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25th European Congress of Psychiatry / European Psychiatry 41S (2017) S238–S302


We conducted a prospective study with a sample size

of 23 patients (10 male), who met the criteria of treatment-

resistant depression according to ICD–10 and gave their informed

consent for ECT treatment. Before and after ECT, the following

investigations have been performed: Beck depression inven-

tory (BDI), Montgomery-Asberg depression rating scale (MADRS),

Mehrfachwahl-Wortschatz-Intelligenztest (MWT-B), trail making

test (TMT) A and B, stroop-test, mini mental state examination

(MMSE) and the German version of the California verbal learning

test (MGT).


After ECT treatment, we found highly significant changes

of depression-scales BDI (


= 0.028) and MADR-Scale (


= 0.001).

IQ as measured by the MWT-B (


= 0.851), executive functions as

measured by trail making test A (


= 0.568) and B (


= 0.372) and

stroop-test, memory functions as measured by the MGT (


= 0.565)

( Figure 1 ) a

ndMMSE (


= 0.678) did not differ significantly after ECT



There were no significant differences in cognitive

function before and after ECT treatment. To confirm these findings,

it would be necessary to perform larger studies.

Figure 1

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.


Vascular disease and trajectories of

late-life major depressive disorder in

secondary psychiatric care

K. Musliner

1 ,

, T. Laursen


, T. Munk-Olsen


, X. Liu



P. Mortensen


, P. Zandi


, W. Eaton



Centre for Register-based Research, Economics and Business

Economics, Århus V, Denmark


Johns Hopkins University, Mental Health, Baltimore, USA

Corresponding author.


To examine 5 years trajectories of secondary-treated

late-life major depressive disorder (MDD), and evaluate whether

pre-existing cerebrovascular disease and related risk factors are

associated with more severe trajectories of late-life MDD.


Data were obtained from Danish registers. The sample

included 11,184 adults

60 at indexMDD diagnosis. Trajectories of

in or outpatient contact at psychiatric hospitals for MDD over the

5 years period following index MDD diagnosis were modeled using

latent class growth analysis. Risk factors included cerebrovascular

disease, cardiovascular disease, hypertension, diabetes, and vascu-

lar dementia defined based on hospital diagnoses and prescription

medications, demographic characteristics and characteristics of the

index MDD diagnosis.


The final model included classes with consistently low

(66%), high decreasing (19%), consistently high (9%) and moderate

fluctuating (6%) probabilities of contact at a psychiatric hospi-

tal for MDD during the 5 year period following the index MDD


( Fig. 1 ).

Older age, greater severity, inpatient treatment

and > 12 antidepressant prescriptions within 5 years of the index

MDD diagnosis predicted membership in more severe trajectory

classes. Cerebrovascular disease and related risk factors were not

associated with trajectory class membership.


A substantial proportion (34%) of individuals diag-

nosed with MDD in late-life require specialized psychiatric

treatment for extended periods of time. We found no evidence

that cerebrovascular disease or related risk factors predicted course

trajectories in secondary-treated late-life MDD.

Fig. 1

Trajectories of late-life MDD.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.


Cognition in mild and moderate


P. Neˇsovi´c

1 ,

, M. Simonovi´c



Medical faculty in Nish, psychiatry, Niˇs, Serbia


Clinical centar Nis, Clinic for protection of mental health, The

Faculty of Medicine, University of Nis, psychiatry, Niˇs, Serbia

Corresponding author.


It is known that there is a cognitive decline in major

depressive disorder. Most studies were performed on patients

whose sum on a Montgomery and Asberg depression rating scale

was greater than 30.


In our work, we concentrated on mild and moderate

depression, MADRS > 30 was not criteria. Patients included were

diagnosed with mild to moderate depressive episode.


To determine how depressive episodes affect cognition.


We included 30 patients diagnosed at the clinic for psy-

chiatry in Nis. We covered the age group between 20 and 40 years,

regardless of the gender and educational level. For the assessment

of cognition, we used digital symbol substitution test (DSST), Rey

audio verbal learning test (RAVLT), trail making test (TMT), stroop

color naming test (Stroop), and patients were evaluatedwithMont-

gomery and Asberg depression rating scale (MADRS). Tests were

conducted on the first visit to a psychiatrist. Patients were com-

pared with the results of the healthy population with the same

characteristics, and in the same period (August 2016). Mean values

were compared and groups were compared by Student’s t-test.


There was a statistically significant difference in all of the

tests, and all of the parts of tests conducted on the patients and the

control group.