European Psychiatry - Volume 41 - April 2017

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25th European Congress of Psychiatry / European Psychiatry 41S (2017) S8–S52 S49
Symposium: Social science and biological findings
informing research in suicidal behavior
S134
Electrodermal reactivity and suicide
M. Sarchiapone
University of Molise, Psychiatry, Campobasso, Italy
Electrodermal Activity (EDA) refers to changes in electrical conduc-
tance of the skin. Electrodermal hyporeactive individuals are those
who showan unusual rapid habituation to identical non-significant
stimuli. Previous findings suggested that electrodermal hyporeac-
tivity has a high sensitivity and a high negative predictive value
for suicide. The aim of the present study is to test the effectiveness
and the usefulness of the EDOR® (ElectroDermal Orienting Reac-
tivity) Test as a support in the suicide risk assessment of depressed
patients.
One thousand five hundred and seventy three patients with a pri-
mary diagnosis of depression, whether currently depressed or in
remission, have been recruited at 15 centres in 9 different European
countries. Depressive symptomatology was evaluated through the
Montgomery-Asberg Depression Scale. Previous suicide attempts
were registered and the suicide intent of the worst attempt was
rated according to the first eight items of the Beck Suicide Intent
Scale. The suicide riskwas also assessed. During the EDOR® Test two
fingers are put on gold electrodes and a moderately strong tone is
presented through headphones now and then during the test. The
EDOR® Test is able to register the electrodermal responses to those
tones, along with the blood volume in the fingers. Each patient is
followed up for one year in order to assess the occurrence of suicidal
behaviors.
Expected results would be that patients realizing a suicide attempt
with a strong intent or committing suicide should be electroder-
mally hyporeactive in most cases and non-hyporeactive patients
should show only few indications of death intent or suicides. Pre-
liminary findings will be presented.
Disclosure of interest The participating centres received funding
for this study by EMOTRA AB, Sweden.
S135
Neural patterns in ecological
momentary assessment of social
stressors
P. Courtet ∗, E. Olié , M. Husky , J. Swendsen
1 CHU Lapeyronie, Emergencic Psychiatry, Montpellier, France
2 CHU Lapeyronie, Emergency Psychiatry, Montpellier, France
3 University of Bordeaux, Laboratoire de Psychologie EA4139,
Bordeaux, France
4 University of Bordeaux, CNRS- UMR 5287 INCIA, Bordeaux, France
∗ Corresponding author.
Background Suicidal behaviors result from a complex interaction
between social stressors and individual vulnerability. Ecological
Momentary Assessment (EMA) provides the opportunity to inves-
tigate the relationship between social stressors in daily life and the
occurrence of negative thoughts leading to suicidal ideation. fMRI
showed that a neural network supports the sensitivity to social
stressors in suicide attempters.
Objective A joint fMRI/EMA study investigated whether individ-
ual differences in brain reactivity to scanner-based social rejection
was related to social rejection during real-world social interactions.
Method Sixty women were included: euthymic women with
a history of depression with or without suicidal behavior and
healthy controls. The Cyberball Game was used as a social exclu-
sion paradigm. Following the fMRI, subjects used EMA for seven
days, providing data on environmental, contextual and emotional
factors.
Results In the fMRI study, in comparison to patients without any
history of suicide attempt and healthy controls, suicide attempters
showed decreased activation in the posterior cingulate cortex,
insula and superior temporal gyrus during the exclusion vs. inclu-
sion condition. In the EMA study, social stressors were specific
predictors of suicidal ideation in suicide attempters. We will exam-
ine here if individuals who show greater activity in specific brain
regions during scanner-based social rejection reported a greater
social distress during their daily social interactions.
Conclusions this study used a combined technique to assess
whether neural reactivity to experimental social rejection in the
scanner is related to real-world social experience, and if it may help
to understand the sensitivity to social stress in suicidal behavior.
Disclosure of interest The authors declare that they have no com-
peting interest.
S136
A review of advances in social sciences
and their application for research in
suicidal behavior
J. Lopez Castroman
Nîmes University Hospital, Gard, Nimes, France
Suicidal behavior and its prevention constitute a major public
health issue, and the moderating effect of sociodemographic fac-
tors has been studied for more than a century. In the last years it
has become evident that the relationship between social factors
and suicidal behavior is complex and highly dependent on the con-
text. For instance, minorities suffering marginalization, such as the
Inuit in Canada or the aborigines in Australia, present high rates of
suicide. However, other minorities, such as immigrants arriving to
tightened communities, can be protected from suicide compared to
the social majority. Other contradictory effects have been reported
concerning income per capita and the evolution of the economy.
Unfortunately, the interplay of social factors in suicidal behavior
and the social consequences of suicide attempts are rarely rep-
resented in theoretical models of suicidal behavior, despite their
importance to adapt suicide prevention policies to social groups at
risk. In this presentation, recent advances and new and integrative
avenues for future research in the social aspects of suicidal behavior
will be summarized.
Disclosure of interest The author declares that he has no compet-
ing interest.
S137
MicroRNA profiling in postmortem
brain and plasma exosomes:
Biomarker perspective of suicidality
Y. Dwivedi
University of Alabama at Birmingham, Psychiatry and Behavioral
Neurobiology, Birmingham, USA
Introduction Suicide is a leading cause of death. Although
research on the biological aspects of suicide is accumulating, there
is no testable biomarker to assess suicidality. miRNAs, small non-
coding RNAs, have been implicated in synaptic plasticity, genetic
susceptibility to stress and coping to stress response. Because of
the presence of microRNAs in circulating body fluids, miRNAs can
not only be used as regulators of disease pathologies but also in
prognosis and treatment response.
Objectives Whether miRNAs can be used as biomarker for suici-
dality.