European Psychiatry - Volume 41 - April 2017

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25th European Congress of Psychiatry / European Psychiatry 41S (2017) S772–S846 S801
some neuropsychiatric states. There is evidence that patients with
schizophrenia have altered corticocerebellar connectivity.
Objectives To evidence a case with early onset psychosis accom-
panied with brain structural abnormalities.
Method Case description.
Results The patient is 15 years old girl with an acute psy-
chotic episode. For more than two months she had demonstrated
odd behavior, getting around all the time purposelessly, aban-
doned school etc. She presented with disorders of perceptions,
disorganized speech, insomnia and fluctuations in her mood and
behavior. In her brain, MRI was found vermian atrophy, and
CT was found hypocampal glyosis and dilatation of temporal
corn.
Conclusions Although the structural mapping studies have
been equivocal, the weight of evidence supports extending the
study of cerebellar activity in schizophrenia. For example, the
finding that unaffected first-degree relatives of probands with
schizophrenia have reduced cerebellar volumes, along with the
observation of reduced cerebellar volumes in neurolepticnaïve
patients with schizophrenia, suggests that cerebellar atrophy
may be a hereditary trait rather than a psychotropic associated
epiphenomenon.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV1215
Traumatic brain injury as psychosis
development factor
A. Alonso Sánchez ∗, A. Álvarez Astorga , H. De la Red Gallego ,
M. De Lorenzo Calzón , N. De Uribe Viloria , M. Gómez García ,
C. Noval Canga , E. Mayor Toranzo , J.A. Blanco Garrote
Hospital Clinico Universitario de Valladolid, Psychiatry, Valladolid,
Spain
∗ Corresponding author.
Introduction The pathophysiology of psychosis is not fully dis-
covered yet. However, during the last years many different risk
factors are shown to prove to have a strong influence within the
development of this pathology. Traumatic brain injury (TBI) is one
of them.
Objectives Show TBI as a psychosis development risk factor.
Methods Case report. A clinical vignette is presented followed by
the results obtained in a bibliographic review.
Results A young 19-year old immigrant man, who lives with his
parents in a social exclusion situation is brought to the hospital
after having been observedmaking estrange religious ritualswithin
a local river. During the anamnese he declares that God is “getting
in touch with him” while he shows to be changed, with suspicion
about being pursued. He also reveals to have suffered a mild-severe
TBI with 8 years, having right ear audition problems since then.
During the hospitalization some medical test were done, such as
MRI, showing the lack of the inner right ear, as well as white matter
abnormalities in his right hemisphere, which could be consequence
of the TBI. Those findings make us think that this pathology might
have been influenced, within other factors, by the traumatic brain
injury.
Conclusions This bibliographic review shows that traumatic
brain injury may increase the risk of developing psychosis up to
65% fromhealthy controls, with amediumgap of 3.3 years between
the TBI and the appearance of psychotic pathology.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV1216
Psychosis and creativity. Genetic and
structural relation between them
A. Alonso Sánchez ∗, H. De la Red Gallego , A. Álvarez Astorga ,
M. Gómez García , N. De Uribe Viloria , M. De Lorenzo Calzón ,
S. Gómez Sánchez , S. Cepedello Pérez , J.A. Blanco Garrote
Hospital Clinico Universitario de Valladolid, Psychiatry, Valladolid,
Spain
∗ Corresponding author.
Introduction Madness and creativity are thought to be related
from ancient ages. Nowadays, thanks to new scientific develop-
ments and researches we are able to identify common genetic and
brain patterns between creativity and psychosis.
Objectives Taking the inspiration of a psychotic patient with
some shocking drawings, we want to get deep into the actual
knowledge about the relation between creativity and psychosis.
Methods Case report and bibliographic review.
Results A 19-year-old man was brought to the hospital after hav-
ing been found making strange rituals in the public way. In the
anamnese he showed to have experienced mystic delusions and
hallucinations. He made some particularly creative drawings.
We made a review which showed that this patients may have a
diminished latent inhibition, which could make them experiencing
usual live irrelevant stimuli as something very exciting and cre-
ative at the same time. Genome wide association studies show also
that people having creative jobs and psychotic patients share some
genes, which could be linked to this abnormal latent inhibition.
Conclusions Latent inhibition abnormalities couldbe relatedwith
psychosis and creativity. There are differences within the course of
people having this oversensibility, which could be explained due
to the presence of protective and risk factors.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV1217
A fine line between schizophrenia and
Hashimoto encephalopathy
I. Amado
Centro Hospitalar Médio Tejo, Psiquiatria, Coimbra, Portugal
Introduction Hashimoto encephalopathy (HE) is an uncommon
syndrome associated with Hashimoto thyroiditis. The relationship
between these entities is unclear. Even being rare, it appears to be
underrecognized.
Objectives Report a case of an atypical presentation of psychosis
in a patient with elevated serum levels of antithyroid antibodies
and review the literature about similar situations.
Methods Access clinical process, research PubMed, using the
mesh terms “Hashimoto encephalopathy” and “psychosis”.
Results A 21-year-old Portuguese female was conducted by
authorities to our emergency department after she called for help
and was spotted walking barefoot on the streets. Throughout
clinical course she presented persecutory ideas, thought blocks,
auditory hallucinations, soliloquies, perplexity, total insomnia,
bizarre behaviors like coprophagia, trichotillomania and self-
injured burns. After some tests, it was found that the patient had
high serum levels of antithyroid peroxidase antibody (TPO) and
antithyroglobulin antibody (TGO) and reduced folic acid, without
other changes. Trials with corticosteroids showed clinical improve-
ment for short periods, as with antipsychotics. No consistent
remission was achieved with either approaches.
Conclusion HE is an uncommon syndrome presenting with high
titers of antithyroid antibodies that may preconize an acute state
of atypical psychosis. Usually, it responds to corticosteroids and so,
has a generally good prognosis when treated accordingly. Evidence