European Psychiatry - Volume 41 - April 2017

658 / 916

S654 25th European Congress of Psychiatry / European Psychiatry 41S (2017) S645–S709
Conclusion Pain in elderly persons with dementia is a significant
problem. This underlines high needs of research as well as excellent
implementation concepts for assessment and treatment of pain.
Disclosure of interest. The authors have not supplied their decla-
ration of competing interest.
EV0765
Depression in elderly patients with
schizophrenia
I. Feki , K. Mdhaffar , S. Hentati , R. Sallemi , J. Masmoudi ∗
University Hospital Hédi Chaker Sfax, Tunisia, psychiatry, Sfax,
Tunisia
∗ Corresponding author.
Background The presence of depressive symptoms impacts neg-
atively the lives of patients suffering from schizophrenia-spectrum
disorders. Likewise, the treatment poses many challenges for clini-
cians.
Objectives To specify the profile of elderly with schizophrenia
and to evaluate the prevalence of depression and its related factors.
Methods A descriptive and analytic study involved 40 elderly
patients aged 65 and over with DSM-5 diagnoses of schizophrenia
or schizoaffective disorder, followed to the outpatient psychiatry
department of Hedi Chaker University Hospital, in Sfax, Tunisia,
during the two months of September and October 2015. Positive
andnegative syndrome scale (PANSS) andCalgary depression scales
were used to assess respectively the symptoms of schizophrenia
dimensionally and depression.
Results The majority of our patients was male (62.5%), single
(55%), with low school and socioeconomic level. The mean dura-
tion of disease was 45 ± 6.02 years and patients were mostly (90%)
in classical neuroleptics. The scale of PANSS showed the predomi-
nance of negative symptoms (67.5% of cases). In addition, according
to Calgary scale, depression was found in 25% of patients. Factors
positively correlated to depression were: the female sex among
single (P = 0.043), absence of family support (P = 0.001), treatment
with conventional neuroleptics (P = 0.039) and negative symptoms
(P = 0.001).
Conclusion Depression in patients with schizophrenia is far from
exceptional. It is often difficult to diagnose due to the recovery of
other symptoms.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV0766
Pupillometric assessment of
cholinergic functioning in people with
Alzheimer disease: A study from India
A.Q. Jilani ∗, S. Srivastava , D. Shukla , S.C. Tiwari
1 ERA’S Lucknow Medical College, Psychiatry, Lucknow, India
2 King George’s Medical University, Geriatric Mental Health,
Lucknow, India
3 Ram Manohar Lohia Hospital, Psychiatry, Lucknow, India
∗ Corresponding author.
Background Diagnosis of Alzheimer disease is mainly clinical,
based on longitudinal history and clinical criteria due to lack of
specific biochemical tests and neuroimaging studies. Deficient cen-
tral cholinergic activity of AD pathology is said to be reflected
as decreased peripheral cholinergic activity. Assessing peripheral
cholinergic function with pupillometer for diagnostic and prog-
nostic purpose may be beneficial, as it may be a non-invasive,
acceptable, and easily administered diagnostic tool if proven so.
Method This is a single point case control pilot study with sam-
ple size of 45 (25 AD patient and 20 controls). CAMDEX-R based
interview, HMSE, andDSM-IV criteriawere used for detailed assess-
ment and diagnosis. The pupillometric parameters (Horizontal and
vertical diameters of pupil) were measured by Oasis Colvard pupil-
lometer (SKU-0401A) under three conditions namely after 5minute
of dark adaptation in dark room (PD-5min-DA i.e. Baseline PD);
after 5minutes (PD-5min-T) and15minutes (PD-15min-T) of instil-
lation of 2–3 drops of 1.0% Tropicamide.
Results There was no difference in baseline pupil diameter (hor-
izontal + vertical) of AD patients and age matched healthy controls.
1% tropicamide induced significant increment in pupil diameters
from baseline to after 5 (‘PD-5min-T’) and 15minutes (‘PD-15min-
T’) of its instillation in both AD patients and age matched healthy
controls. But tropicamide induced increment in pupil diameters
were approximately equal in cases and controls.
Conclusion The study did not find the role of 1% tropicamide
induced pupillary hypersensitivity in AD patients for diagnostic
purpose.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV0767
The burden of caregivers of patients
with Alzheimer
G. Jmii ∗, L. Robbana , F. Ghali , M. Zghal , M. Mezghani ,
J. Lamia , R. Rafrafi
1 Mongi slim hospital, Department of Psychiatry, Tunis, Tunisia
2 Razi Hospital, Department of Psychiatry, Tunis, Tunisia
∗ Corresponding author.
Introduction The Alzheimer’s patient assistance relationship is a
morally painful experience, most frequently discussed in terms of
“burden” in the literature, especially as professionals and institu-
tional intermediaries are underdeveloped in Tunisia.
Goal It is intended to assess the level of burden among care-
givers of patients with Alzheimer’s disease and to search factors
associated with a high level of burden.
Methodology This is a retrospective descriptive study. Patients
were recruited from neurology department of Razi hospital, which
were hospitalised between the months of December 2012 and
March 2013. The burden was measured using the Zarit inventory.
Results and discussion Thirty patients were included. The major-
ity female, most caregivers are descendants (60%), then, daughters
in law (33%), and finally the spouses (23%). 80% of caregivers lived
in the same home as patients. Caregivers were asked about all the
items of the grid Zarit. The average burden in our sample is 59.9 + 16
3. We observed that 33% have absent to light burden (score <21),
10% have a light to moderate burden (between 21 and 40), 36, 66%
have moderate to severe burden (between 41 and 60) and 50%
have a severe burden (>60), according to the classification proposed
by Zarit. Sex, kinship and cohabitation with the patient were not
associated with a higher burden.
Conclusion The study of factors correlated with high levels of
burden aims at finding ways of intervention and support to fight
against the isolation of caregivers and the occurrence of anxiode-
pressive complications.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV0768
Cognitive symptoms: The border
between dementia and depression,
a report of one case
M. Juncal Ruiz ∗, O. Porta Olivares , L. Blanco Sánchez ,
R. Landera Rodríguez , M. Gómez Revuelta ,
G. Pardo de Santayana Jenaro , N.I. Nú˜nez Morales ,