European Psychiatry - Volume 41 - April 2017

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S246 25th European Congress of Psychiatry / European Psychiatry 41S (2017) S238–S302
EW0411
Substance use disorder in the
offspring of antenatally depressed
mothers in the Northern Finland 1966
birth cohort: Relationship to parental
history of severe mental disorder
P. Mäki ∗, T. Taka-Eilola , J. Veijola
1 University of Oulu and Oulu University Hospital, Psychiatry,
University of Oulu, Finland
2 University of Oulu, Psychiatry, University of Oulu, Finland
∗ Corresponding author.
Introduction Maternal depression during pregnancy is common.
However, reports of the adult offspring with maternal antenatal
depression are scarce.
Objectives Our aimwas to study whether offspring of antenatally
depressed mothers have increased risk for substance use disorder
when taking account parental mental disorder.
Methods In the Northern Finland 1966 Birth Cohort, the moth-
ers of 12,058 children were asked at the antenatal clinic if they
felt depressed. The offspring were followed for over 40 years. Sub-
stance use disorders were detected using the Finnish Care Register
for Health Care, which was also used for identifying severe mental
disorders in the parents till 1984.
Results Of the mothers, 14% had rated themselves as depressed
during pregnancy. Of the parents, 10% had had a hospital-treated
mental disorder. The risk for substance use disorder was slightly
increased in the offspring of antenatally depressed mothers (crude
OR 1.6; 95% CI 1.2–2.1), when compared with the cohort members
without maternal antenatal depression. The risk for substance use
disorder was higher in the offspring with both maternal antena-
tal depression and parental mental disorder (2.8; 1.7–4.7) than in
those withmaternal depression but without parental mental disor-
der (1.4; 1.1–2.0) or those without maternal depression and with
parental mental disorder (1.5; 1.1–2.2). The reference group was
cohort members without maternal antenatal depression and with-
out parental mental disorder. The association remained significant
after adjustment
Conclusions Offspring with both maternal depression during
pregnancy and parental severe mental disorder have elevated risk
for substance use disorder.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
Reference
[1] Mäki P, et al. Am J. Psychiatry 2010.
EW0412
Does substance abuse mediate or
moderate the relationship between
childhood trauma and the experience
of persecutory delusions in people
with schizophrenia in South Africa?
S. Mall
University of the Witwatersrand, Division of Epidemiology and
Biostatistics, School of Public Health, Faculty of Health Sciences,
Johannesburg, South Africa
Background Persecutory delusions, a key symptom of schizo-
phrenia, may be associated with the experience of early childhood
trauma as well as with cannabis dependence. Little research has,
however, addressed these associations in people with schizophre-
nia on the African continent. We examined if persecutory
delusions were significantly associated with childhood trauma
in people with schizophrenia from South Africa, and we investi-
gated whether cannabis dependence mediates or moderates this
association.
Methods Seven hundred and twenty-eight people with schizo-
phrenia completed several scales including the childhood trauma
questionnaire (CTQ) which captures several domains of child-
hood trauma. Logistic regression and structural equationmodelling
methods were employed to examine the relationship between per-
secutory delusions and specific experiences of childhood trauma,
and to determine if cannabis dependence is mediating or moderat-
ing this relationship.
Results Preliminary results suggest that of the various childhood
traumas, the strongest predictor of the presence of persecutory
delusions was emotional abuse [OR: 1.02 (0.94–1.08)]. There was
no evidence of mediation by cannabis dependence. However, all
experiences of childhood trauma, measured by the CTQ (with the
exception of physical neglect) interacted with cannabis depen-
dence to increase the risk of the onset of persecutory delusions
(P < 0.001).
Conclusions These results are consistent with previous data in
demonstrating that both childhood trauma and cannabis depen-
dence are associated with persecutory delusions in schizophrenia.
These findings suggest that it is important to examine the role of
early childhood trauma as well as substance use in predicting the
onset of psychosis to inform treatment strategies.
Disclosure of interest The author has not supplied his/her decla-
ration of competing interest.
EW0413
Increased prevalence of major
depressive disorder in patients who
get admitted with atrial fibrillation
with worse outcomes
Z. Mansuri ∗, S. Patel , P. Patel , O. Jayeola , A. Das , J. Shah ,
M.H. Gul , A. Ganti , K. Karnik , R. Patel
1 Texas Tech University Health Sciences Center Permian Basin
Campus, Psychiatry, Odessa, USA
2 Icahn School of Medicine at Mount Sinai, Public Health, New York,
USA
3 Windsor University School of Medicine, Public Health, Monee, USA
4 Drexel University School of Public Health, Public Health,
Philadephia, USA
5 Florida Hospital, Internal Medicine, Orlando, USA
6 Pramukhswami Medical College, Internal Medicine, Karamsad, India
7 St. Louis University Hospital, Nephrology, St. Louis, USA
8 Suburban Medical Center, Internal Medicine, Schaumburg, USA
9 Children’s Hospital of San Antonio, Public Health, San Antonio, USA
10 Acardia University, Public Health, Glenside, USA
∗ Corresponding author.
Objective To determine trends and impact on outcomes of atrial
fibrillation (AF) in patients with pre-existing major depressive dis-
order(MDD).
Background While post-AF MDD has been extensively studied,
contemporary studies including temporal trends on impact of pre-
AF MDD on AF and post-AF outcomes are lacking.
Methods We used Nationwide Inpatient Sample (NIS) from
Healthcare Cost and Utilization Project (HCUP) from 2002 to 2012.
We identified AF and MDD as primary and secondary diagnosis
respectively using validated International Classification of Dis-
eases, 9th Revision, and Clinical Modification (ICD9CM) codes, and
used Cochrane-Armitage trend test and multivariate regression to
generate adjusted odds ratios (aOR).
Results We analyzed total of 3,887,827 AF hospital admissions
from 2002 to 2012 of which 6.78% had MDD. Proportion of
hospitalizations with MDD increased from 4.93% to 14.19% ( P-
trend < 0.001). Utilization of atrial cardioversion was lower in
patients with MDD (34.37% vs. 40.52%, P < 0.001). In-hospital mor-
tality was significantly lower in patients with MDD (aOR0.749; 95%
CI 0.664–0.846; P < 0.001) but discharge to specialty carewas higher