European Psychiatry - Volume 41 - April 2017

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S46 25th European Congress of Psychiatry / European Psychiatry 41S (2017) S8–S52
In order to get a deeper understanding of these processes, valid
“disease models” are pivotal. A new cutting edge technique, named
brain organoids, has been highlighted as a promising candidate for
obtaining a better “disease model”.
Brain organoids derived from patients induced pluripotent stem
cells (iPSC) follow in vivo timeline development; they also have
the ability to recreate the right complexity of the brains, develop-
mental stages. On the cellular and gene expression level, organoids
demonstrate a high similarity to the developing brain in vivo and
can therefore recapitulate early stages of the neurogenesis. To
date organoids are the most relevant cellular in vitro platform
for the understanding of the mechanisms behind ADS pathology.
Investigations of “mini brains” at different time points in their
development will give a wider and more detailed picture of the
disease dynamic and thus the development of therapeutic and pre-
vention strategies. It is a tool that can be used for effective high
throughput screening of chemical compounds as potential drugs
(“in sphero” drug testing). Organoids are a good modeling system
for elucidating the role of epigenetic and environmental factors for
development of ASD.
Disclosure of interest The authors declare that they have no com-
peting interest.
Symposium: Clinical and neurobiological impact
of physical exercise interventions in
Schizophrenia
S126
The impact of endurance training on
brain structure and function in
multi-episode Schizophrenia
B. Malchow
Ludwig-Maximilians University, Department of Psychiatry and
Psychotherapy, Munich, Germany
Structural and functional brain alterations as well as cog-
nitive deficits are well-documented findings in schizophrenia
patients. Cognitive impairments affect the long-term outcome of
schizophrenia and are the main contributors to disability. Despite
their clinical impact, however, no effective options are available to
treat them sufficiently. Aerobic endurance training has been shown
to have effects on brain plasticity, gray and white matter volume
as well as functional connectivity measures and on cognitive func-
tioning in animal models and healthy humans. However, effects
of physical exercise in combination in combination with cognitive
remediation are unknown in Schizophrenia. 21 chronic schizophre-
nia patients and 21 age and gender–matched healthy controls
underwent 3 months of aerobic exercise (endurance training,
30 min, 3 times per week). 21 additionally recruited schizophre-
nia patients played table soccer (known as “foosball” in the USA)
over the same period. After 6 weeks of endurance training or table
soccer, all participants commenced standardized cognitive training
with a computer-assisted training program. We could show that
a 3-month endurance-training program combined with CR ther-
apy had positive effects on everyday functioning in multi-episode
Schizophrenia patients. Deficits improved frommedium to mild as
assessed with the GAF. Negative symptoms, short and long-term
verbal memory and cognitive flexibility also improved with train-
ing. We could demonstrate grey matter volume increase in the
left temporal lobe in schizophrenia patients undergoing endurance
training. A non-endurance and coordinative training stimulus like
playing table soccer led to a clearly distinct pattern of grey matter
alterations in Schizophrenia patients.
Disclosure of interest The author declares that he has no compet-
ing interest.
Symposium: Current evidence for
pharmacological and psychological interventions
in the treatment of borderline personality
disorder–Findings from two-updated Cochrane
reviews
S127
Short-term psychological
interventions for bordeline
personality disorder–What Works?
O.J. Storebø ∗, J. Stoffers-Winterling , J. Mattivi , B. Völlm ,
M.L. Kielsholm , S. Nielsen , E. Simonsen , K. Lieb
1 Psychiatric Research Unit, Psychiatric Department, Slagelse,
Denmark
2 University of Mainz Medical Center, Department of Psychiatry and
Psychotherapy, Mainz, Germany
3 Klinik für Psychiatrie und Psychotherapie Universitätsmedizin,
Department of Psychiatry and Psychoterapy, Mainz, Germany
4 Institute of Mental Health-Jubilee Campus, Division of Psychiatry
and Applied Psychology, Nottingham, United Kingdom
5 Psychiatric Research Unit, Department of Psychiatry, Slagelse,
Denmark
6 University of Maintz Medical Center, Department of Psychiatry and
Psychotherapy, Mainz, Germany
∗ Corresponding author.
Introduction Borderline personality disorder (BPD) is a common
and disabling personality disorder associated with difficulties in
controlling emotions and impulses, self-injury, feelings of empti-
ness and abandonment. It is associated with problems in many
areas of life, most notably relationships. Psychotherapy is the first-
line treatment for people with borderline personality disorder
widely used; however, the evidence is not thoroughly investigated.
In addition, several specific short-term interventions have been
developed during the last decades.
Objectives We are currently updating this cochrane collabora-
tion review on psychological interventions for BPD. First findings
on the up-to-date evidence relating to short-term psychological
interventions will be presented.
Methods We conducted a cochrane systematic review and
meta-analysis of randomized controlled trials (RCTs). Any random-
ized comparisons of psychological interventions versus unspecific
control interventions, waitlist or specific psychotherapeutic inter-
ventions in adult BPD patients were eligible. Primary outcomes
were BPD core pathology as depicted by DSM criteria. Secondary
outcomes included depression, anxiety, general psychopathol-
ogy, dropouts and adverse events. Two independent researchers
selected trials, assessed quality and extracted data independently.
Results The current evidence of short-term psychological inter-
ventions in general and the different types of interventions for
which RCT evidence is currently available will be evaluated.
Disclosure of interest The authors declare that they have no com-
peting interest.