European Psychiatry - Volume 41 - April 2017

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25th European Congress of Psychiatry / European Psychiatry 41S (2017) S772–S846 S845
Introduction schizoaffective disorder is a nosographic entity
characterized by a combination of symptoms of schizophrenia with
mood episodes. The fact that its diagnosis is difficult, and often
oscillates between schizophrenia and bipolar disorder raises the
problem of its care and the outcome of patients who suffers from
it.
Objective To evaluate the quality of life of treated patients with
schizoaffective disorder.
Materials and methods This is a cross-sectional study realized at
the psychiatric consultation of Mahdia hospital during a 6month
period. Data were collected from patients and from their medical
records using a predefined questionnaire.
Results A total of 52 patients were included, the average age was
38 years. The majority of patients (63.5%) were unemployed. The
use of psychoactive substances was noted in 63.5% of patients. Mul-
tiple linear regression analysis allowed us to find that 12 factors
were more significantly associated with impaired quality of life
which were, in descending order of importance: the EAS score > 39,
the EGF score ≤ 70, the null or partial adherence, the presence of
side effects seriously affecting daily activity, the depressive sub-
type, the lack of employment, the socio-economic level, the lack
of stable budgetary resources, an age > 60years, the widowed and
divorced marital status, the PANSS score (≥ 45) and negative sym-
ptomatology (PANSS).
Conclusion The diagnosis of schizoaffective disorder has a triple
relevance: clinical, prognostic and therapeutic. Identifying a
schizoaffective disorder and the risk factors that may affect the
quality of life provides a significant practical impact for the patient’s
benefit.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV1342
Schizoaffective disorder and life
events
B. walid ∗ arrag , F. Ellouze , A. Dekhil , M. Nasr
Hospital, psychiatrie, mahdia, Tunisia
∗ Corresponding author.
Introduction The schizoaffective disorder is multifactorial. Sev-
eral factors almost unquestioned, even indisputable, participate in
the episodes’ decompensation and affect various fields: biological,
pharmacological or neurobiochemical.
Objectives Draw up the sociodemographic and clinical profile of
patients treated for schizoaffective disorder and determine the role
of life events in the onset of the disorder.
Methods This is a retrospective study of 52 patients hospitalized
in the psychiatric department of Mahdia diagnosed with schizoaf-
fective disorder according to DSM-IV-TR during the period from
January 2014 until June 2014. The information was collected using
a preset sheet with 35 items.
Results A total of 52 records was gathered. The average age was
38 years. The sample was predominantly male, of rural origin in
61.5% of cases. The level of education was low in 59.6% of cases.
More than half werewithout profession and single in 46.2% of cases.
The mean age at onset of the disorder was 25.2 years. The presence
of life events preceding the onset of the disorder was noted in 22
patients, that to say, 42.3% of the sample. Family and emotional
events were most frequently encountered with respective rates of
48.2 and 24.7%, followed by the professional events (20%) and social
ones (6%).
Conclusion Life events are due to chance but also to the environ-
ment. The complexity of the “event” concept was again underlined
in a new perspective, breaking social rhythms.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV1343
EEG spectral power changes in solving
spatial logical task in schizophrenia
patients in the first episode and in
remission
Y. Zaytseva ∗, Z. Garakh , A. Morozova
1 National Institute of Mental Health, National IT System of Mental
Health and Brain Monitoring, Klecany/Prague, Czech Republic
2 Charles University in Prague, Prague, Czech Republic
3 Institute of Higher Nervous Activity and Neurophysiology of RAS,
Psychophysiology, Moscow, Russia
4 Charles University in Prague, 3rd Faculty of Medicine, Prague, Czech
Republic
∗ Corresponding author.
Introduction Despite the assumption that the EEG parameters in
schizophrenia may be predictive for the treatment outcome, there
are only a small number of such studies present. We hypothesised
that the characteristics of the changes in EEG rhythms during cogni-
tive loadmight differ in the first episode of psychosis and remission
being dependent on the stage of the illness.
Methods The EEG rhyths spectral power (SP) in the resting state
and their changes during the performance of spatial logical task
in 25 first-episode psychosis patients (FEP) and same patients in
remission (REM) after 6–18 months were analysed. Control group
included healthy subjects matched with patient group by gender,
age and years of education.
Results The resting state SP values did not differ in FEP and
REM. When performing a task, FEP theta SP was decreased
compared to the resting state values in F7, F8, P3, T6 sites
(P < 0.05), while gamma2 SP was increased in Fz (P < 0.001) and
Pz (P < 0.01). REM theta, alpha, and beta1 SP was decreased in
the same way as in norm in all sites (P < 0.05). Gamma2 SP
increase was found in sites Fp1, F8, Fz (P < 0.05). FEP theta and
beta1 SP changes during cognitive load positively correlated with
the PANSS scales (delusions, thought disorders, hallucinations).
REM did not have significant correlations between SP and PANSS
parameters.
Conclusions The analysed REM EEG characteristics differ less
from the norm than the FEP. Based on the results, the performance
of the task is related to the stage of the illness.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV1344
Serum testosterone level and its
relation to aggressive behavior in
schizophrenia
M. Zholob ∗, S. Godinova , M. Zelman
1 Psychiatricka nemocnica Hronovce, Acute male department,
Hronovce, Slovak Republic
2 Psychiatricka nemocnica Hronovce, Acute female department,
Hronovce, Slovak Republic
∗ Corresponding author.
This work is presenting partial preliminary outcomes of our study
focused on evaluating the levels of testosterone in psychotic
patients and its relationship to aggressive behavior.
Our study group included 10 male patients (from planned 20), with
history of aggressive behavior at baseline and 24 male patients
(from planned 40), without history of aggressive behavior. Non-
aggressive patients were considered as control group. All included
patients were hospitalized in psychiatric hospital Hronovce with
diagnose of psychotic disorder. Levels of testosterone were mea-
sured by laboratory evaluation. Aggressive behavior was assessed
byHCR scale, whichwas linkedwith every TSHevaluation. The level
of testosterone was measured in all subjects at the baseline and in