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25th European Congress of Psychiatry / European Psychiatry 41S (2017) S106–S169


The present data suggest that the psychosocial stress

response is a multidimensional physiological event that is affected

by a variety of factors as diverse as 5-HTTLPR genotype, personality

profile, BMI, and age.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.


Skin conductance response to

emotional stimuli and injury location

in patients with single right

hemisphere damage

S. Álvarez


, G. Lahera

2 , 3 ,


Foundation Alicia Koplowitz Research Fellow, New York University

Child Study Center, Child Psychiatry, NY, USA


Psychiatry, University of Alcalá, Alcalá de Henares, Madrid, Spain


Cibersam, Mental Health, Madrid, Spain

Corresponding author.


Right hemisphere damage (RHD) has been related

to alterations in emotion processing. However, results regarding

physiological responses are limited and inconsistent. More

research regarding specific brain areas involved in emotional phys-

iological responses is needed.


To examine the skin conductance response (SCR) to

emotion eliciting images in patients with single RHD. To explore

the relationship between SCR and brain injury location in patients

with single RHD.


To examine the relationship between SCR and cortical and

subcortical damage in RH regarding emotional processing.


Forty-one individuals with RHD due to stroke were

assessed (mean age 68.5, SD 12.2, 51.1 males). The amplitude of

event-related SCR was registered through a biofeedback system

while observing 54 photographs from the international affective

picture system (IAPS). Emotional images were classified using

two different approaches: emotional valence (pleasant, unpleasant,

neutral) and social vs. non-social content. Brain damage location,

determined through medical records, included cortical (frontal,

parietal, temporal and occipital lobes) as well as sub-cortical (cau-

date nucleus, thalamus, lenticular nucleus, insular cortex, basal

ganglia and limbic system) structures.


Amplitude of SCR to emotional images was significantly

lower in individuals with occipital cortex injury compared to those

with damage in other brain locations (


< 0.05). These results were

consistent through all stimuli categories but non-social pictures,

which presented the same pattern though, did not reach statistical



Results show a relationship between occipital areas

in HD and SCR to emotional eliciting stimuli, suggesting occipital

right lobe involvement in physiological emotional processing.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.


The use of polygenic risk scores to

inform aetiology of mood and

psychotic disorders

J. Harrison

, S. Mistry

Cardiff University School of Medicine, MRC Centre for

Neuropsychiatric Genetics and Genomics, Cardiff, Wales, United


Corresponding author.


Polygenic risk scores (PRS) incorporate many small

geneticmarkers that are associatedwith conditions. This technique

was first used to investigate mental illnesses in 2009. Since then, it

has been widely used.


We wanted to explore how PRS have been used to the

study the aetiology of psychosis, schizophrenia, bipolar disorder

and depression.


We aimed to conduct a systematic review, identify-

ing studies that have examined associations between PRS for

bipolar disorder, schizophrenia/psychosis and depression and

psychopathology-related outcome measures.


We searched EMBASE, Medline and PsychInfo from

06/08/2009 to 14/03/2016. We hand-searched the reference lists

of related papers.


After removing duplicates, the search yielded 1043 pub-

lications. When irrelevant articles were excluded, 33 articles

remained. We found 24 studies using schizophrenia PRS, three

using bipolar PRS and nine using depression PRS. Many studies

successfully used PRS to predict case/control status. Some studies

showed associations between PRS and diagnostic sub-categories.

A range of clinical phenotypes and symptoms has been explored.

For example, specific PRS are associated with cognitive perfor-

mance in schizophrenia, psychotic symptoms in bipolar disorder,

and frequency of episodes of depression. PRS have also demon-

strated genetic overlap between mental illnesses. It was difficult

to assess the quality of some studies as not all reported sufficient

methodological detail.


PRS have enabled us to explore the polygenic archi-

tecture of mental illness and demonstrate a genetic basis for some

observed features. However, they have yet to give insights into the

biology, which underpin mental illnesses.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.


Identification of biological pathways

to Alzheimer’s disease using polygenic


J. Harrison

, E. B

aker , L. Hubbard , D. Linden , J. Williams ,

V. Escott-Price , P. Holmans

Cardiff University School of Medicine, MRC Centre for

Neuropsychiatric Genetics and Genomics, Cardiff, Wales, United


Corresponding author.


Single nucleotide polymorphisms (SNPs) contribute

small increases in risk for late-onset Alzheimer’s disease (LOAD).

LOAD SNPs cluster around genes with similar biological functions

(pathways). Polygenic risk scores (PRS) aggregate the effect of SNPs

genome-wide. However, this approachhas not beenwidely used for

SNPs within specific pathways.


We investigated whether pathway-specific PRS were

significant predictors of LOAD case/control status.


We mapped SNPs to genes within 8 pathways impli-

cated in LOAD. For our polygenic analysis, the discovery sample

comprised 13,831 LOAD cases and 29,877 controls. LOAD risk

alleles for SNPs in our 8 pathways were identified at a



value threshold of 0.5. Pathway-specific PRS were calculated in

a target sample of 3332 cases and 9832 controls. The genetic

data were pruned with



> 0.2 while retaining the SNPs most

significantly associated with AD. We tested whether pathway-

specific PRS were associated with LOAD using logistic regression,

adjusting for age, sex, country, and principal components. We

report the proportion of variance in liability explained by each



Themost strongly associated pathwayswere the immune

response (NSNPs = 9304, = 5.63







= 0.04) and hemostasis

(NSNPs = 7832,


= 5.47







= 0.015). Regulation of endocyto-

sis, hematopoietic cell lineage, cholesterol transport, clathrin and