European Psychiatry - Volume 41

S478

25th European Congress of Psychiatry / European Psychiatry 41S (2017) S465–S520

Table 3

Historical data about age of drug use in both groups.

Table 4

Severity Scores for both groups of study.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2017.01.558

EV0229

GERD is associated with the outcome

of MDD treatment

K. Mati´c

1 ,

∗

, I. ˇSimunovi´c Filipˇci´c

, ˇZ. Baji´c

, I. Filipˇci´c

Psychiatric hospital Sveti Ivan, psychiatric hospital Sveti Ivan,

Zagreb, Croatia

University hospital center Zagreb, department of psychological

medicine, Zagreb, Croatia

Biometrika healthcare research, Zagreb, Croatia

∗

Corresponding author.

Introduction

Gastroesophageal reflux disease (GERD) is more

prevalent among patients with major depressive disorder (MDD)

than in general population, and vice versa. Bidirectional association

of GERD and MDD is well documented. Although protective effect

for gastric symptoms has been indicated for several antidepressants

like trazodone, citalopram, fluoxetine, mirtazapine or fluvoxam-

ine, these findings are sometimes contradictory. Similar may be

claimed for antidepressive effect of some proton pump inhibitors.

We decided to examine the association of GERDwith the long-term

efficacy of MDD treatment.

Objective

To examine the association of GERD and efficacy of

MDD treatment.

Methods

This nested cross-sectional study was done during

2016 at Psychiatric hospital Sveti Ivan, Zagreb, Croatia on the

sample of 1008 psychiatric patients. Key outcome was the number

of psychiatric rehospitalizations since the first diagnosis of MDD.

Predictor was patient-self-declared diagnosis of GERD. Covariates

controlled by multivariate analysis of covariance were sex, age,

duration of MDD in years, education, marital status, number

of household members, work status, clinical global impression

scale–severity of MDD at diagnosis, treatment with tricyclic antide-

pressants (TCA), selective serotonin reuptake inhbitors (SSRI),

serotonin-norephinephrine reuptake inhibitors (SNRI), noradren-

ergic and specific serotonergic (NaSSA) and antipsychotics.

Results

MDD patients with GERD had significantly larger num-

ber of psychiatric rehospitalizations (mean = 5.4 (SD 6.82)) than

MDD patients with no GERD (mean = 3.1 (SD 4.45)). After adjust-

ment for all covariates, GERD significantly moderated the efficacy

of treatment of MDD (

= 0.048;

= 0.05)

( Figure 1 ).

Conclusion

To treat MDD effectively we should treat GERD as

well.

Figure 1

Number of psychiatric rehospitalizations in patients

withMDD and GERD; error bars represent 95% confidence intervals

(

= 1008).

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2017.01.559

EV0230

Comorbidity of major depressive

disorder and personality disorder

increase the risk for suicide

A. Mihai

1 ,

∗

, M. Mihai

, M.S. Mocan

, C.I. Moga

, E.V. Nistor

A. Mihai

University of medicine and pharmacy “Iuliu Hatieganu”, Student,

Cluj-Napoca, Romania

University of medicine and pharmacy, Targu Mures, Student, Targu

Mures, Romania

University of medicine and pharmacy, Targu Mures, Psychiatry,

Targu Mures, Romania

∗

Corresponding author.

Introduction

Personality disorder (PD) with an associated diag-

nostic of major depressive disorder (MDD) is a common occurrence,

being considered a factor of treatment resistant depression. In this

study, we compare two groups of patients’ one group having Major

Depressive Episode (MDD) and the other with MDD and PD as

comorbidity.

Methods

This is an observational study of all patients admitted

with diagnosis of MDD during onemonth period in an acute psychi-

atric hospital. Data collection is made using patients files. During

one month period a total number of 105 MDD cases were recorded

(group A-75 cases with MDD and group B-30 patients with PD and

MDD). The diagnosis was recorded in files by a specialist psychia-

trist. Data is analyzed using SPSS v.20.

Results

A significant difference is found when comparing age

groups, mean age for group A being 60 years and for group B

35 years (

= 0.05). Regarding suicide attempts a higher prevalence

is found in Group B (Group A 6.7%, Group B 20%) although with

statistical relevance (

= 0.04). Study limitation: small sample size

of group B does not allow analysis on different type of personality