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25th European Congress of Psychiatry / European Psychiatry 41S (2017) S8–S52 S45
of perception, concentration, memory retention and long-term
memory. A recent short screen for cognitive impairment in psy-
chiatry (SCIP) has addressed five domains of cognitive function:
verbal learning–immediate, working memory, verbal fluency, ver-
bal learning–delayed and processing speed
Using the SCIP in admissions from a defined catchment area in the
southwest of Vienna we confirm the presence of cognitive deficits
in schizophrenic patients and to a lesser degree in bipolar patients.
The deficits were present in all five domains and no discriminatory
pathognomonic signs could be found between schizophrenia and
bipolar disorder.
Recently, possibly selective deficits in social cognition have been
described in schizophrenic patients e review the evidence on
the specificity of social impairment to schizophrenia.
Disclosure of interest The authors declare that they have no com-
peting interest.
Reference
[1] Guy W, Ban TA (Eds.). The AMDP-System. Manual for the
Assessment andDocumentation of Psychopathology. NewYork:
Springer, Berlin Heidelberg; 1982.
[2] Purdon SE. The Screen for Cognitive Impairment in Psychia-
try (SCIP): Instructions and three alternate forms. Edmonton,
Alberta: PNL Inc; 2005.
[3] Lee J, Altshuler L, Glahn DC, Miklowitz DJ, Ochsner K, Green
MF. Social and nonsocial cognition in bipolar disorder and
schizophrenia: relative levels of impairment. Am J Psychiatry
2013 Mar;170(3):334–41.
S123
From (Psycho) pathology to diagnosis:
psychiatry nosology beyond
dichotomy
A. Erfurth ∗ achs
1 Otto-Wagner-Spital, 6th Psychiatric Department, Vienna, Austria
2 Medical University of Vienna, Department of Psychiatry and
Psychotherapy, Vienna, Austria
∗ Corresponding author.
As in all medical disciplines, diagnosis in clinical psychiatry should
be reached in a step-wise approach: after assessing the chief com-
plaint of the patient, a careful examination of the psychopathology
follows e.g. by using the AMDP system o preliminarily conclude
the process with a syndromal classification This syndromal
classification is of great importance as it guides the initiation of
therapy in daily life practice. After gaining additional information
(e.g. investigation in the course of the disease, brain imaging, thor-
ough assessment of cognitive function, exclusion of organic causes)
a final diagnosis is possible. Unfortunately, a premature jumping
to diagnosis is not uncommon (with the potential consequence of
incorrect therapies).
In addition to these difficulties, recent neurobiological research
has shown that nosologic assignments through conventional diag-
nostic classifications are far less specific than assumed, revealing
a large overlap between diagnostic categories .g. between
Schizophrenia and affective disorders. Consequences of this find-
ing are discussed both for the construction of future classification
systems and for therapy.
Disclosure of interest The authors declare that they have no com-
peting interest.
Reference
[1] Guy W, Ban TA (Eds.). The AMDP-System. New York: Springer,
Berlin Heidelberg; 1982.
[2] Hippius H. Psychiatrie. In: Geriatrie/Psychiatrie. Taschenbücher
Allgemeinmedizin. New York: Springer, Berlin Heidelberg;
1979. p. 67–138.
[3] Cross-Disorder Group of the Psychiatric Genomics Consor-
tium. Genetic relationship between five psychiatric disorders
estimated from genome-wide SNPs. Nature genetics 45.9
2013:984–99.
[4] The Network and Pathway Analysis Subgroup of the Psychiatric
Genomics Consortium. Psychiatric genome-wide association
study analyses implicate neuronal, immune and histone path-
ways. Nature neuroscience 18.2 2015:199–209.
Symposium: Autism spectrum disorders: From the
neurobiology to interventions
S124
Psychosis and autism spectrum
disorders
M. Kyriakopoulos
London, United Kingdom
Autism spectrum disorders (ASD) and schizophrenia were sep-
arated into different diagnostic categories in the late 1970’s
(DSM-III) having previously been considered as related diagnos-
tic entities. Since then, several lines of evidence have indicated that
these disorders showclinical and cognitive overlaps aswell as some
common neurobiological characteristics. Furthermore, there is a
group of patients presenting with ASD and psychotic experiences
who pose particular diagnostic and management challenges and
may represent a subgroup of ASD more closely linked to psychosis.
Evidence from a study of the first empirically derived classification
of children with ASD in relation to psychosis based on three under-
lying symptom dimensions, anxiety, social deficits and thought
disorder, will be presented. Further phenomenological, genetic and
neuroimaging research on the clinical boundaries and overlapping
pathophysiology of ASD and psychosis may help better define their
relationship and lead to more effective interventions. Understand-
ing this relationship will also provide a framework of working with
patients with mixed clinical presentations.
Disclosure of interest The author declares that he has no compet-
ing interest.
S125
Neurobiology of autism spectrum
disorders
T.M. Sheldrick-Michel ∗, B.T. Morten , B. Niels , I. Mirolyuba
1 Psychiatry, Denmark
2 Institute of Clinical Research University of Southern Denmark,
Department of Psychiatry, Odense, Denmark
3 Psychiatry at the Region of Southern Denmark and Institute of
Clinical Research, University of Southern Denmark, Department. of
Child and Adolescent Psychiatry, Odense, Denmark
4 Psychiatry at the Region of Southern Denmark and Institute of
Clinical Research, University of Southern Denmark, Department of
Psychiatry, Odense, Denmark
∗ Corresponding author.
Autism Spectrum Disorders (ASD) is a group of neurodevel-
opmental disorders with heterogeneous etiology characterized
by deficits in social cognition, communication, and behav-
ioral flexibility. Disturbances on molecular and cellular level
in early brain development incl. intercellular communication,
an unbalanced ratio between certain neuronal populations and
maturation/differentiation process, oxidative stress, happening in
embryonal stages, might be promising candidates to explain the
development of autistic symptoms.