European Psychiatry - Volume 41 - April 2017

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S162 25th European Congress of Psychiatry / European Psychiatry 41S (2017) S106–S169
e-Poster walk: Genetics & molecular neurobiology
and neuroscience in psychiatry
EW0169
Meta-analysis update of association
between dopamine transporter
SLC6A3 gene polymorphism, smoking
cessation
H. Choi
Yeungnam University, College of Pharmacy, Gyeongsan-Gyeongbuk,
Republic of Korea
The SLC6A3 gene is involved in the dopamine pathway, which
influences smoking behavior. This study was conducted to present
updated results of a meta-analysis to evaluate the association
between SLC6A3 polymorphism and smoking cessation. In total,
eight studies were assessed, and 9-repeat alleles and no 9-repeat
alleles were compared by smoking cessation outcomes. No signifi-
cant association between SLC6A3 genotype and smoking cessation
was observed for the main analysis (odds ratio = 1.128; 95% confi-
dence interval = 0.981–1.298). In conclusion, the genetic variations
in SLC6A3 are not associated with smoking cessation, which is not
consistent with the results of the previous meta-analysis.
Disclosure of interest The author has not supplied his/her decla-
ration of competing interest.
EW0170
Qualitative meta-analysis to identify
genomic variants that are correlated
with the development of
Schizophrenia
G. Chondrou ∗ . Patrinos , E.E. Tsermpini
University of Patras, Department of Pharmacy, Patras, Greece
∗ Corresponding author.
Introduction Schizophrenia is a devastating and complex dis-
ease, which occurs in approximately 1% of the general population.
Symptoms include hallucinations, delusions and patients’ social
withdrawal. Schizophrenia’s etiology remains unclear, however,
both patients’ genetic profile and environmental factors play a sig-
nificant role.
Objectives Our study’s primary objective was to identify
genetic variants related with schizophrenia’s development in
non-Caucasians populations and to explore whether these poly-
morphisms can be also found in schizophrenia patients of
Caucasian origin.
Methods To achieve that, we screened Science Direct and
PubMed medical literature databases to identify research articles
correlating genes and variantswith the development of schizophre-
nia. Next step was the categorization of studies according to
samples’ origin and the identification of genomic variants that are
correlatedwith schizophrenia (P < 0.001) but have never been stud-
ied in Caucasian populations.
Results In total, 108 and 47 studies, in non-Caucasian and Cau-
casian populations respectively, were identified, in which 157
(P < 0.05) and18 (P < 0.001) variantswere associatedwith the devel-
opment of the disease in non-Caucasian populations.
Conclusions From our qualitative meta-analysis 18 variants that
were correlated with schizophrenia’s etiology were identified
(P < 0.001), which will be further investigated in a multi-cultural
Caucasian cohort.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0171
Potential values and risks of
biomarker use in differential
diagnosis of neurocognitive disorders
N. De Uribe-viloria ∗, M. De Lera Alfonso ,
L. Rodriguez Fernandez , G. Zapico Aldea ,
C. Laserna Del Gallego , A. Alonso Sanchez , A. Alvarez Astorga ,
H. De La Red Gallego , M. De Lorenzo Calzon ,
M. Gomez Garcia , G. Medina Ojeda ,
F. De Uribe Ladron De Cegama
1 Hospital Clinico Universitario De Valladolid, Psychiatry, Valladolid,
Spain
2 Hospital Clinico Universitario De Valladolid, Neurology, Valladolid,
Spain
3 Hospital Clinico Universitario De Valladolid, Internal Medicine,
Valladolid, Spain
4 Hospital Clinico Universitario De Valladolid, Family Medicine And
Community Health, Valladolid, Spain
∗ Corresponding author
Introduction Neurocognitive disorders are the only psychiatric
disorders which underlying pathogeny can potentially be deter-
mined. This has important implications, for it makes possible the
use of biomarkers in order to gain better diagnosis, and opens a
door to more accurate treatments. Nonetheless, as biomarkers are
not exclusive of a single disorder, the lengths of its utility are still
unknown.
Objectives and aims To understand the values and limitations of
biomarkers in differential diagnosis of dementias.
Methods We present three cases followed in the Neurology ward
of our hospital, in which they were admitted for diagnosis and
treatment of a subacute form of dementia. Medical history, core
symptoms, screening tests for cognitive impairment, MRI, EEG and
biomarkers in cerebrospinal fluid were used for diagnosis.
Results Two cases had consistent clinical features and comple-
mentary explorations, and they were respectively diagnosed as
Creutzfeldt-Jakob Disease and Lewy Body Dementia; however, the
last case showed contradictory results between clinic and com-
plementary explorations, particularly 14-3-3 protein, which was
positive and led to the initial diagnosis as Creutzfeldt-JakobDisease,
which was proven wrong once necropsy was practiced.
Conclusions Although complementary explorations, and
biomarkers in particular, are of invaluable utility in the accu-
rate diagnosis of multiple psychiatric diseases, they must always
be considered within a context given by biography and clinical fea-
tures, because, when failing to do so, they can lead to misdiagnosis
and delay of correct treatment.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0172
Spatio-temporal perception and
boundaries of self: Evaluation of
peripersonal space in schizotypy traits
G. Di Cosmo ∗, F. Fiori , F. Ferri , A. Salone , M. Corbo ,
M. Costantini , G. Martinotti , M. di Giannantonio , L. Marzetti
1 University “G. D’ Annunzio” Chieti, Neuroscience, Imaging and
Clinical sciences, Chieti, Italy
2 University of Essex, Centre for Brain Science, Department of
Psychology, Colchester, United Kingdom
∗ Corresponding author.
Introduction The peripersonal space is described as that area
within the boundary between self and non-self. An accurate
judgment of peripersonal space boundaries may depend on the
capacity to create an organized and structured mental represen-
tation that integrates signals from different sensory modalities and