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25th European Congress of Psychiatry / European Psychiatry 41S (2017) S170–S237



These preliminaryfindings suggest that platelet fatty

acids may be possible biological markers to improve the diagnosis

of BD.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.


Bipolar disorder in epilepsy

N. Sivakova

1 ,

, G . M


2 , L. L




St. Petersburg Psychoneurological Research Institute named after

V.M. Bekhterev, the Department of epilepsy, Saint Petersburg, Russia


St. Petersburg Psychoneurological Research Institute named after

V.M. Bekhterev, the Department psychopharmacology and

pharmacotherapy of patients with resistant conditions with a group

of endocrinology Psychiatry, Saint Petersburg, Russia

Corresponding author.


Bipolar disorder (BD) and epilepsy are the chronic

recurrent diseases with several similarities in pathogenic mecha-

nisms. There are high prevalence of comorbidity between affective

disorders and epilepsy. However, most recent studies focused on

association epilepsy with depression, while lack of scientific data

about relationship between epilepsy and BD.


This study examined the frequency of bipolar disorder

in epileptic patients.


To improve the diagnostic tool for BD in epileptic patients.

Materials and methods

We observed 50 patients with epilepsy

(PE). In this study, the symptoms of BD were measured by the

Hypomania Checklist-32 (HCL-32).


The mean age of the entire cohort was 40 (SD = 19.2)

years. The proportion of females were 62%. The mean score using

HCL-32 were 11.1 (SD = 4.5, range: 3–20) with 17 (34%) scoring

above 14, the cut-off points for the basic version of the HCL-32.

Among of high score subgroup there were 6 men and 11 women,

maximum age was 74 and minimum 19, the mean age of the sub-

group were 37 years. The patients 8 out of 17 (47%) received a

score of 20 or more (maximum of 37) on the bipolar index that

corresponds to

20% probability BD.


The results of the study observed a high prevalence of

BD in PE. Future research addressing (1) using of psychiatric exam-

ination instruments to assess affective symptoms among PE and

(2) treatment management of affective symptoms by antiepilep-

tic drugs might result in better treatment outcomes among patient

with comorbidities of BD and PE.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.


Early and late onset bipolar disorders

in older adults

N. Smaoui


, L. Zouari


, N. Charfi

2 ,

, M. Maâlej-Bouali



N. Zouari


, J. Ben Thabet


, M. Maâlej



Hedi Chaker University Hospital, Department of Psychiatry, Hedi

Chaker University Hospital, sfax, Tunisia


Hedi Chaker University Hospital, Department of Psychiatry C, Hedi

Chaker University Hospital, sfax, Tunisia

Corresponding author.


Age of onset of illness may be useful in explaining

the heterogeneity among older bipolar patients.


To examine the relationship of age of onset with clin-

ical, demographic and behavioral variables, in older patients with

bipolar disorder.


This was a cross-sectional, descriptive and analytical

study, including 24 patients suffering from bipolar disorders, aged

65 years or more and followed-up in outpatient psychiatry unit

at Hedi Chaker university hospital in Sfax in Tunisia. We used a

standardized questionnaire including socio-demographic, behav-

ioral and clinical data. Age of onset was split at age 40 years into

early-onset (< 40 years;


= 12) and late-onset (

40 years;


= 12)



The mean age for the entire sample was 68.95 years.

The mean age of onset was 39.95 years. The majority (60%) of

patients were diagnosedwith bipolar I. Fewmeaningful differences

emerged between early-onset and late-onset groups, except that

tobacco use was significantly higher in the late-onset group (66.6%

vs. 16.6%;


= 0.027). No significant differences between the early-

onset and late-onset groups were seen on demographic variables,

family history and number of medical diagnoses or presence of

psychotic features.


Our study found few meaningful behavioral differ-

ences between early versus late age at onset in older adults with

bipolar disorder.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.


Cultural variations in bipolar

disorders in non-clinical samples

H. Aldos , H. Merey , A. Soliman

Qatar University, Social Sciences Department, Doha, Qatar

Corresponding author.


The prevalence of bipolar disorder (BD) is con-

tinuously increasing worldwide. Based on pathophysiological

prospective, BD is related to the change in neural circuitry involved

in the regulation of emotion. Since there is a cultural variation in

emotion expression, it is expected that BD is subject to cultural

differences. The literature suggests that the prevalence of BD is

influenced by gender, region and ethnicity.


Exploring the pervasiveness of BD in the Arab cultures.

Aims – exploring the pervasiveness of BD in six different but related

Arab cultures;

– examining the gender differences in BD in the Arab cultural con-



This study used 327 freshmen university students (42%

males and 58% females) from six different Arab universities and

administered theMoodDisorder Questionnaire (MDQ). The validity

and reliability of the MDQ was measured on 220 Qatari university



The results showed that BD was positively related to

age and that males exhibited greater BD symptoms than females.

The MDQ scores varied between the Arab subcultures. Sudanese

subjects scored the highest on the MDQ, and therefore showed

the highest numbers of BD characteristics, followed by Palestini-

ans, Egyptians, Yemenis, Qataris, Jordanians and Tunisians. The

Tunisians exhibited the lowest BD symptoms among six Arab cul-



The findings suggested that it is arguable that BD

is sensitive to cultural variations in the Arab world, with males

showing a higher number of bipolar symptoms. It is arguable that

BD is influenced by cultural openness and socioeconomic status.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.