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25th European Congress of Psychiatry / European Psychiatry 41S (2017) S53–S68


Workshop: brain changes in early onset psychosis


Structural brain abnormalities in

early onset psychosis: results from the

norment eop cohort

V. Lonning

1 ,

, S. Nerland


, R.E. Smelror


, T.P. Gurholt



I. Agartz



University of Oslo, Norment part Uio, oslo, Norway


Norment and K.G. Jebsen centre for psychosis research- institute of

clinical medicine- university of Oslo, department of psychiatric

research- diakonhjemmet hospital, Oslo, Norway

Corresponding author.


Cortical brain abnormalities are frequently

observed in adults with psychotic disorders, but few studies

have investigated adolescents with early-onset psychosis (EOP).

A previous magnetic resonance imaging (MRI) study from the

NORMENT group in Norway, found widespread cortical thinning

and smaller subcortical volumes in adult patients with psy-

chotic disorders, particularly schizophrenia, compared to healthy



Participants from the ongoing NORMENT adolescent

EOP-study, 30 patients (age: 13.3–18.3 years, mean age: 16.5, 66%

female) and 45 healthy adolescents (age: 13.6–18.8 years, mean

age: 16.2, 58% female), underwent 3 T MRI on the same scan-

ner. Surface-based morphometric analyses were performed using

FreeSurfer version 5.3.0. Group differences in vertex-wise corti-

cal volume, thickness and surface area were investigated by fitting

general linear models at each vertex on the surface. Age, sex and

group were entered as covariates, and a non-parametric cluster-

wise correction method for multiple comparisons was applied and

cluster-forming and cluster-wise threshold set at 0.05.


Preliminary results show thinner cortex in the left medial

frontal lobe and smaller surface area in the left temporoparietal

junction in EOP patients compared to healthy controls after correc-

tion for multiple comparisons.


Surface-based analysis is sensitive to alterations in

cortical morphology in an adolescent EOP sample. The regions

exhibiting reduced cortical thickness and area in EOP overlap with

findings in an adult psychosis sample. Large-scale studies are warr-

anted to better identify the pattern of abnormalities and clarify

effects of age, diagnosis and medication.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.


Frontostriatal dysconnectivity in

adolescent onset schizophrenia and

its associations with cognition: An

MRI volumetric and diffusion tensor

imaging study

A. James

1 ,

, H.M. Fernandes


, P. Alves Da Mota


, M. Hough



Oxford University, Psychiatry, Oxford, United Kingdom


Aarhus University, Department of Clinical Medicine, Center for

Music In the Brain, Aarhus, Denmark


University of Oxford, FMRIB, Oxford, United Kingdom

Corresponding author.


Adolescent-onset schizophrenia (AOS) is associated

with cognitive impairment and poor clinical outcome. Cogni-

tive dysfunction is thought to reflect functional dysconnectivity

between the frontal cortex and the striatum, Previous work

[1] h


shown frontostriatal dysconnectivity in large WM tracts explain

core cognitive deficits, with processing speed, which is affected by

alterations in WM connectivity, being an intermediary variable.


To undertake a follow-upMRI study using whole-brain

structural connectomics to track topological changes in the follow-

up (1st episode versus follow-up), in order to characterize the early

stages (evolution of the first two years) of the disorder.


A follow-up study of 25 AOS subjects and 25 age and sex-

matched healthy subjects.


Network theory will be applied to identify topological

alterations in structural networks, including frontostriatal white

matter (WM) tracts in relation to cognition and outcome measures.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.


[1] James A, Joyce E, Lunn D, Hough M, Kenny L, Ghataorhe P,

et al. Abnormal frontostriatal connectivity in adolescent-onset

schizophrenia and its relationship to cognitive functioning. Eur

Psychiatry 2016;35:32–8.


Auditory cortex characteristics in

early onset psychosis and its

associations with auditory

hallucinations: A structural MRI Study

R.E. Smelror


, V. Lonning

1 ,

, L. Mørch-Johnsen


, S. Nerland



T. Gurholt


, I. Agartz



NORMENT and K.G. Jebsen Centre for Psychosis Research, Institute

of Clinical Medicine, University of Oslo, Department of Psychiatric

Research, Diakonhjemmet Hospital, Oslo, Norway


NORMENT and K.G. Jebsen Centre for Psychosis Research, Institute

of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo,


Corresponding author.


Smaller auditory cortex volume in schizophre-

nia patients with auditory hallucinations (AH) may be a result

of reduced cortical surface area and/or cortical thickness. A

neuro–imaging study from our group demonstrated that adult

schizophrenia spectrum patients with AH had significantly thinner

cortex in the left side Heschl’s gyrus (HG), compared to patients

without AH, and healthy controls (HC).


This study aims to investigate if adolescents with

early-onset psychosis (EOP) and AH demonstrate thinner cortices

in HG, as found in Mørch-Johnsen et al. in 2016, compared to EOP

patients without AH, and HC.


EOP patients (schizophrenia spectrum, psychotic disor-

der not otherwise specified) (


= 29) underwent MRI. Mean volume,

cortical thickness and surface area in auditory cortex regions (HG,

superior temporal gyrus [STG]) were compared between patients

with AH (


= 20) and without AH (


= 9), measured with item P3

from the Positive And Negative Syndrome Scale (PANSS), and 48



Preliminary results show no significant differences

between patients with and without AH and HC in mean volume,

cortical thickness, or surface area in HG or STG. There were no

significant side differences across hemispheres for these structures.


AH in EOP were not related to smaller volume, thin-

ner cortex or reduced surface area in auditory cortex regions. To

overcome the limitation of having a relatively small sample size,

the sample will be expanded with other EOP cohorts. Investiga-

tions into HG structure variation in relation to AH in EOP will also

be conducted.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.