European Psychiatry - Volume 41 - April 2017

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25th European Congress of Psychiatry / European Psychiatry 41S (2017) S772–S846 S827
(P < .05). SNPs associated with the first principal component of
the resulting enriched gene set were combined in a Polygenic
Co-Expression Index (PCI) We conducted Independent Com-
ponent Analysis (ICA) on attentional control fMRI data (n = 265)
and selected Independent Components (ICs) including the thal-
amus and being highly correlated with an attentional control
network2. Multiple regressions were conducted (predictor: PCI)
using a thalamic cluster previously associated with familial risk for
schizophrenia s ROI (FWE P < .05).
Results In one of the 8 ICs of interest there was a positive effect of
PCI on thalamic connectivity strength in a cluster overlapping with
our ROI (Z = 4.3).
Conclusion Decreased co-expression of genes included in PCI
predicts thalamic dysconnectivity during attentional control,
suggesting a novel co-regulated molecular pathway potentially
implicated in genetic risk for schizophrenia.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
References
[1] Pergola G, et al. Transl Psych 2016,
[In press].
[2] Antonucci LA, et al. Sch Res 2016;173:23–9.
[3] Ripke S, et al. Nature 2014;511:421–7.
EV1288
Erotomania: A psychodynamic
overview
E. Pereira ∗, F. Coutinho , A.S. Machado , C. Reis
Centro Hospitalar de São João, Clinic of Psychiatry and Mental
Health, Porto, Portugal
∗ Corresponding author.
Introduction Erotomania is a delusional disorder in which one
believes to be loved by someone else. Even though its etiology is not
known, psychodynamic factors have been proposed as a possible
explanation.
Objectives To review the psychodynamic etiology of erotomania.
Methods A search of the Medline/Pubmed database was con-
ducted using the terms “erotomania” and “psychodynamic”.
Results Several authors wrote about the psychodynamic etiol-
ogy of erotomania. Kraepelin describes it as a “compensation for
the disappointments of life”. De Clérambault highlights the idea of
“sexual pride”: stimulated by the absence of affective and sexual
approval, erotomania flourishes as a way of satisfying the individ-
ual’s pride. Hollender and Callahan explain the disorder as a result
of an ego deficit of not feeling attractive enough. According to Segal,
the erotomanic delusion meets the patient’s need for love and it is
related to the idea of it as the ultimate way of approval. Taylor high-
lights the patients’ isolation, loneliness and extreme dependence
on others.
Conclusions About every author agrees with the idea that the
erotomanic delusion acts as a gratification to the individual’s nar-
cissistic needs, when personal experience has failed to do so.
Wanting to be loved is the core of human motivation and the
delusion most commonly appears in people who feel rejected by
society; facing that perceived rejection, it emerges as the fantasy
that other human being is in love with them. This is a relevant
overview of this disorder with implications in patients’ treat-
ment, since psychotherapy could be important along with drug
treatment.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV1289
The association between first-episode
psychosis and abnormal glycaemic
control: Systematic review and
meta-analysis of clinical studies
B. Perry ∗, G. McIntosh , S. Weich , S. Singh , K. Rees
1 University of Warwick, Department of Mental Health and
Wellbeing, Warwick, United Kingdom
2 North West School of Anaesthesia, Anaesthetics, Manchester, United
Kingdom
∗ Corresponding author.
Background Schizophrenia, which is linked to a range of physi-
cal health conditions, might share intrinsic inflammatory disease
pathways with type-two diabetes mellitus (T2DM). Psychotropic
medication has presented a major confounder in examining this
association. First-episode psychosis (FEP) patients present an inter-
esting cohort to study this potential association, being generally
younger with less comorbidity, and with limited exposure to
antipsychotic medication.
Aims To assess whether FEP, which could be described as ‘devel-
oping schizophrenia’, is associatedwith prediabetes, or ‘developing
diabetes’, to determine whether intrinsic disease links could cause
the conditions to develop in unison.
Methods Using PRISMA criteria, we searched Embase, Medline,
PsychInfo, Web of Science, and Google Scholar to 6th January 2016.
We assessed case-control studies with biochemical assessment of
prediabetic states in FEP patients alongside matched controls.
Results Twelve studies were included, involving 1137 partic-
ipants. Several measurements examined prediabetes, including
fasting plasma glucose, impaired glucose tolerance, and insulin
resistance. Pooled analysis found FEP to be related to impaired glu-
cose tolerance (meandifference 1.31 [0.37, 2.25]), insulin resistance
(mean difference 0.30 [0.18, 0.42]), and the number of patients with
impaired glucose tolerance (odds ratio 5.44 [2.63–11.27]).
Conclusion Our findings suggest a potential link between predia-
betic markers, in particular impaired glucose tolerance and insulin
resistance, and FEP. However, we cannot establish causality, and the
studies contributing to this reviewwere at some risk of bias. Never-
theless, the findings might help to explain the increased prevalence
of T2DM in patients with schizophrenia and could have implica-
tions for the management of schizophrenia patients.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV1290
Patients with schizophrenia assessing
psychiatrists’ communication skills
A. Pestana Santos ∗, V. Santos , I. Carvalho
1 Coimbra Hospital and University Centre, Psychiatry, Coimbra,
Portugal
2 Faculty of Medicine of Oporto University, Psychology, Oporto,
Portugal
∗ Corresponding author.
The doctor-patient relationship constitutes the matrix of the entire
medical practice. One way in which doctors develop a positive rap-
port with their patients is through appropriate communication.
Evidence suggests that doctors do not communicate with their
patients as they should. Important gaps are observed in doctors’
communication with patients with schizophrenia.
Aim Examine psychiatrists’ communication skills as assessed by
their patients with schizophrenia and through external observa-
tion, considering patients’ socio-demographic and clinical variables
and analyse the importance that aspects of communication have for
patients.