorders and cluster B
personality disorders.
Conclusions Prevention of suicide behaviors is crucial when
treating patients with BD. Therefore, the knowledge of these risk
factors is of extreme importance in order to promptly identify
patients at risk and adopt the proper preventive therapeutic inter-
ventions.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV0053
Mindfulness effects on cognition:
Preliminary results
A. Flores ∗, G. González , G. Lahera , C. Bayón , M. Bravo ,
B. Rodríguez Vega , C. Avedillo , R. Villanueva , S. Barbeito ,
M. Saenz , A. García Alocén , A. Ugarte , A. González Pinto ,
M. Vaughan , L. Carballeira , P. Pérez , P. Barga , N. García ,
C. De Dios
1 Hospital Universitario La Paz, Department of Psychiatry, Madrid,
Spain
2 Universidad de Alcalá, Department of Medicine and Medical
Specialties, School of Medicine, Madrid, Spain
3 Hospital Universitario Araba, Department of Psychiatry,
Vitoria-Gasteiz, Spain
∗ Corresponding author.
Background Mindfulness-based cognitive therapy (MBCT) is a
psychotherapeutic intervention that has been shown effective in
several clinical conditions. Nevertheless, research is still needed on
its effectiveness on cognition.
Objective To analyze possible effects on cognition of the addition
of MBCT intervention versus a brief structured group psycho-
education to the standard treatment of subsyndromal bipolar
depression. Our hypothesis was that MBCT could improve some
aspects of cognitive function to a higher degree than psycho-
education and treatment as usual (TAU).
Methods/design A randomized, multicenter, prospective, versus
active comparator, evaluator-blinded clinical trial was conducted.
Forty patients with BD and subclinical or mild depressive symp-
toms were randomly allocated to:
– MBCT added to psychopharmacological treatment (n = 16);
– a brief structured group psycho-educational intervention added
to psychopharmacological treatment (n = 17);
– standard clinical management, including psychopharmacological
treatment (n = 7).
Assessments were conducted at screening, baseline, post-
intervention (8 weeks) and 4-month follow-up.
Results Cognition results point to significant improvement in
Stroop Color test as well as processing speed in TMT A test (P < 0.05)
in the two psychological intervention groups versus TAU.
Conclusion These preliminary findings suggest that the addition
of MBCT or psycho-education to usual treatment could improve
some cognitive dimensions in subsyndromal bipolar depressive
patients.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV0054
The blue-eyed man: A case of
Waardenburg syndrome type 1
associated with mania and autistic
spectrum disorder
B. Francis∗, S.T. Jambunathan , J.S. Gill , S. Wong
University Malaya, Department of Psychological Medicine, Kuala
Lumpur, Malaysia
∗ Corresponding author.
Waardenburg syndrome (WS) is a rare genetic disorder charac-
terised by varying degrees of sensorineural deafness, dystopia
canthorum, musculokeletal defects, pigmentation anomalies such
as bright blue iris, greying hair and in some cases intestinal pathol-
ogy.
A 21-year-old Chinese gentleman, diagnosed with WS type 1
at the age of two, presented at the emergency unit
with manic symptoms for the past one month such as irritability,
grandiosity, flight of ideas and reduced need for sleep. With regards
to social integration, he had features suggestive of autism spectrum
disorder (ASD). He often played by himself and was fixated on par-
ticular toys. He was eventually admitted to the psychiatric ward
for acute management of mania. He was stabilised on olanzapine
10mg BD and sodium valproate 600mg BD. His sodium valproate
was cross-titrated with lithium in the ward and his manic features
gradually subsided. He was discharged well after 2 weeks of admis-
sion with lithium 300mg BD and olanzapine 10mg BD. WS type 1
has been localised to the locus 2q35 and researchers have identified
that a tetranucleotide repeat marker on 2q35 is strongly associated
with recurrent mood symptoms.
In conclusion, it is important to note that individuals with WS may
be at higher risk to develop ASD and mood disorders.
Fig. 1