European Psychiatry - Volume 41 - April 2017

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S242 25th European Congress of Psychiatry / European Psychiatry 41S (2017) S238–S302
Methods We conducted a prospective study with a sample size
of 23 patients (10 male), who met the criteria of treatment-
resistant depression according to ICD–10 and gave their informed
consent for ECT treatment. Before and after ECT, the following
investigations have been performed: Beck depression inven-
tory (BDI), Montgomery-Asberg depression rating scale (MADRS),
Mehrfachwahl-Wortschatz-Intelligenztest (MWT-B), trail making
test (TMT) A and B, stroop-test, mini mental state examination
(MMSE) and the German version of the California verbal learning
test (MGT).
Results After ECT treatment, we found highly significant changes
of depression-scales BDI (P = 0.028) and MADR-Scale (P = 0.001).
IQ as measured by the MWT-B (P = 0.851), executive functions as
measured by trail making test A (P = 0.568) and B (P = 0.372) and
stroop-test, memory functions as measured by the MGT (P = 0.565)
ndMMSE (P = 0.678) did not differ significantly after ECT
treatment.
Conclusion There were no significant differences in cognitive
function before and after ECT treatment. To confirm these findings,
it would be necessary to perform larger studies.
Figure 1
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0400
Vascular disease and trajectories of
late-life major depressive disorder in
secondary psychiatric care
K. Musliner ∗, T. Laursen , T. Munk-Olsen , X. Liu ,
P. Mortensen , P. Zandi , W. Eaton
1 Centre for Register-based Research, Economics and Business
Economics, Århus V, Denmark
2 Johns Hopkins University, Mental Health, Baltimore, USA
∗ Corresponding author.
Objectives To examine 5 years trajectories of secondary-treated
late-life major depressive disorder (MDD), and evaluate whether
pre-existing cerebrovascular disease and related risk factors are
associated with more severe trajectories of late-life MDD.
Methods Data were obtained from Danish registers. The sample
included 11,184 adults ≥ 60 at indexMDD diagnosis. Trajectories of
in or outpatient contact at psychiatric hospitals for MDD over the
5 years period following index MDD diagnosis were modeled using
latent class growth analysis. Risk factors included cerebrovascular
disease, cardiovascular disease, hypertension, diabetes, and vascu-
lar dementia defined based on hospital diagnoses and prescription
medications, demographic characteristics and characteristics of the
index MDD diagnosis.
Results The final model included classes with consistently low
(66%), high decreasing (19%), consistently high (9%) and moderate
fluctuating (6%) probabilities of contact at a psychiatric hospi-
tal for MDD during the 5 year period following the index MDD
diagnosis Older age, greater severity, inpatient treatment
and > 12 antidepressant prescriptions within 5 years of the index
MDD diagnosis predicted membership in more severe trajectory
classes. Cerebrovascular disease and related risk factors were not
associated with trajectory class membership.
Conclusions A substantial proportion (34%) of individuals diag-
nosed with MDD in late-life require specialized psychiatric
treatment for extended periods of time. We found no evidence
that cerebrovascular disease or related risk factors predicted course
trajectories in secondary-treated late-life MDD.
Fig. 1 Trajectories of late-life MDD.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW0401
Cognition in mild and moderate
depression
P. Neˇsovi´c ∗, M. Simonovi´c
1 Medical faculty in Nish, psychiatry, Niˇs, Serbia
2 Clinical centar Nis, Clinic for protection of mental health, The
Faculty of Medicine, University of Nis, psychiatry, Niˇs, Serbia
∗ Corresponding author.
Introduction It is known that there is a cognitive decline in major
depressive disorder. Most studies were performed on patients
whose sum on a Montgomery and Asberg depression rating scale
was greater than 30.
Objectives In our work, we concentrated on mild and moderate
depression, MADRS > 30 was not criteria. Patients included were
diagnosed with mild to moderate depressive episode.
Aims To determine how depressive episodes affect cognition.
Methods We included 30 patients diagnosed at the clinic for psy-
chiatry in Nis. We covered the age group between 20 and 40 years,
regardless of the gender and educational level. For the assessment
of cognition, we used digital symbol substitution test (DSST), Rey
audio verbal learning test (RAVLT), trail making test (TMT), stroop
color naming test (Stroop), and patients were evaluatedwithMont-
gomery and Asberg depression rating scale (MADRS). Tests were
conducted on the first visit to a psychiatrist. Patients were com-
pared with the results of the healthy population with the same
characteristics, and in the same period (August 2016). Mean values
were compared and groups were compared by Student’s t-test.
Results There was a statistically significant difference in all of the
tests, and all of the parts of tests conducted on the patients and the
control group.