European Psychiatry - Volume 41 - April 2017

508 / 916

S504 25th European Congress of Psychiatry / European Psychiatry 41S (2017) S465–S520
review will facilitate the understanding of symptoms in order
to effectively diagnose and provide a holistic early treatment
approach.
Methods A case report of a 72-year-old woman with bilateral
cerebellar lesions with high pre-morbid function presented with
classic symptoms of CCAS. Multidisciplinaryworkup includedmed-
ical, psychiatric, neuropsychological assessment (R-BANS (Form
1), Digit Span, Verbal fluency tests, the Hayling Test, the Delis-
Kaplan Executive Function System) as well as other investigations
(neuroimaging and blood tests) were conducted on the patient to
confirm CCAS and exclude other differential diagnoses.
Results The results from the medical assessments conducted
showed symptoms of cerebellar dysfunction. A psychiatry and
neuropsychological review revealed aggression, irritability, dis-
inhibition, deterioration in cognitive function and personality
changes. A multidisciplinary team was formed to rehabilitate the
patient however patient was non-compliant with therapy. The
patient was prescribed Seroquel 50 XR and she responded well to
the medication.
Conclusion This case review illustrates the challenges associated
with engaging a CCAS patient in rehabilitation activities due to cog-
nitive andmood disorders. The use of psychotropicmedications can
be an effective method in improving cognition and mood disorders
in CCAS patients. Early psychiatry and psychological intervention
can significantly improve the overall outcome of a patient diag-
nosed with CCAS.
Funding source Nil.
Disclosure of interest The author has not supplied his declaration
of competing interest.
EV0308
Neuropsychiatric and behavioural
manifestation in a rare lysosomal
storage disorder (Fabry’s Disease):
A case study
D. Roy
The Prince Charles Hospital Metro North Health Services, Acute Care
Team, Departement of Psychiatry, Chermside, Australia
∗ Corresponding author.
Introduction Case presentation of a young woman Ms. SH, with
neuropsychiatric presentation in a rare Lysosomal Storage Disorder
(Fabry’s disease).
Case report A 19-year-old female with Fabry’s disease (FD)
presented initially with symptoms of obsessions of dirt and con-
tamination and compulsions of washing and also with overvalued
persecutory ideas of being followed. Since the age of 14, she had suf-
fered from various psychiatric symptoms increasing in frequency
and intensity. Routine examinations including cognitive testing,
electroencephalography and structural magnetic resonance imag-
ing revealed no pathological findings. During the course of a year,
her OC symptoms improved significantly with the use of Fluoxe-
tine 40mg mane. However, she then became more depressed and
psychotic (despite continuing on Fluoxetine). Addition of Risperi-
done (gradually increased to 2mg nocte) led to attenuation of her
symptoms and she recovered completely over a course of another
6 months.
Discussion Mental and behavioural symptoms in Fabry Disease
symptoms usually begin during late childhood or adolescence but
may not become apparent until the second or third decade of
life. Early symptoms include episodes of severe burning pain in
the hands and feet and skin lesions. The psychiatric manifesta-
tions can be varied, e.g. the index patient, initially presented with
what appeared like an Obsessive Compulsive disorder but later as
a depressive illness (Muller et al,. 2006) with psychotic symptoms.
Conclusions To showcase mental and behavioural symptoms
associated with a rare disorder like Fabry’s disorder and treatment
options may be helpful.
Disclosure of interest The author has not supplied his declaration
of competing interest.
EV0309
Referrals of patients with
schizophrenia to a
consultation-liaison psychiatry
service
R. Sánchez González ∗, E. Baillès Lázaro ,
S. Herranz Villanueva , L. Pintor Pérez
1 Institut de Neuropsiquiatria i Addiccions. Parc de Salut Mar.,
Department of Psychiatry, Barcelona, Spain
2 Institut de Neurociències. Hospital Clínic i Provincial de Barcelona.
Institut d’Investigacions Biomèdiques August Pi i Sunyer.,
Department of Psychiatry, Barcelona, Spain
∗ Corresponding author.
Background There are few studies specifically investigating the
acute treatment procedures of patients with schizophrenia in the
context of Consultation-liaison psychiatry (CLP).
Purpose Describe the main clinical features of the referrals of
patients with schizophrenia, attended by a general hospital CLP
service.
Methods Longitudinal observational and descriptive study,
assessing adult inpatients with schizophrenia (DSM-IV-TR criteria)
admitted to non-psychiatric units of Hospital Clínic of Barcelona
(Spain), who were consecutively referred to our CLP service over a
10-year period (from January 1, 2005, through December 31, 2014).
Results During that period, 9.808 psychiatric consultations were
requested. 163 of them (1.8%) concerned patients with schizophre-
nia. These groups of patients were aged 50.9 ± 15.3 years and 65%
were male. A 25.9% of patients had history of suicide attempts and
45.6% presented current psychosocial stressors.
Characteristics of referrals Referral sources according to medical
specialties are shown in
The major medical conditions for referral according to ICD-10
categories were: external causes of morbidity (21.5%), infectious
diseases (13.5%) and diseases of the digestive system (10.4%).
The two most frequent reasons for referral were the assessment of
psychopharmacological treatment and/or psychopathological state
examination (62%) and suicidal risk/attempt assessment (8.6%).
Conclusions In our sample, only a 1.8% of all patients for
whom psychiatric consultation was requested had a diagnosis of
schizophrenia. The most common profile of them was: male, 50
years old, coming from general medicine department due exter-
nal causes of morbidity and referred to the CLP service because of
psychiatric state and/or medication review.