European Psychiatry - Volume 41 - April 2017

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S846 25th European Congress of Psychiatry / European Psychiatry 41S (2017) S772–S846
the group of aggressive patients was realized next measurement
after 14 days of hospitalization.
According to our preliminary findings, the average level of TSH
in our whole study group was 478.66 ng/dl (range from 158.06
to 767.81). The control group showed average value of TSH
486,84 ng/dl (range from 158.06 to 767.81). The group of patients
with history of aggressive behavior showed average value of TSH
459.04 ng/dl (range from191.81 to 638.02) and after 14 days of cure
the levels were of average value 452.55 ng/dl (range from 253.53
to 657.92).
These preliminary findings don’t show significant intergroup dif-
ferences, but there are some clear casuistic declines in TSH. After
collecting the envisaged group of patients we plan to correlate
values of testosterone level with the score of HCR, intergroup
comparison and detailed analysis (including demography, pharma-
cology).
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV1345
Belief inflexibility and dimensions of
delusional beliefs in non-affective
psychosis: Comparison with
non-clinical meaningful beliefs
C. Zhu ∗, S.H. So
The Chinese University of Hong Kong, Psychology, Shatin, Hong Kong
Special Administrative Region
∗ Corresponding author.
Introduction Belief inflexibility (BI) has been considered as a
crucial factor for delusional conviction, but less is known about
other dimensions of delusional beliefs. Question has been raised
regarding the extent to which BI distinguishes delusions from
strongly held (non-deluded) personally meaningful beliefs.
Objectives We examined the association between BI and major
dimensions of delusional beliefs/non-clinical personally meaning-
ful beliefs, and compared results from two BI measures (Maudsley
assessment of delusions schedule [MADS] and bias against discon-
firmatory evidence [BADE] task).
Methods Idiosyncratic delusional beliefs from 40 outpatients
with non-affective psychosis and personally meaningful beliefs
from 30 healthy controls were assessed in an interview. Belief
dimensions (conviction, preoccupation, and distress) and BI were
measured.
Results Compared with controls, patients reported higher levels
of distress and preoccupation but a comparable level of convic-
tion (3.30/4 vs. 3.00/4, t(66.967) = 1.928. P = n.s.). Patients exhibited
lower belief flexibility than controls on MADS but not on BADE. In
patients, delusional conviction was associated with lower flexibil-
ity on a MADS item (“possibility of being mistaken”: t(38) = 4.808,
P < 001) and the BADE evidence integration index (r = 0.463, P = 01).
In healthy controls, belief conviction was associated with lower
flexibility on a MADS item (“reaction to hypothetical contradic-
tion”: t(27) = 3.345, P=.002). Two-way ANOVA revealed that the
association between possibility of being mistaken and conviction
was stronger in patients than controls (F(1) = 6.718,P = 012). In both
groups, BI on either measure did not correlate with distress or pre-
occupation.
Conclusions BI was specifically associated with belief conviction.
The association was significant for both groups, and was stronger
in patients than controls.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.