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Page Background European Psychiatry 41S (2017) S170–S237

Available online at


25th European Congress of Psychiatry

e-Poster Walk part 2

e-Poster walk: Old-age psychiatry


Hippocampal volume recovery after

depression: Evidence from an elderly


I. Bensassi

, J. Lopez-Castroman , R. Calati , P. Courtet

Inserm U1061, Colombière Hospital, Adult Psychiatry, Montpellier,


Corresponding author.


Structural neuroimaging studies have revealed a con-

sistent pattern of volumetric reductions in both the hippocampus

and the anterior cingulate cortex (ACC) of individuals with a major

depressive episode (MDE). This study investigated hippocampal

and ACC volume differences in the elderly comparing currently

depressed individuals and individuals with a past lifetime history

of MDE versus healthy controls.


We studied non-demented individuals from a cohort

of community-dwelling people aged 65 and over (ESPRIT study).

T1-weighted magnetic resonance images were used to acquire

anatomical scans from 150 currently depressed individuals, 79

individuals with at least one past MDE, and 310 healthy controls.

We derived quantitative regional estimates of subcortical volume

of hippocampus and ACC using FreeSurfer Software (automated

method). Concerning hippocampus, we also used a manual method

of measurement. General Linear Model was used to study brain

volumes in current and past depression adjusting for gender, age,

education level, total brain volume, and anxiety disorder comor-



After adjustment, current depression was associated

with a lower left posterior hippocampal volume (


= 10.38,


= 0.001) using manual estimation of volume. No other signifi-

cant differences were observed. A positive correlation was found

between time since the last MDE and left posterior hippocampal



The finding of left posterior hippocampal volume

reduction in currently depressed individuals but not in those with

a past MDE compared to healthy controls could be related to brain

neuroplasticity. Additionally, our results suggest manual measures

to be more sensitive than automated methods.


Major depressive episode; Late life depression; Brain

imaging; Biological psychiatry; Magnetic resonance imaging

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.


Introduction to mindfulness: A pilot

exploratory study among memory

clinic attendees

C. Dolan

1 ,

, I. Bruce


, B.A. Lawlor



St. James’s Hospital, General Adult Psychiatry, Dublin, Ireland


St. James’s Hospital, Medicine for the Elderly, Dublin, Ireland


Trinity College Dublin, Old Age Psychiatry, Dublin, Ireland

Corresponding author.


Evidence from the literature suggests that group

mindfulness interventions result in improved quality of life,

less depressive symptoms and improved subjective sleep quality

among patients with memory problems

[1] .


To design and pilot a brief mindfulness intervention

for Memory Clinic attendees.


To develop a non-pharmacological low-resource interven-

tion for Memory Clinic attendees.


An introduction to mindfulness pack, designed by

author CD, includes a booklet introducing the concept of mindful-

ness, instructions for meditation exercises with an accompanying

CD. Memory clinic attendees diagnosed with subjective mem-

ory complaints or mild cognitive impairment were invited to

take part. Participants completed standardised questionnaires

pre- and post-intervention, which examined subjective mem-

ory, depression and anxiety symptoms, subjective sleep quality,

worry and mindfulness levels. Qualitative information was also



Of twenty-four participants (66.6% female, mean age

60.8 years), 14 (58.3%) completed the 6-week study. There was no

statistical difference in anxiety and depressive symptoms, quality

of life, sleep quality and worry levels pre- and post-intervention

among participants. However, 100% of participants found the

mindfulness intervention beneficial, with 64.3% (


= 9) reporting a

subjective improvement in both memory and concentration.


In this small pilot study, a brief self-guided mind-

fulness intervention was found to be acceptable to a heterogenous

group of Memory Clinic attendees.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.