European Psychiatry - Volume 41 - April 2017

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S822 25th European Congress of Psychiatry / European Psychiatry 41S (2017) S772–S846
enriched cortical glutamatergic neurons and parvalbumin-positive
GABAergic interneurons populations that are under inspection to
reveal phenotypic and molecular/pharmacological aspects corre-
lating with patient-specific responsivity pattern to CLZ treatment.
These results might help to unveil the molecular basis of treat-
ment response profiles that can be exploited to predict response to
antipsychotic drugs and that might help to develop personalized
treatments, more individually tailored and less hazardous.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV1273
Organic psychosis: Much more than
dopamine
R. Martín Gutierrez ∗, M. Juncal Ruiz , O. Porta Olivares ,
R. Landera Rodríguez , L. Sánchez Blanco , D. Abejas Díez ,
G. Pardo de Santayana Jenaro , M. Gómez Revuelta ,
C. Marín Requena , V. Gajardo Galán
1 Hospital Universitario Marques De Valdecilla, Psychiatry,
Santander, Spain
2 Hospital Universitario de Álava-Sede Santiago, Psychiatry,
Vitoria-Gasteiz, Spain
3 Hospital Clínic, Psychiatry, Barcelona, Spain
∗ Corresponding author.
Introduction Most of elderly onset psychosis present as a conse-
quence of one or more organic processes. We present the case of
an 81-year-old patient with diagnosis of a posterior fossa menin-
gioma. It emergedwith abrupt positive symptoms of psychosiswith
important family and social disruption. The interest of the case lies
in the low frequency of psychiatric symptoms associated to this
type of tumor, given its location. Thus, these symptoms may be
explained, by normal pressure hydrocephalus (NPH) secondary to
the tumor.
Objectives To highlight the importance of performing a complete
organic screening in elderly onset psycotic patients.
Material and method From the mentioned case, we performed a
literature review of psychopathology associated with NPH.
Results Psychiatric examination demonstrated parasitization
delusions and delusional misinterpretations; tactile and visual
zoomorphic hallucinations were also present. They were compati-
ble with Ekbom syndrome; anxiety and behavioral disorganization
were prominent. We introduced treatment with risperidone
0.5mg/12 h with important decrease of positive psychotic symp-
toms. Currently, the patient is waiting for a ventricular-peritoneal
shunt.
Conclusions TheNPHusually presentswithmemory failures, psy-
chomotor slowing, problems in calculating and writing. It may
progress to a neurological impairment so intense that may be indis-
tinguishable from Alzheimer’s disease. From a psychopathological
point of view, affective or psychotic symptoms and/or behavioral
disorganization may also appear. In few cases, HNT onset shows
with prominent psychiatric symptoms instead of neurological
impairment. These symptoms may improve with pharmacologi-
cal and surgical treatment. Thus, it is important to get an accurate
diagnosis.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV1274
Reasons to choose a long acting
antipsychotic and tolerability
I. Martínez Molina ∗, N. Gómez-Coronado Suárez de Venegas ,
P. Blanco Ramón
Hospital Universitario Virgen del Rocío, Salud Mental, Seville, Spain
∗ Corresponding author.
Introduction Aripiprazole depot is an atypical antipshycotic used
to treat positive and negative symptoms of psychosis or acute
mania.
Aim Describe the reason why psychiatrists switch the current
antipsychotic treatment on to aripiprazol depot, its tolerability and
the reasons to stop aripiprazol depot treatment.
Methods Descriptive analysis based on a sample of 37 patients,
aged 18–65 years, treated during one year with antipsychotics at
two community mental health units.
Results Switching on to aripiprazole depot principal reasons:
promote adherence (25%), persistence of symptoms (25%) and high
levels of prolactin or sexual dysfunction (16.66%):
– side effects of aripiprazole depot: insomnia (11.11%), inquietude
(8.33%), sexual dysfunction (2.77%) and hypertensive crisis during
administration (2.77%);
– 83.33% of the patients are still taking it after one year. The most
common reasons to stop or change it were the presence of secon-
daries (11.11%) and clinical exacerbation (5.55%).
Conclusions Aripiprazole depot is well tolerated (even better
than other antipsychotics). Common side effects are not severe and
appear in a small percent of patients.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV1275
Psychological resilience and quality of
life amongst people with psychotic
illnesses
G. McCarthy ∗, A. Liston , D. Adamis
NUI Galway and HSE West, Psychiatry Sligo Leitrim Mental Health
Services, Sligo, Ireland
∗ Corresponding author.
Introduction Psychological resilience is defined as an individ-
ual’s ability to adapt to stress and adversity. People with psychotic
illness often experience high levels of distress and difficulties
adapting.
Aims To assess the relationship between the resilience of people
with psychotic illnesses and their quality of life.
Methodology Outpatients frommultiple settings attending Sligo-
LeitrimMental Health Services, aged 18+ years old with a diagnosis
of either schizophrenia, bipolar affective disorder or schizoaf-
fective disorder were approached by their treating teams and
invited to participate. Other inclusion criteria were having a
family member. Drug induced psychoses or no family mem-
ber were exclusion criteria. The scales used were the Resilience
Appraisal Scale and the schizophrenia Quality of Life Scale. This
study is part of a larger study looking at family factors and
psychosis.
Results The study sample was 58 enrolled but only 49 partici-
pants completed the 2 assessments, of these 33weremales (67.3%).
Data was analysed using SPSS 21. Pearson’s correlation coefficient
for resilience and quality of lifewas 0.503, P < 0.001. This shows that
higher resilience is associated with better quality of life amongst
people with psychotic illnesses. These results could have useful
clinical implications. If we can intervene to therapeutically increase
resilience, we can eventually improve the quality of life of people
with psychoses.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.