European Psychiatry - Volume 41 - April 2017

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S758 25th European Congress of Psychiatry / European Psychiatry 41S (2017) S710–S771
SSRIs. Fluoxetine and sertraline are also likely to be safe, evenwhen
combined with atorvastatin, simvastatin, and lovastatin.
Conclusion Though the absolute risk of concomitant use of SSRIs
with statins seems to be negligible, even this risk can be minimized
by using lower statin doses and monitoring the patient.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV1089
Hyponatremia associated with
selective serotonin-reuptake
inhibitors
S. Petrykiv ∗, L. De Jonge , M. Arts
1 University Medical Center Groningen, Department of Clinical
Pharmacy and Pharmacology, Groningen, The Netherlands
2 Leonardo Scientific Research Institute, Department of Geriatric
Psychiatry, Groningen, The Netherlands
3 University Medical Center Groningen, Department of Old Age
Psychiatry, Groningen, The Netherlands
∗ Corresponding author.
Introduction Psychotropic agents have been implicated in the
cause of hyponatremia, including the majority of selective sero-
tonin reuptake inhibitors (SSRIs). The reported incidence of
hyponatremia caused by SSRIs varies widely up to 40%. Important
risk factors are older age and concomitant use of diuretics. Though
there are numerous retrospective studies available, an update of
current knowledge SSRI induced hyponatremia is warranted.
Objectives and aims To review the incidence, risk factors, mecha-
nism, times of onset and resolution, and treatment of hyponatremia
associated with selective serotonin-reuptake inhibitors (SSRIs).
Methods An English language literature search was con-
ducted using Pubmed, EMBASE and Cochrane library (December
1980–December 2015) using the search terms selective serotonin-
reuptake inhibitor, hyponatremia, syndrome of inappropriate
secretion of antidiuretic hormone, citalopram, escitalopram, flu-
oxetine, fluvoxamine, paroxetine, and sertraline.
Results Numerous case reports, observational studies, and case-
controlled studies, as well as one prospective clinical trial, have
reported hyponatremia associated with SSRI use, with an incidence
of 15%. Risk factors for the development of hyponatremiawith SSRIs
include older age, female gender, and concomitant use of diuretics,
low body weight, and lower baseline serum sodium concentra-
tion. Predisposing factors, such as volume status, diuretic use, or
concomitant use of other agents known to cause SIADH, may pre-
dispose to the development of hyponatremia. In published reports,
hyponatremia developed within the first few weeks of treatment
and resolved within 2weeks after therapy was discontinued.
Conclusion Practitioners should be on the alert for this potentially
life-threatening adverse event, especially in older adults.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV1090
Drug safety warnings in psychiatry:
Adverse drug reactions’ signaling
from 2002 to 2014
V. Prisco ∗, T. Iannaccone , A. Capuano , M. Fabrazzo ,
F. Catapano
1 University of Naples SUN, Department of Psychiatry, Naples, Italy
2 University of Naples SUN, Department of Experimental Medicine,
Section of Pharmacology L. Donatelli, University of Naples SUN,
Naples, Italy
∗ Corresponding author.
Monitoring drug-related side effects in psychiatric patients
is highly recommended. In fact, frequent exposure to long-
term polipharmacotherapy, poor compliance to pharmachological
treatment and co-morbidity with organic illnesses requiring
the prescription of other drugs are causes of pharmacoki-
netic/pharmacodynamic interactions. These vulnerability factors
result in a certain increase in ADRs (adverse drug reactions). This
study performs an analysis of the Italian medicine agency (AIFA)
data, in the section “signal analysis”, to attempt an assessment
of the safety warnings among the different psychotropic drug
classes, belonging to the ATC class: N03 (anti-epileptics), N05 (anti-
psychotics), N06 (psycho-analectic drugs). Then we analyzed, in a
descriptive way, the different association between the drug and the
related ADR, evaluating the different safety profiles, in relation to
experimental studies, supporting the importance of the signal. In
the last years, among the new 25 ADRs, 10 were related to antide-
pressant drugs (8 SSRI, 1 mirtazapine, 1 agomelatine). In relation
to anti-psychotic drugs, 6 new correlations were found between
drug and ADR onset, mainly among atypical anti-spychotics. Other
correlations (6 above all) were found among anti-epileptic drugs.
Among benzodiazepines, a signal linked to rabdomylysis onset was
found. It is also recommended an evaluation of safety profile in rela-
tion to zolpidem prescription. The results of our systematic review
are a motivational input, considering the continuous increase of
safety warnings, to attentively monitor drug’s prescription. Spon-
taneous ADRs’ signaling is a classical systemto provide the required
attention in relation to a potential risk.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV1091
Protection of proteins and lipids of
blood plasma by different lithium
salts under ethanol-induced oxidative
damage
V. Prokopieva ∗ arygina lotnikov
1 Mental Health Research Institute, Tomsk National Research Medical
Center, Russian Academy of Sciences, Laboratory of Clinical
Psychoneuroimmunology and Neurobiology, Tomsk, Russia
2 Tomsk Polytechnic University, Department of Physical and
Analytical Chemistry, Tomsk, Russia
∗ Corresponding author.
Introduction The creation of new lithium compounds with
antioxidant activity is relevant problem for psychiatry. The aim of
this work was study of the protective effect of lithium salts against
ethanol-induced oxidative damage to proteins and lipids of human
blood plasma in vitro.
Methods We used lithium ascorbate and lithium carbonate
0.6mmol/L which correspond to the therapeutic dose (in terms
of lithium ions). Antioxidant carnosine ( -Ala-L-His) was used
as comparison drug. We used the blood of 12 healthy donors.
The heparinized blood samples were incubated in presence of
tested preparations for one hour at 37 ◦ C. The final ethanol
concentration in samples was 0.5%. Oxidative modification of pro-
teins was determined as the level of carbonylated proteins with
2.4–dinitrophenilhydrazine, lipid peroxidation products–as the
level of TBA-reactive products by spectrometry. Statistical analysis
was performed with “Statistika 10” program.
Results The addition of ethanol in the blood led to a sig-
nificant increase in carbonylated proteins and TBA-reactive
products in the plasma (carbonylated proteins: without ethanol
0.26 ±0.01 nmol/mg of protein; with ethanol 0.33 ± 0.02 nmol/mg;
TBA-reactive products: without–3.2 ± 0.1 nmol/mL; with–4.0
±0.2 nmol/mL, P< 0.05). In the presence of carnosine such increase
of oxidized products of biomolecules is not observed, i.e. carno-
sine had a protective effect against ethanol-induced oxidative