European Psychiatry - Volume 41 - April 2017

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25th European Congress of Psychiatry / European Psychiatry 41S (2017) S170–S237 S205
EW0291
FKBP5 modulates the effects of
nicotine on hpa axis activity in
females
A. Koopmann∗, F. Kiefer
Department of Addictive Behaviour and Addiction Medicine
Mannheim, Central Institute of Mental health, Mannheim, Germany
∗ Corresponding author.
Background FK506 binding protein 51 is a modulator of the
hypothalamic-pituitary-adrenal axis activity. Its function is modu-
lated by the single nucleotide polymorphism rs 1360780. Females
often use smoking to cope with stress. The aim of this study was
to investigate if the influence of nicotine consumption on cortisol
plasma levels is modified by the polymorphism of rs 1360780 in
females.
Methods Two hundred and ninety-six female smokers were
genotyped for the SNP rs1360780 of FKBP5 protein. Cortisol plasma
concentrations were measured in blood plasma drawn three hours
after smoking. Severity of tobacco addiction was assessed based on
the Fagerström Test for Nicotine Dependence (FTND).
Results Thirty-six participants were TT-homozygotes and 260
were C allele carriers. In TT homozygotes, we found a significant
negative correlation between the FTND sum score and the corti-
sol plasma concentrations. In a linear regression analysis, the FTND
sum score accounts for 12.4% of the variance of cortisol plasma lev-
els. By contrast, we could not find such an association in C allele
carriers.
Conclusions Our results suggest that nicotine is an important con-
founder in themodulation of HPA axis activity by FKBP5. In the light
of these findings, future studies on FKBP5 should include nicotine
consumption as a confounder.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0292
Influence of impulsivity during
decision-making in regular cannabis
users
V. Laprevote ∗, A.L. Devin , B. Blanc , R. Schwan
1 Psychiatric University Clinic of Grand Nancy, CPN Nancy, Laxou,
France
2 Université de Lorraine, EPSaM- EA4360 APEMAC, Metz, France
3 Addiction Medicine Department, CH Jury, Metz, France
∗ Corresponding author.
Introduction Regular cannabis use is associated with cognitive
impairments, including impaired decisionmakingmeasured by the
Iowa Gambling Task. The question remainswhether the impulsivity
measured in regular cannabis users may participate to impaired
decisionmaking. Interestingly, the Cambridge Gambling Task (CGT)
is a computerized gambling task allows to differentiate risk taking
and impulsivity when making a decision.
Aims This study aims at separately exploring the impact of reg-
ular cannabis use on risk taking and impulsivity during decision
making process.
Objectives To do so, we compared the performance of regular
cannabis users and healthy controls during the CGT.
Methods Forty-three regular cannabis users (> 7 units/week)
with a cannabis use disorder (CUD), 8 non-CUD regular cannabis
users and 30 healthy controls were recruited. Decision-making was
assessed using the CGT. The following outcomes were considered:
Delay aversion score, Overall proportion bet, quality of decision
making, risk taking and risk adjustment.
Results The analysis on delay aversion score showed a group
effect (F = 3.839, P = 0.026) but no effect on other CGT variables.
This effect was explained by the fact that cannabis CUD users had
a higher delay aversion score than healthy controls and non-CUD
cannabis users.
Conclusions In this study, CUD cannabis users had an increased
impulsivity but no increase of risk taking and quality of decision-
making. Future work should include the CGT with a clinical scale
to evaluate impulsivity and a motor inhibition task to understand
if the impairment observed relates to cognitive or motor abilities.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0293
Psychosocial functioning in injured
and non-injured athletes with
symptoms of exercise addiction
M. Lichtenstein ∗, R.Ø. Nielsen , C. Gudex , A.B. Bojesen ,
C.J. Hinze , U. Jørgensen
1 Department of Psychology, University of Southern Denmark,
Odense, Denmark
2 Sport Science, Aarhus University, Department of Public Health,
Aarhus, Denmark
3 University of Southern Denmark, Department of Clinical Research,
Odense, Denmark
4 Mental Health Services, Region of Southern Denmark, Odense,
Denmark
5 Reseach Unit for Telepsychiatry and E-mental Health, Odense,
Denmark
6 Orthopaedic Research Unit, Odense University Hospital, Odense,
Denmark
∗ Corresponding author.
Introduction Exercise addiction is characterized by compulsive
and excessive exercise patterns that eventually can lead to muscu-
loskeletal injury. While exercise leads to increased self-esteem and
is a useful tool for emotional regulation, the level of psychosocial
distress may be negatively affected by such injuries.
Objectives The prevalence proportions of post-injury depression
and emotional stress in athletes with exercise addiction have not
previously been explored and compared to non-addicted athletes.
Aims We wanted to test the hypothesis that athletes with addic-
tion profiles react to injury with higher levels of emotional and
social distress compared to athletes without addiction.
Methods A cross-sectional survey was employed and a total of
1167 athletes (673 with diagnosed musculoskeletal injuries and
494 without present injury) responded to the following question-
naires: The Exercise Addiction Inventory, The Major Depression
Inventory, The Perceived Stress Scale and EQ-5D to assess quality
of life.
Results We found that 26% of the injured athletes with exercise
addiction had symptoms of major depression and 53% reported
emotional distress. These proportions were significantly greater
compared with the injured non-addicted athletes where 11% had
symptoms of major depression and 28% reported stress. Quality of
life was also significantly reduced in the addiction group.
Conclusions Injured athletes with exercise addiction report more
post-injury psychosocial distress compared with injured non-
addicted exercisers. Future trials need to investigate the effect of
emotional assessment and support as a complement intervention
to somatic injury treatment. Injured athletes should be examined
for exercise addiction as they are at risk of depression.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.