European Psychiatry - Volume 41 - April 2017

854 / 916

S850 25th European Congress of Psychiatry / European Psychiatry 41S (2017) S847–S910
upstreamof the TSS of the CRH gene–was significantly hypomethy-
lated in hypersexual patients after corrections were made for
multiple testing using the FDR-method. Methylation levels of
cg23409074 were positively correlated with gene expression of the
CRH gene in an independent cohort of 11 healthy male subjects.
CRH is an important integrator of neuroendocrine stress responses
in the brain, modulating behavior and the autonomic nervous sys-
tem; our results show epigenetic changes in CRH gene related to
hypersexual disorder in men.
Disclosure of interest The author has not supplied his/her decla-
ration of competing interest.
EV1355
Female sexuality in the context of
dual control model
R. Kowalczyk ∗, K. Nowosielski , J. Kurpisz , M. Lew-Starowicz
1 Andrzej Frycz Modrzewski Krakow University, Department of
Sexology, Kraków, Poland
2 Medical College in Sosnowiec, Department of Sexology and Family
Planning, Sosnowiec, Poland
3 Pomeranian Medical University in Szczecin, Department of
Psychiatry, Szczecin, Poland
4 Institute of Psychiatry and Neurology, 3rd Psychiatric Clinic,
Warszawa, Poland
∗ Corresponding author.
Introduction Dual Control Model (DCM) is one of the contempo-
rary concepts of mechanisms rooted in the central nervous system
that control human sexual behaviors. The DCM holds promise for
application both in scientific settings and, although at the moment
limited, clinical practice. A number of psychometric tools, i.e. the
SIS/SES, SES II-W and SES II-W/M questionnaires based on the DCM
theoretical assumptions have been developed.
Methods A total of 309 women aged 18–45 were eligible for the
study. Inclusion criteria were met by 214 individuals who were
included in the further analysis. Sexual excitation/sexual inhibition
inventory for women (SESII-W) was used to evaluate sexual inhi-
bition and sexual excitation. Semi-structure interview was used
to evaluate sexual function in investigated individuals. Correlation
between risky sexual behaviors, FSD and SE/SE was measured.
Results Among the women, 28.5%were diagnosedwith FSD, with
orgasmic dysfunction being the most common, 11.2%. Engaging in
risky sexual behavior (having multiple sexual partners and one-
night-stand sexual relationships, sexual intercourse with persons
known to be HIV-positive, drug users or prostitutes, unprotected
vaginal, oral and anal sex, sex for money or drugs and sexual
activity while using alcohol and/or psychoactive substances) was
associated with higher sexual excitation scores and lower sexual
excitation scores of SESII-W. In contrast, the presence of FSD were
negatively correlated with SE and positively with SI.
Conclusions Dual control model might be a good model describ-
ing different sexual behaviors in the population of women.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV1356
Sexual excitation, sexual inhibition
and a prevalence of sexual disorders
among msm and heterosexual men
R. Kowalczyk ∗, M. Kaluga , K. Jacek , K. Nowosielski
1 Andrzej Frycz Modrzewski Krakow University, Department of
Sexology, Kraków, Poland
2 Pomeranian Medical University in Szczecin, Department of
Psychiatry, Szczecin, Poland
3 Medical College in Sosnowiec, Department of Sexology and Family
Planning, Sosnowiec, Poland
∗ Corresponding author.
Introduction Dual control model of the sexual response (DCM)
indicates, that there are two separate, but cooperating systems
of sexual excitation and inhibition. Previous studies using DCM
concept have shown, that MSM (men having sex with men) had
higher excitation (SES) and one of the types of inhibition (SIS1) lev-
els, in comparison to the exclusively heterosexual men. MSM also
reported more frequent occurrence of sexual disorders (erectile
disorders, premature ejaculation and decreased sexual desire).
Objectives Comparison of theMSMand heterosexual men groups
in order to verify erenow observed differences in sexual excita-
tion/inhibition propensity and prevalence of sexual problems.
Methods The sample consisted of two groups: 47 heterosexual
men and 60 MSM. The participants have anonymously filled up
questionnaires (Polish version of the Sexual Inhibition/Sexual Exci-
tation Scales SIS/SES and the author’s survey) via internet. Then
statistical analysis was executed.
Results Our findings have shown, that both groups were simi-
lar in their propensities for sexual excitation (SES) and inhibition
due to the risks of failure in sexual performance (SIS1), while MSM
scored higher on the inhibition scale, related to the threat of neg-
ative consequences of sexual response (SIS2). Heterosexual men
more frequently suffered frompremature ejaculation and less com-
monly reported decreased desire. There were no differences in the
erectile disorders report between MSM and heterosexual men.
Conclusions Our findings are mostly in conflict with previous
DCM studies results. Several issues, just like method of sexual ori-
entation assessment or cultural differences may had its impact on
such results. More detailed studies on these issues are required.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV1357
The under-diagnosed green-eyed
monster: Otello syndrome and how to
manage it
B. Latecki
LIfe Empangeni Private Hospital, Private psychiatric practice,
Empangeni, South Africa
Otello syndrome derives its name from Shakespeare’s drama
(character) and, clinically, describes a person with delusions
of the partner’s infidelity. A variety of other psychopathology
may present: obsessive-compulsive features, alcohol dependency,
voyeurism, sadism, possessiveness and domineering, hyper-
sexuality, paranoid attitude, abuse of different nature, violent
behaviour, including, occasionally, homicide. Yet, in the author’s
opinion, the syndrome, unless it presents itself as obviously absurd,
is frequently missed.
Management is rather difficult and does not always result in recov-
ery but, if not treated with neuroleptics, it would render any other
means of treatment useless. The condition could pose a diagnostic
challenge. Moreover, it also poses an ethical dilemma whether to
warn the spouse of the psychotic condition of the partner, the poor
prognosis and possible implications of its existence. Moreover, the
long-term partners of such patients frequently present with the
symptoms of dependency, submissiveness or even masochism.
The paper discusses the abovementioned issues, including the
likely psychodynamics, biological background, historical and social
elements and possible effective management.
Disclosure of interest The author has not supplied his/her decla-
ration of competing interest.