European Psychiatry - Volume 41 - April 2017

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25th European Congress of Psychiatry / European Psychiatry 41S (2017) S106–S169 S165
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EW0178
Psychiatric symptomatology as the
initial presentation of brain cancer
A. Fornelos∗, P. Macedo , A. Figueiredo , M. Roque
Psiquiatria e Saúde Mental, Centro Hospitalar Trás-os-Montes e Alto
Douro, Vila Real, Portugal
∗ Corresponding author.
Glioblastoma multiforme is the most common primary adult brain
tumor. Clinically, non-specific psychiatric symptoms may arise
as their first and only manifestation, prior to any neurological
deficits. The most form of psychiatric presentation of neurologi-
cal diseases are depressive complaints, although these may also be
accompaniedby behavioral and/or cognitive, anxious andpsychotic
symptoms. By explaining this case report we aim to emphasize the
importance of considering the diagnosis of an organic brain dis-
ease, even when only primary psychiatric symptoms are evident.
The bibliographic research was made using PubMed and Scielo,
and analysis of the electronic patient process. Man of 68 years
with a history of hypertension, nephrectomy, splenectomy and left
brachial plegia after a car accident. He had been previously seen by
a psychiatrist for a 6-month history of depressive symptoms, which
had been successfully treated. He later developed new behavioral
changes such as heteroaggressiveness, social maladjustment and
disfasia, for which he was sent to the emergency room. Brain-CT
scan displayed a left front temporal expansive injury. Admitted
to the Neurology Department for further diagnostic investigation.
Subsequent MRI, detected massive infiltrative lesion with signifi-
cant mass effect and cystic/necrotic area. The anatomopathology
disclosed a glioblastoma grade IV. This case reinforces the impor-
tance of carrying a imagiologic workup in cases like this, especially
on patients with atypical presentation of psychiatric symptoms.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0179
Differential effects of MGluR5
receptor blockade on behavior,
schizophrenia-relevant gene
expression and neuronal activation
patterns from development to aging
mice
P. Gass ∗, D. Inta , A. Luoni , M.A. Riva
1 Psychiatry and Psychotherapy, Central Institute of Mental Health,
Mannheim, Germany
2 University of Milan, Center of Neuropharmacology, Milano, Italy
∗ Corresponding author.
Introduction The glutamate system is implicated both in mood
disorders and schizophrenia. Mice lacking metabotropic mGlu5
receptors (mGluR5 KO) display schizophrenia-like abnormalities.
Additionally, mGluR5 antagonists represent promising alternative
anxiolytics/antidepressants. However, the underlying age-specific
molecular/cellular mechanisms are only partially understood.
Objectives We aimed at identifying molecular alterations associ-
ated with a genetically induced mGluR5 deletion, which results in
a schizophrenia-like phenotype. Additionally, we investigated age-
specific effects of mGluR5 antagonists on emotional behaviour and
c-fos activation.
Methods For analysis of mRNA and protein levels we per-
formed Real-time RT-PCR and Western blot investigations of
brains from mGluR5 KO and wild-type mice. Additionally we
used classical behavioral tests for determining anxiety- and
depression-like changes triggered by the mGluR5 antagonist
2-Methyl-6-(phenylethynyl)pyridine (MPEP). Finally, we used pro-
filing of c-Fos expression, as marker of neuronal activity, induced
by MPEP from postnatal day 16 (P16) to adulthood (P90).
Results We found reduced expression levels of reelin, GAD65,
GAD67, parvalbumin, as well as NMDA and AMPA receptor
subunits in mGluR5 KO mice, especially in the prefrontal cor-
tex (PFC). We measured age-specific alterations in emotional
behaviour of mGluR5 KO mice, with marked increase of anxi-
ety during aging. There was a remarkably conserved activation
of the paraventricular nucleus of the hypothalamus, implicated
in stress regulation, by MPEP at all investigated ages, whereas
the extended amygdala was specifically activated in adulthood
only.
Conclusions Our animal data provide new insights into the poten-
tial role of mGluR5 in neurochemical and behavioural changes
associated with schizophrenia and mood disorders during the life-
span.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0180
Influence of personal meaning
organization and 5-HTTLPR genotype
on cortisol stress reactivity in healthy
women
A. Marini ∗, C. Turchi , E. Skrami , R. Gesuita , M. Giordani ,
B. Nardi
1 Psychiatric Unit, Department of Experimental and Clinical Medicine,
Università Politecnica delle Marche, Ancona, Italy
2 Section of Legal Medicine, Department of Biomedical Sciences and
Public Health, Polytechnic University of Marche, Ancona, Italy
3 Center of Epidemiology, Biostatistics and Medical Information
Technology, Polytechnic University of Marche, Ancona, Italy
4 Psychiatric Unit, Department of Experimental and Clinical Medicine,
Polytechnic University of Marche, Ancona, Italy
∗ Corresponding author.
Introduction Reactivity to acute psychosocial stress in the frame-
work of a physiological multidimensional pattern affects several
individual-level systems that include genetic factors and features
related to personality development. The 5-HTTLPR genotype has
been implicated in themodulation of susceptibility to environmen-
tal stimuli.
Objectives In the present study, 91 healthy young women were
investigated (i) for their reactivity to a standardized psychosocial
laboratory stressor (TSST), as measured by changes in salivary cor-
tisol; (ii) in terms of 5-httlpr genotype and (iii) in terms of their
personality profile according to the post-rationalist personal mean-
ing organizations (PMOs), which are considered as adaptive modes
of response to environmental stressors.
Methods Participants were divided into three 5-HTTLPR geno-
type groups (s/s; s/l, and l/s). The quantitative and qualitative
variables that may affect circulating cortisol were compared among
the three groups. Amultiple linear quantile regression analysis was
then performed to evaluate the effect of the personality profile, as
Outward/Inward PMO, and 5-HTTLPR genotype on themedian level
of cortisol, considered as dependent variable.
Results Comparison of the variables that may affect circulating
cortisol no significant differences. Salivary cortisol changed signif-
icantly in the course of the TSST. Reactivity to stress was affected
by personality profile and the 5-HTTLPR genotype and also by body
mass index and age.