European Psychiatry - Volume 41 - April 2017

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25th European Congress of Psychiatry / European Psychiatry 41S (2017) S645–S709 S653
1024 pressure levels). These test were implemented on a graphic
tablet (Wacom Intuos) with the specialized software. The length
and time of drawing, the average and maximum speed of drawing,
the average and maximum momentary speed, the amplitude and
frequency (with FFT spectrum analysis) of hand tremors were
measured.
Results Statistical analysis of the graphomotor signal revealed
differences between the AD group and the C group with respect
to various parameters. The largest differences have been observed
in partially automated skills such as signature, and not drawing
shapes (lines, spiral, etc.). The average speed of signature and max-
imum momentary speed of signature is lower in the AD group.
Conclusions This method allows for quantitative and objective
measurement of the biophysical signal and assessment of the
graphomotor skills.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV0762
The diagnostic value of saccadic
profile in Alzheimer’s disease
P. Walecki , K. Pasgreta , E.J. Gorzela ´nczyk ∗
1 Jagiellonian University Medical College, Faculty of Medicine,
Krakow, Poland
2 Collegium Medicum, Nicolaus Copernicus University, Department of
Theoretical Biomedical Sciences and Medical Informatics, Bydgoszcz,
Poland
∗ Corresponding author.
Introduction Appearing in the early stages of the disease patho-
logical changes in different parts of the brain in Alzheimer’s disease
(AD) subjects cause disruption of neural circuits between the cortex
and the basal ganglia. It may affect the ocular movement distur-
bances.
Objectives In previous studies we have shown that AD patients
present abnormalities of saccadic eye movements. In this study,
we conducted for the first time the advanced quantitative analysis
profile of saccades on a large study group.
Aims The aim of this study is to find the features and the
values of parameters in patients with AD differ from healthy
individuals using quantitative measurement methods that could
help in the future to differentiate people with an uncertain
diagnosis.
Methods Seventy-one patients with mild and moderate AD (age
79.1 ±5.21) were examined. Forty-four healthy ones (C) without
symptoms of dementia, matched for sex, age and education level
(age 78.3 ± 4.7) were examined. In this study we made use of
the Saccadometer Advanced (ACI, Cambridge, UK), allowing the
measurement of eye position with the time resolution of 1ms
(1000Hz).
Results Statistically significant differences between AD and C
groups were found (P < 0.05). The analysis of saccadic profile allows
to differentiate Alzheimer’s disease. The rising slope duration and
the rising slope percent is lower in AD group, but the falling slope
duration and the falling slope percent is larger in AD group.
Conclusions AD patients have much smaller slope in the rising
phase of the saccade. The results show that the use of saccadometry
may improve diagnosis of the AD.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV0763
Quality of life and depression in
caregivers of patients with cancer
I. Feki , S. Hentati , R. Sallemi , M. Moala , J. Masmoudi ∗
University Hospital Hédi Chaker Sfax, Tunisia, psychiatry, sfax,
Tunisia
∗ Corresponding author.
Background Most elderly patients, with cancer are cared for, by a
family member who may be affected by various stressors that can
influence their health and quality of life (QOL).
Objectives To explore depression, quality of life and its related
factors among caregivers of elderly patients with cancer.
Methodology This is a descriptive and analytical cross-sectional
study including 40 primary caregivers of old patients aged 65 or
older, with cancer in oncologic radiotherapy service in university
hospital Habib Bourguibain Sfax, Tunisia. The short form health
survey (SF-36) and Beck inventory (13 items) were used to assess
respectively QOL and depression.
Results The average age of caregivers was 44.62 years. The sex
ratio (M/F) was 0.9. Most of caregivers (75%) had impaired QOL
(score < 66.7). The two main components of SF-36 were altered
with a standard score of 45 for the physical component and 41.1
for mental component. According to Beck inventory, Depression
was present in 67.6% of cases. Impaired QOL of life was signifi-
cantly correlated with somatic illnesses in the caregiver (P = 0.016),
advanced stage of cancer (P = 0.01), financial difficulties (P = 0.04),
the non-cohabitationwith the patient before the disease (P = 0.031)
and depression (P = 0.00).
Conclusion According to our study, caregiving can have a nega-
tive effect on the caregiver’s mental and physical health. Assistance
and information from healthcare professionals are the key to
improving the ability of caregivers to cope with caring for older
patients with cancer.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV0764
Pain assessment in people with
dementia
I. Feki , S. Hentati , R. Sallemi , I. Baati , J. Masmoudi∗
University Hospital Hédi Chaker Sfax, Tunisia, psychiatry, sfax,
Tunisia
∗ Corresponding author.
Introduction Assessing and quantifying the experience of pain in
elderly with cognitive impairment is particularly challenging and
important.
Objectives To describe the overall profile and to identify the
prevalence and characteristics of pain among demented elderly.
Methods A descriptive study including 60 institutionalised
elderly aged 65 and older in the retirement home, Sfax, Tunisia.
Data collectionwas conducted using questionnaire exploring socio-
demographic and medical data. Mini-mental state examination
(MMSE) and Katz index of independence in activities of daily
living (ADL) were used to assess respectively mental status and
dependence for ADL. Verbal Descriptor Scale (VDS) and elderly
behavioural scale (ECPA) were used to evaluate pain. Thirty-two
elderly were included and the inclusion criteria were: Age ≥ 65 and
MMSE score ≤ 20.
Results The average age of cognitively impaired residents was
74.2 years with a slight male predominance (57%). They were
mostly illiterate (83%) and 56.3% of subjects were single. Almost
two-thirds were admitted voluntarily and the average length of
staywas 4.8 days. TheADL scale has shown that 65.6%were depend-
ent. According to the VDS, the majority of demented subjects
(93.8%) did not feel and express pain, 3% of residents with demen-
tia had mild pain, 2.2% had moderate pain and 1.1% had severe
pain. Whereas, the hetero evaluation (ECPA) concluded that 72% of
demented elderly actually had pain with severe pain in 18.8% of
cases.