European Psychiatry - Volume 41 - April 2017

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S470 25th European Congress of Psychiatry / European Psychiatry 41S (2017) S465–S520
part of the assessment of patients with any unexplained acute psy-
chosis to detect this potentially curable disease. In this way, this
article analyzes the psychiatric, physical and laboratory findings
associated with hyperthyroidism and treatment.
Objectives To report a case of psychosis in a patient with
endocrine disease.
Methods Clinical records. Research on PubMed and Medscape
using the Mesh Terms “hyperthyroidism”, “psychosis” and “thyroid
and psychiatric manifestations”.
Results We present the case of a male patient, previously fol-
lowed on our ambulatory psychiatric service for drug-induced
psychosis. He was hospitalized due to psychotic symptoms,
without substance abuse. Inpatient evaluation diagnosed hyper-
thyroidism. The patient did not present any somatic changes,
except for psychosis. The patient was effectively treated with
antipsychotics. He was referred to further evaluation and started
antithyroid therapy.
Conclusions Thyroid disease should be considered in the differ-
ential diagnosis of a broad spectrum of psychiatric symptoms.
Psychosis is a rare complication of hyperthyroidism, ranging
between 1–20%. The typical psychosis is reported to simulate
manic-depressive psychosis. This association reinforces the need of
a careful clinical evaluation in patients presenting with psychosis.
Such psychiatric symptoms remit successfully with concomitant
administration of antipsychotics and normalization of thyroid lev-
els.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV0205
Alcohol use and bipolar disorder
comorbidity: Synthesis and
perspectives
A. Dahdouh ∗ emaoune Tremey amalin
V. Flaudias e Chazeron . Llorca Brousse
1 University of Oran, Departement of Psychiatry, Oran, Algeria
2 University of Algiers, Departement of Psychiatry, Algiers, Algeria
3 University Hospital of Clermont Ferrand, Departement of
psychiatry, Clermont Ferrand, France
∗ Corresponding author.
Objective Alcohol use disorders and bipolar disorder commonly
co-occur and both are associated with more pejorative outcomes,
thus constituting a major public health problem. We undertook
this synthetic review to provide an update on this issue in order to
clarify the nature of the relationship between the two disorders,
improve clinical outcomes, prevent complications and therefore
optimize management of patients.
Methods We conducted an electronic search by keywords in
databases MEDLINE, EMBASE, PsychINFO, published in English and
French from January1985 to December 2015.
Results The AUD prevalence is important among BD patients in
whom the effects of alcohol are more severe. However, in terms
of screening, it appears that the comorbidity is not systematically
sought. The concept of co-occurrence finds its clinical interest in the
development of specific screening and therapeutic strategies. To
date, there are only few recommendations about the management
of dual diagnosis and the majority of them support “integrated”
approaches.
Conclusions Recommendations should emphasize this strong
co-occurrence and promote systematic screening and offered inte-
grated cares.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV0206
Prevalence of psychiatric
comorbidities in epilepsy
N. Charfi ∗, S. Daoud , N. Farhat , M. Maâlej Bouali , L. Zouari ,
N. Zouari , J. Ben Thabet , M. Damak , C. Mhiri , M. Maalej
1 Hedi chaker Hospital, Psychiatry, Sfax, Tunisia
2 Habib Bourguiba Hospital, Neurology, Sfax, Tunisia
∗ Corresponding author.
Introduction Epilepsy is a chronic disease defined as a brain
disorder, characterized by a predisposition to present seizures, gen-
erating cognitive, psychological, and social consequences.
Objective To determine the prevalence of psychiatric comorbid
disorders in patients with epilepsy (PWEs) and its associated fac-
tors.
Methods We conducted a cross-sectional study involving 30
PWEs who were treated in the neurology department of Habib
Bourguiba Hospital in Sfax, Tunisia. We used the Mini International
Neuropsychiatric Interview for the diagnosis of Axis I psychiatric
disorders.
Results The half of patients had psychiatric comorbidities: 4 had
major depressive disorder (MDD), 2 had MDD with generalized
anxiety disorder, 4 had MDD with social phobia, 1 had bipolar dis-
order type I, 1 had panic disorder, 1 had agoraphobia and 2 had
generalized anxiety disorder.
Twenty-five PWEs had seizure-onset below30 years old and among
them, 40% had psychiatric comorbidities. Among patients who had
seizure-onset above 30 years old, none had psychiatric comor-
bidities. Psychiatric comorbidities were found in 71.5% of patients
with seizure frequency >2 per year. Psychiatric comorbidities were
more common in patients with generalized seizures compared to
whomwith partial seizures (53% versus 45%). It was alsomore com-
mon in patients treated with polytherapy compared to whomwith
monotherapy (64% versus 37.5%).
Conclusion The prevalence of psychiatric comorbidities is rela-
tively high among PWEs. The most frequent diagnoses found were
mood and anxiety disorders. It is very important to identify them
and treat them to enhance seizure control.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV0207
Cancer, depression symptoms and
quality of life: The role of creativity
L. Delpech ∗, F. Sordes , J.L. Sudres
1 CERPPS/LORDAT, Psychopathology, Toulouse, France
2 CERPPS, Psychologie de la santé, Toulouse, France
3 CERPPS, Psychopathologie, Toulouse, France
∗ Corresponding author.
The diagnosis of cancer is associated with the occurrence of psy-
chopathological symptoms, which cause even more difficulties to
patients. Scientific research demonstrates that creativity could help
increase the general population’s quality of life and regulate their
negative emotions, but only a few studies are available on the link
between creativity and the regulation of patients’ respective expe-
rience. This study aims at (1) measuring the impact of creativity on
the patient’s level of depression andquality of life and (2) evaluating
the psychopathological profile of the creative person. Thirty-five
subjects undergoing chemotherapy treatment (age: 61 + 11) took
part in this study. The experimental protocol is composed of cre-
ativity, depression and QoL tests. The results show that creativity is
negatively correlatedwith depression level and positivelywith QoL
(r =−45; P = <.05 and r=.54; P = <.01 respectively). The linear regres-
sions show that creativity is a variable, which predicts a high QoL
(F = 13.83; P=.001). Also, 29.5% of the QoL variability is explained
by creativity. A cluster analysis sorted out three different groups: